Results 141 to 150 of about 591,105 (206)

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Studies of diaphragm fatigue and dysfunction [Elektronisk resurs]

, 2001
Diaphragm fatigue and dysfunction are important components of acute and chronic respiratory pump failure. We lack knowledge about the nature of diaphragm fatigue and the pathophysiological and morphological changes that occur in the diaphragm after ...
Radell, PJ,
core  

Deltex 2 Mediates Oxidative Stress and Neurotoxicity in Freezing of Gait of Parkinson's Disease via the Notch2‐Nrf2 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Under normal conditions, Notch2 promotes Nrf2 transcription by forming a transcriptional activation complex, which is crucial for maintaining the antioxidant capacity of human dopamine‐like neural cells. In pathological conditions, increased DTX2 expression has been shown to mediate Notch2 ubiquitination and subsequent degradation, leading to reduced ...
Qibin Zheng, Xiaohua Zheng, Junxin Zhao, Lin Lin, Yibiao Chen, Huiqing Wang, Zhangya Lin, Lianghong Yu   +7 more
wiley   +1 more source

The contribution of mechanical ventilation to critical illness-associated diaphragm dysfunction: longitudinal trajectories alone do not establish causal primacy. [PDF]

Crit Care
Feng X, Yang M, Xu W.
europepmc   +1 more source

Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients. [PDF]

Sci Rep, 2022
Zheng J, Yin Q, Wang SY, Wang YY, Xiao JJ, Tang TT, Ni WJ, Ren LQ, Liu H, Zhang XL, Liu BC, Wang B.   +11 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

The contribution of mechanical ventilation to critical illness-associated diaphragm dysfunction: a critical appraisal. [PDF]

Crit Care
Rosà T, Doorduin J, Grieco DL, Antonelli M, Ottenheijm CAC, Heunks L.   +5 more
europepmc   +1 more source

Comparison Between Respiratory‐Triggered and Free‐Breathing Signal Acquisition Methods for Single‐Voxel Phosphorus Magnetic Resonance Spectroscopy of the Liver on a Clinical System

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 702-711, September 2026.
ABSTRACT Background The optimal protocol for clinical liver 31P‐magnetic resonance spectroscopy (MRS) remains unclear. Single‐voxel 31P‐MRS using image‐selected in vivo spectroscopy (ISIS) employs respiratory‐triggering (RT) or free‐breathing (FB) acquisition.
Kumi Ozaki, Jihun Kwon, Marc Van Cauteren, Yasutomo Katsumata, Yukichi Tanahashi, Satoshi Goshima   +5 more
wiley   +1 more source

Construction and validation of a risk prediction model for early ventilator-induced diaphragm dysfunction in mechanically ventilated patients. [PDF]

Front Med (Lausanne)
Long MQ, Liu YT.
europepmc   +1 more source

Non‐Pharmacological Interventions for the Treatment of Lumbopelvic Pain in Pregnant Women: A Systematic Review Protocol Using the TIDieR Checklist

Musculoskeletal Care, Volume 24, Issue 3, September 2026.
ABSTRACT Background Lumbopelvic pain (LPP) is one of the most common complaints during pregnancy, with a reported prevalence of 63%. During pregnancy, treatment should preferably be non‐invasive. However, scientific evidence on non‐pharmacological interventions for pregnant women with LPP is still limited. Objective To synthesise the available evidence
Marília Caroline Ventura Macedo Leite, Mateus Dantas Azevedo de Lima, Rafaela Jéssica Silveira de Souza, Vanessa Patrícia Soares de Souza, Elizabel de Souza Ramalho Viana   +4 more
wiley   +1 more source