Pharmacology Research & Perspectives, 2021 Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically ...
Alexander Dashwood +8 more
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Diastolic heart failure: boundaries of term application
Бюллетень сибирской медицины, 2023 Important changes regarding the understanding of the pathogenesis of chronic heart failure (CHF) marked the beginning of the millennium, and its first decade was called the decade of diastology.
V. V. Kalyuzhin +11 more
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Structure-based finite strain modelling of the human left ventricle in diastole [PDF]
, 2013 Finite strain analyses of the left ventricle provide important information on heart function and have the potential to provide insights into the biomechanics of myocardial contractility in health and disease. Systolic dysfunction is the most common cause
Ogden, R.W. +13 more
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The Turkish Journal of Pediatrics, 2019 Regular blood transfusions for children with beta thalassemia major (β- TM) results in iron overload cardiomyopathy/cardiac failure. Mortality in these children is most often because of heart failure.
Chetan Kumar Nanjegowda +6 more
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CLINICAL ROLE OF CRITICAL CARE ECHOCARDIOGRAPHY IN SEPTIC PATIENTS: CURRENT KNOWLEDGE AND FUTURE DIRECTIONS [PDF]
Euromediterranean Biomedical Journal, 2020 Critical care echocardiography (CCE) use is rapidly growing and echocardiography is recommended as first-line approach to patients presenting with shock.
Cristina Santonocito
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The significant coronary tortuosity and atherosclerotic coronary artery disease; What is the relation? [PDF]
Journal of Cardiovascular and Thoracic Research, 2018 Introduction: Although coronary tortuosity is relatively common in coronary angiograms, there is much debate over the significance of this anatomical variation.
Mohsen Khosravani-Rudpishi +2 more
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Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness
Frontiers in Physiology, 2021 The heart is viscoelastic, meaning its compliance is inversely proportional to the speed at which it stretches. During diastolic filling, the left ventricle rapidly expands at rates where viscoelastic forces impact ventricular compliance.
Matthew A. Caporizzo +1 more
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Inorganic phosphate accelerates cardiac myofilament relaxation in response to lengthening
Frontiers in Physiology, 2022 Myocardial relaxation in late systole is enhanced by increasing velocities of lengthening. Given that inorganic phosphate (Pi) can rebind to the force-producing myosin enzyme prior to MgADP release and hasten crossbridge detachment, we hypothesized that ...
Jane I. Wakefield +2 more
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Patologìâ, 2014 Aims. Diastolic dysfunction of the left ventricle in patients with coronary artery disease affects the prognosis and is associated with the frequency of hospitalization for fi rst arisen heart failure. Methods and results.
V. D. Syvolap, Ya. V. Zemlyaniy
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Influence of manual thrombus aspiration on left ventricular diastolic function in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2016 Introduction. Data on effects of thrombus aspiration on left ventricular diastolic function in ST-elevation myocardial infarction (STEMI) population are scarce. Objective.
Ilić Ivan +13 more
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