Results 81 to 90 of about 5,364,392 (254)

Blood pressure trajectory during late pregnancy and the risk of severe preeclampsia-related complications: a retrospective cohort study

BMC Pregnancy and Childbirth
Background In non-pregnant populations, blood pressure variability is an independent predictor of adverse cardiovascular outcomes. However, its prognostic value for stratifying risk among women who have already developed hypertensive disorders of ...
Zeliang Yu, Yinan Wang, Xi Chen, Xiong Yu, Yawei Zhu, Xiaotian Li, Shuqin Zhang, Qiongjie Zhou   +7 more
doaj   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Kumari, Meena, Hoti, Mimoza, Samani, NJ, Peeter Juhanson, Elliott Paul, C. Ji (7611359), M. Marmot (7611368), Anna F Dominiczak, Juhanson, P, Marmot, Michael, Connell, JM, Philip Howard, Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), J. Chambers (3846385), Veldre, G, Farrall, Martin, Connell John M., Pasquale Strazzullo, John Chambers, Marmot Michael, Dobson, R, Kumari, M, Burke, Beverley, Samani Nilesh J., Brown, M. J. (Morris Jonathan), Morris Brown, Newhouse, Stephen; id_orcid, Elliott, Paul, Gudrun Veldre, Shaw-Hawkins, Sue, B. Burke (7611347), Strazzullo, P, Dobson, Richard; id_orcid, R. Collins (7159586), Iacone, Roberto, Cappuccio, Francesco P., Laan, Maris, Lathrop, G. Mark, Kooner, Jaspal, Munroe, Patricia B., Clarke, R, Beverley Burke, Brunner, Eric, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Lee, Kate, Hoti, M, Samani, Nilesh J., Francesco P Cappuccio, Newhouse Stephen, P. Howard (7611350), Richard Dobson, S. Newhouse (6642536), Juhanson Peeter, Elliott, P, Org, E, Nilesh J. Samani (7579793), Farrall, M, Burke Beverley, Lathrop G. Mark, Paul Elliott, Newhouse, S, Veldre, Gudrun, E. Org (7602644), Wallace Chris, Burke, B, Caulfield, Mark, Chambers, John, Marmot, Michael G., Martin Farrall, John M Connell, Onipinla Abiodun, Hoti Mimoza, M. Laan (7602659), Maris Laan, Dominiczak, AF, J. M. Connell (7602551), M. Viigimaa (7602620), Cappuccio Francesco P., Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Kate Lee, Shaw-Hawkins Sue, Susana Eyheramendy, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Brown, Morris, Jaspal Kooner, Wallace, C, M. Farrall (6522599), Dominiczak Anna F., S. Eyheramendy (7611197), Roberto Iacone, Caulfield, M, Eric Brunner, Lee, K, Chris Wallace, Strazzullo Pasquale, Brunner Eric, M. Brown (3020991), G. M. Lathrop (7611353), Collins Rory, G Mark Lathrop, Juhanson, Peeter, Ji Chen, Meena Kumari, Howard Philip, Cappuccio, Francesco, Chambers, John, MD, Org, Elin, Caulfield Mark, K. Lee (1769563), E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Iacone, R, Brunner, E, Margus Viigimaa, F. P. Cappuccio (7611356), Wallace, Chris, P. Elliott (1293702), Viigimaa, Margus, R. Dobson (6375266), A. F. Dominiczak (7602482), Chen Ji, Connell, John M., Connell, J. M. C., Sue Shaw-Hawkins, Dobson, Richard, Munroe Patricia B., Clarke, Robert, Eyheramendy, S, Rory Collins, Patricia B Munroe, Howard, P, M. Caulfield (7609097), Eyheramendy, Susana, Collins, Rory, Dobson Richard, Veldre Gudrun, Mimoza Hoti, Stephen Newhouse, Collins, R, M. Hoti (7611344), Laan Maris, Elin Org, Robert Clarke, Ji, C, Viigimaa, M, Shaw-Hawkins, S, Onipinla, Abiodun, Michael Marmot, Dominiczak, A. F., Mark Caulfield, R. Iacone (7611362), Abiodun Onipinla, G. Veldre (7602656), Clarke Robert, Eyheramendy Susana, A. Onipinla (7602377), M. Kumari (7602503), Kooner Jaspal, P. Juhanson (7602641), Nilesh J Samani, Dominiczak, Anna F., Lee Kate, Chambers, J, Strazzullo, Pasquale, Howard, Philip, Ji, Chen, Kooner, J, Brown Morris, J. Kooner (7609340), R. Clarke (7602407), Laan, M   +183 more
core   +2 more sources

Body Size Predicts Cardiac and Vascular Resistance Effects on Men's and Women's Blood Pressure

Frontiers in Physiology, 2017
Key Points SummaryWe report how blood pressure, cardiac output and vascular resistance are related to height, weight, body surface area (BSA), and body mass index (BMI) in healthy young adults at supine rest and standing.Much inter-subject variability in
Joyce M. Evans, Siqi Wang, Christopher Greb, Vladimir Kostas, Charles F. Knapp, Qingguang Zhang, Eric S. Roemmele, Michael B. Stenger, David C. Randall   +8 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration [PDF]

, 2009
Background and Purpose—High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses “baseline” BP was measured 24 hours or more postictus, and not during the hyperacute period.
Bath, P.M.B., M. Ali, Sare, Gillian M., Bath, Philip M.W., P. M.W. Bath, Sare, G.M., Ali, M., Shuaib, A., Ali, Myzoon, null null, Shuaib, Ashfaq, A. Shuaib, G. M. Sare   +12 more
core   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source

Rosiglitazone reduces office and diastolic ambulatory blood pressure following 1-year treatment in non-diabetic subjects with insulin resistance

, 2007
Objective. Rosiglitazone (RSG) has been reported to reduce blood pressure (BP) in patients with type-2 diabetes, but similar effects in non-diabetic people with insulin resistance is less clear.
Nilsson, Peter,, Hedblad, Bo,, Berglund, Göran,, Donaldson, Jill, Lund University.   +4 more
core   +1 more source