Results 11 to 20 of about 1,526,915 (347)

Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal, 2020
BackgroundImpaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM).
Hokyou Lee, Gyuri Kim, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh   +9 more
doaj   +2 more sources

Cardiac macrophages promote diastolic dysfunction

Journal of Experimental Medicine, 2018
Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a hallmark of cardiac aging and heart failure with preserved ejection fraction,
Ahmed Tawakol, Michael T. Osborne, Ronglih Liao, Gregory Wojtkiewicz, Benoit Tricot, Judy Hung, Claudio Vinegoni, Nicholas E. Houstis, Michael R. Zile, Maarten Hulsmans, Jason D. Roh, Flora Sam, Yuan Sun, David E. Sosnovik, Filip K. Swirski, Hendrik B. Sager, Ralph Weissleder, Anthony Rosenzweig, Kamila Naxerova, Richard M. Wilson, Amy D. Bradshaw, María Valero-Muñoz, Yoshiko Iwamoto, Matthias Nahrendorf   +23 more
core   +2 more sources

Mitochondrial oxidative stress contributes to diastolic dysfunction through impaired mitochondrial dynamics

Redox Biology, 2022
Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a clinical syndrome associated with aging that is becoming more prevalent. Despite extensive clinical studies, no effective treatment exists for HFpEF.
A. Lozhkin, Aleksandr E. Vendrov, R. On, Chandrika Canugovi, M. Stevenson, T. Herron, S. Hummel, Alberto Figueroa, D. Bowles, L. Isom, M. Runge, N. Madamanchi, Redox Biology   +12 more
semanticscholar   +1 more source

Sex differences in heart mitochondria regulate diastolic dysfunction

Nature Communications, 2022
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias.
Yang Cao, L. Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, T. Moore, M. Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, S. Charugundla, Christoph D. Rau, M. Seldin, Jessica J Wang, Yibin Wang, T. Vondriska, K. Reue, A. Lusis   +16 more
semanticscholar   +1 more source

Deep-Learning Models for the Echocardiographic Assessment of Diastolic Dysfunction.

JACC Cardiovascular Imaging, 2021
OBJECTIVES The authors explored a deep neural network (DeepNN) model that integrates multidimensional echocardiographic data to identify distinct patient subgroups with heart failure with preserved ejection fraction (HFpEF).
A. Pandey, N. Kagiyama, N. Yanamala, Matthew W. Segar, J. Cho, M. Tokodi, P. Sengupta   +6 more
semanticscholar   +1 more source

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function on Cardiovascular Death

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Coronary microvascular dysfunction (CMD) has been considered as a possible cause of cardiac diastolic dysfunction. The current study evaluated the association between cardiac diastolic dysfunction and CMD, and their prognostic implications in ...
David Hong, Seung Hun Lee, Doosup Shin, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Hyun Sung Joh, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo‐Yong Hahn, Seung‐Hyuk Choi, Hyeon‐Cheol Gwon, Joo Myung Lee   +13 more
doaj   +1 more source

Effect of Treadmill Test According to Bruce Protocol Stage 1 on Left Ventricular Diastolic Function in Patients with Exertional Dyspnea and Normal Left Ventricular Function [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Diastolic dysfunction, detected commonly by echocardiography is the fore-runner of Heart Failure (HF) with preserved Ejection Fraction (HFpEF) in future.
Jayanta Saha, Satyendra Nath Dutta, Kuntal Bhattacharyya   +2 more
doaj   +1 more source

FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity.

Cell Reports, 2021
Type 2 diabetes (T2D) increases the risk for diabetic cardiomyopathy and is characterized by diastolic dysfunction. Myocardial forkhead box O1 (FoxO1) activity is enhanced in T2D and upregulates pyruvate dehydrogenase (PDH) kinase 4 expression, which ...
K. Gopal, Rami Al Batran, T. Altamimi, A. Greenwell, C. Saed, S. A. Tabatabaei Dakhili, M. T. E. Dimaano, Yongneng Zhang, F. Eaton, G. Sutendra, J. Ussher   +10 more
semanticscholar   +1 more source

Maternal Cardiac Diastolic Dysfunction by Doppler Echocardiography in Women with Preeclampsia [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Preeclampsia may lead to heart failure in late pregnancy and early puerperium. Diastolic dysfunction may be the cause of heart failure in these patients.
Tanuja Muthyala, Saurabh Mehrotra, Pooja Sikka, Vanita Suri   +3 more
doaj   +1 more source

Elastic recoil signal on tissue doppler imaging of mitral annulus as a qualitative test to identify left ventricular diastolic function

Annals of Cardiac Anaesthesia, 2023
Introduction: Left ventricular (LV) diastolic dysfunction is common on preoperative screening among patients undergoing surgery. There is no simple screening test at present to suspect LV diastolic dysfunction. This study was aimed to test the hypothesis,
Deepak Prakash Borde, Devarakonda Bhargava Venkata, Shreedhar Joshi, Amish Jasapara, Pooja Joshi, Balaji Asegaonkar   +5 more
doaj   +1 more source