Results 171 to 180 of about 441,838 (286)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Comprehensive evaluation of diastolic function with MRI

Journal of Cardiovascular Magnetic Resonance, 2009
Esch Ben, Scott Jessica, Chow Kelvin, Baron June, Richard Thompson, Haykowsky Mark, Paterson Ian   +6 more
doaj   +1 more source

Reproducibility of diastolic function parameters in repeated ECG-gated SPECT myocardial perfusion imaging and echocardiography. [PDF]

Clin Physiol Funct Imaging
Krohns A, Laitinen TP, Laitinen TM, Sillanmäki S.   +3 more
europepmc   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Blood Flow Restriction Training Improves Cardiac Structure and Diastolic Function in Runners with Exercise-Induced Hypertension. [PDF]

J Clin Med
Kim YJ, Lee JY, Park CH, Park HS.
europepmc   +1 more source

Assessment of left-ventricular diastolic function in diabetic patients: the role of cardiac MR imaging

, 2013
İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, ENBİYA AKSAKAL, Hayri Oğul, Ahmet Arif Yalçın, Yeşim Kızrak, Mecit Kantarcı   +7 more
openalex   +2 more sources

1040 Adverse effects of the metabolic deregulation on aortic stiffness and diastolic function in patients with metabolic syndrome assessed with magnetic resonance imaging [PDF]

, 2008
Stijntje D. Roes, Reza Alizadeh Dehnavi, Jos J.M. Westenberg, Hildo J. Lamb, Jouke T. Tamsma, Albert de Roos   +5 more
openalex   +1 more source

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, EarlyView.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

Effects of 12 Weeks of Calanus Oil Supplementation on Cardiac Diastolic Function in Obese and Prediabetic Women-A Pilot Study. [PDF]

Metabolites
Kerlikowsky F, Spahiu F, Stöhr EJ, Junge S, Jonas W, Flierdt EV, Schuchardt JP, Hahn A.   +7 more
europepmc   +1 more source