Results 1 to 10 of about 144,206 (380)

Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively polisynaptic routes by stimulating inhibitory action of GABA.
Šegrt Zoran, Đorđević Snežana, Jaćević Vesna, Kilibarda Vesna, Vučinić Slavica, Jović-Stošić Jasmina, Potrebić Olivera, Vukčević-Perković Nataša   +7 more
doaj   +5 more sources

Diazepam causes sedative rather than anxiolytic effects in C57BL/6J mice

Scientific Reports, 2021
Diazepam has been broadly accepted as an anxiolytic drug and is often used as a positive control in behavioral experiments with mice. However, as opposed to this general assumption, the effect of diazepam on mouse behavior can be considered rather ...
Marina Pádua-Reis, Diana Aline Nôga, Adriano B. L. Tort, Martina Blunder   +3 more
doaj   +2 more sources

Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy

Epilepsia, 2021
A Phase 3 open‐label safety study (NCT02721069) evaluated long‐term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.
James Wheless, Ian Miller, Robert Hogan
exaly   +2 more sources

Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

Epilepsia, 2020
The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product ...
Robert Hogan, Barry E Gidal, Enrique Carrazana   +2 more
exaly   +2 more sources

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors

Molecular Psychiatry, 2017
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood ...
Michael A Van Der Kooij, Fiona Hollis, Ioannis Zalachoras   +2 more
exaly   +2 more sources

Diazepam and Fluoxetine Decrease the Stress Response in Zebrafish

PLoS ONE, 2014
The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized.
Murilo Sander de Abreu, Gessi Koakoski, Darlan Gusso   +2 more
exaly   +2 more sources

The Effects of Diazepam Administration on Hemodynamic Variables in Hypertensive Patients Who Undergoing Cataract Surgery

Archives of Anesthesia and Critical Care, 2019
Background: The purpose of this study was the evaluation of diazepam administration on perioperative blood pressure in hypertensive patients who undergoing cataract surgery.
Mehdi Sanatkar, Mehrdad Shorooghi, Ensiyeh Shakarami, Mehdi Mokhlesiyan   +3 more
doaj   +2 more sources

Classics in Chemical Neuroscience: Diazepam (Valium)

ACS Chemical Neuroscience, 2014
James C Barrow
exaly   +2 more sources

Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles

AAPS PharmSciTech, 2015
Rakesh Kumar Sharma, Javed Ali, Shweta Dang   +2 more
exaly   +2 more sources

Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety

Pharmacology Biochemistry and Behavior, 2009
Edward D Levin
exaly   +2 more sources