Results 271 to 280 of about 83,280 (287)

Efficacy of Sublingual Lorazepam Versus Intrarectal Diazepam for Prolonged Convulsions in Sub-Saharan Africa

Journal of Child Neurology, 2014
In Sub-Saharan Africa, intrarectal diazepam is the first-line anticonvulsant mostly used in children. We aimed to assess this standard care against sublingual lorazepam, a medication potentially as effective and safe, but easier to administer.
C. Malu, Daniel Mukeba Kahamba, T. Walker, C. Mukampunga, E. M. Musalu, J. Kokolomani, Richard Mukendi Kavulu Mayamba, J. Wilmshurst, J. Dubru, J. Misson   +9 more
semanticscholar   +1 more source

The role of diazepam loading for the treatment of alcohol withdrawal syndrome in hospitalized patients.

American Journal on Addictions, 2013
BACKGROUND Alcohol withdrawal accounts for a significant amount of hospital admissions and can quickly progress to the development of delirium tremens (DTs), seizures, and death. Rapid identification and management of alcohol withdrawal syndrome (AWS) is
A. Muzyk, J. Leung, S. Nelson, Eric R Embury, Sharon Jones   +4 more
semanticscholar   +1 more source

Effects of diazepam on BOLD activation during the processing of aversive faces

Journal of Psychopharmacology, 2012
This study aimed to measure, using fMRI, the effect of diazepam on the haemodynamic response to emotional faces. Twelve healthy male volunteers (mean age = 24.83 ± 3.16 years), were evaluated in a randomized, balanced-order, double-blind, placebo ...
C. Del-Ben, C. Ferreira, T. A. Sanchez, W. C. Alves-Neto, V. G. Guapo, D. D. de Araujo, F. Graeff   +6 more
semanticscholar   +1 more source

Vaginal diazepam use with urogenital pain/pelvic floor dysfunction: serum diazepam levels and efficacy data.

Urologic Nursing, 2011
Vaginal diazepam is used off-label for pelvic floor dysfunction and urogenital pain, but serum levels with efficacy have not been reported until now. One clinician evaluated 21 women for overall, levator, and vulvar pain pre- and one-month post-daily ...
D. Carrico, K. Peters
semanticscholar   +1 more source

β-Cyclodextrin conjugated magnetic nanoparticles for diazepam removal from blood.

Chemical Communications, 2011
β-CD conjugated magnetic nanoparticles that serve as a hemoadsorbent for diazepam removal are fabricated. The diazepam is arrested by the conjugated β-CD and then the adsorbed diazepam is efficiently removed by an external magnetic field. These particles
K. Cai, Jinghua Li, Zhong Luo, Yan Hu, Yanhua Hou, Xingwei Ding   +5 more
semanticscholar   +1 more source

Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs.

Journal of Veterinary Pharmacology and Therapeutics, 2011
The standard of care for emergency therapy of seizures in veterinary patients is intravenous (i.v.) administration of benzodiazepines, although rectal administration of diazepam is often recommended for out-of-hospital situations, or when i.v. access has
Sarah E Musulin, Christopher L. Mariani, M. Papich   +2 more
semanticscholar   +1 more source

A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations

Epilepsia, 2010
Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted.
G. de Haan, P. J. van der Geest, G. Doelman, E. Bertram, P. Edelbroek   +4 more
semanticscholar   +1 more source

Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs

Drug and chemical toxicology (New York, N.Y. 1978), 2010
Near-lethal exposure to nerve agents produces prolonged epileptiform seizures requiring the administration of benzodiazepine anticonvulsant drugs, such as diazepam. Clinically, benzodiazepines are reported to lose anticonvulsant effectiveness the greater
J. McDonough, J. McMonagle, T. Shih
semanticscholar   +1 more source

Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish Danio rerio.

Environmental Science and Technology, 2010
We applied zebrafish whole genome microarrays to identify molecular effects of diazepam, a neuropharmaceutical encountered in wastewater-contaminated environments, and to elucidate its neurotoxic mode of action.
D. Oggier, Christin J Weisbrod, A. Stoller, Armin K. Zenker, K. Fent   +4 more
semanticscholar   +1 more source

Diazepam in the Treatment of Moderate to Severe Alcohol Withdrawal

CNS Drugs, 2017
S. Weintraub
semanticscholar   +1 more source