Results 231 to 240 of about 13,368 (258)
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On the Mechanism of Diazoxide-induced Hyperglycemia
Diabetes, 1977Infusion of diazoxide (16.5 mg./kg. in 10 minutes) into normal unanesthetized dogs resulted in a prompt hyperglycemia due to increased hepatic glucose production as measured with a 3-3H-glucose primer-infusion technique. Plasma insulin and gtucagon were decreased. Glucose uptake failed to increase.
Jennifer Hampshire +2 more
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Toxicology and Applied Pharmacology, 1975
Abstract Diazoxide, a vasodilating antihypertensive drug, caused tachycardia when given to dogs as iv doses of 10–40 mg/kg. Doses of 20–40 mg/kg, given on 2 or 3 consecutive days, caused myocardial necroses similar to that produced by hydralazine. The papillary muscles were the primary sites of the lesion.
F.W. Wolff +3 more
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Abstract Diazoxide, a vasodilating antihypertensive drug, caused tachycardia when given to dogs as iv doses of 10–40 mg/kg. Doses of 20–40 mg/kg, given on 2 or 3 consecutive days, caused myocardial necroses similar to that produced by hydralazine. The papillary muscles were the primary sites of the lesion.
F.W. Wolff +3 more
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Diazoxide in the Treatment of Infantile Hypoglycemia
New England Journal of Medicine, 1966IN the majority of infants with chronic hypoglycemia the specific origin of the disorder cannot be identified. Regardless of etiology, correction of the hypoglycemia is essential to prevent mental retardation. Except in the rare case of islet-cell adenoma pancreatic surgery in infants with hypoglycemic states has given disappointing results.
Tullio R. Mereu +2 more
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Journal of Pharmaceutical Sciences, 1967
Blood diazoxide levels were measured in six adult human males at various times after i.v. drug administration. On the basis of these results, the diazoxide half-life in blood was determined as 28.0 ± 8.3 hr. The presence of diazoxide in blood was verified by thin-layer chromatography (TLC) and by its U.V. spectrum. This communication describes a simple
L. Winston +5 more
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Blood diazoxide levels were measured in six adult human males at various times after i.v. drug administration. On the basis of these results, the diazoxide half-life in blood was determined as 28.0 ± 8.3 hr. The presence of diazoxide in blood was verified by thin-layer chromatography (TLC) and by its U.V. spectrum. This communication describes a simple
L. Winston +5 more
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Diazoxide in Primary Pulmonary Hypertension
New England Journal of Medicine, 1980PRIMARY pulmonary hypertension is a disease of unknown cause, predominantly occurring in young women and resulting in right ventricular failure and death in an average of seven years.1 Spontaneous ...
Klinke Wp, Gilbert Ja
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A case of severe diazoxide toxicity
Pediatric Anesthesia, 2004SummaryHyperinsulism is a rare cause of persistent hypoglycemia in the neonatal period. Therapy can be accomplished either surgically or pharmacologically. Diazoxide treatment remains the mainstay of medical therapy. Tolerance of diazoxide is usually excellent, but several adverse effects of this drug have been described.
Andrea Wolfler +4 more
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Treatment of Chlorpropamide Overdose with Diazoxide
Drug Intelligence & Clinical Pharmacy, 1983A patient who took a chlorpropamide overdose was treated for several hours with concentrated glucose solutions, with little success in maintaining adequate serum glucose concentrations. Intravenous diazoxide administration was begun with the hope of decreasing pancreatic insulin release.
William H. Jeffery, E. Michael Graham
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Mechanisms of action of diazoxide.
The Journal of laboratory and clinical medicine, 1967Abstract The mechanism of action of diazoxide vas investigated in dogs. Immunoreactive insulin, glucose, and free fatty acids were determined in treated and control dogs following intravenously administered glucose. The slower disappearance of glucose in the treated animals was associated with almost complete IRI suppression. Alpha adrenergic receptor
Charles N. Aprill, William G. Blackard
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JAMA: The Journal of the American Medical Association, 1973
W A, Tansey +3 more
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W A, Tansey +3 more
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CLINICAL EXPERIENCE WITH DIAZOXIDE*
Annals of the New York Academy of Sciences, 1968John H. Karam +3 more
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