Results 81 to 90 of about 312 (115)

Synthesis and Evaluation of Dibenzothiazepines: A Novel Class of Selective Cannabinoid-1 Receptor Inverse Agonists

Journal of Medicinal Chemistry, 2009
A novel class of CB1 inverse agonists was discovered. To efficiently establish structure-activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed. The compounds were evaluated in a mammalian cell-based functional assay and in radioligand binding assays expressing recombinant human cannabinoid receptors ...
Fredrik Ek, Jian-Nong Ma, Andria L Del Tredici   +2 more
exaly   +3 more sources

STUDIES IN THE HETEROCYCLIC SERIES. XIV. THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF NEW AZA- AND THIA-PHENOTHIAZINES, AND RELATED DIBENZOTHIAZEPINES

Phosphorous and Sulfur and the Related Elements, 1978
Abstract Owing to increasing demand for phenothiazine compounds both in medicine and industry, novel rings in these series have been prepared and evaluated. The benzene rings have been replaced with pyrrole, pyrazole, pyridine, pyridazine, pyrimidine, pyrazine, thiazine and triazine rings or their combinations leading to twelve new polyaza- and thia ...
Charles O Okafor
exaly   +2 more sources

The pharmacological properties of a potent neurotropic compound from the dibenzothiazepine group

International Journal of Neuropharmacology, 1965
Abstract The new compound HF-2159 (2-chloro-ll-(4'-methyl)piperazino-dibenzo-[b,f] [1,4]-thiazepine) studied in this paper in comparison with chlorpromazine shows the following properties: 1. Inhibition of motor drive, as manifested in the locomotor activity of mice and in the ‘open field’ test with rats. Its effectiveness here is respectively six
G, Stille, H, Ackermann, E, Eichenberger, H, Lauener   +3 more
openaire   +2 more sources

ChemInform Abstract: Synthesis and Antibacterial Activities of New Dibenzothiazepine Derivatives.

ChemInform, 2011
AbstractThe newly synthesized dibenzothiazepines (III) are evaluated for their activity against both Gram‐positive and Gram‐negative bacteria.
Ganesh D. Mahale, Yogesh M. Kolekar, Ashok Kumar, Dharmendra Singh, Kisan M. Kodam, Suresh B. Waghmode   +5 more
openaire   +1 more source

ChemInform Abstract: Dibenzothiazepine a Break Through Heterocyclic Nucleus in Medicinal Chemistry

ChemInform, 2015
AbstractReview: 23 refs.
openaire   +1 more source

“One-Pot” CuCl2-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine

Molecules, 2022
Bingchuan Yang, Guodong Shen
exaly  

Synthesis of Dibenzothiazepine Dioxides by Reductive Heck Cyclization

Synfacts, 2015
openaire   +1 more source

ICI 204,636 (SEROQUEL™): A Dibenzothiazepine Atypical Antipsychotic. Review of Preclinical Pharmacology and Highlights of Phase II Clinical Trials

CNS Drug Reviews, 1995
Jeffrey M. Goldstein, Lisa A. Arvanitis
openaire   +1 more source

Pharmacology of ‘Seroquel’ (ICI 204,636): An atypical dibenzothiazepine antipsychotic

European Neuropsychopharmacology, 1996
openaire   +1 more source

COMPARATIVE ACTIVITIES OF A SUBSTITUTED DIBENZOTHIAZEPINE, OF IMIPRAMINE AND OF DESIPRAMINE.

Archives internationales de pharmacodynamie et de therapie, 1996
Z P, HOROVITZ, A R, FURGIUELE, J P, HIGH, J C, BURKE   +3 more
openaire   +1 more source