Results 121 to 130 of about 134,287 (354)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

L’autoritarisme du verdissement hydroélectrique au Panama : les paradoxes dérégulateurs de l’action climatique vus depuis le Sud

open access: yesLien Social et Politiques, 2019
Cet article interroge les effets dérégulateurs du Mécanisme de développement propre (MDP). Créé en 2001 par les Nations Unies, ce mécanisme incite les pays industrialisés soumis à des objectifs de réduction d’émissions de gaz à effet de serre dans le ...
Marie-Esther Lacuisse
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Formation of the 7-triphenylphosphonio-norbornen-7-ylium dication: a non-classical dication [PDF]

open access: green, 1973
Pieter E. Schipper   +3 more
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Fiscal effects of cannabis legalisation

open access: yesWirtschaftsdienst, 2021
Justus Haucap, Leon Knoke
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Long-lived [1.1.1.1]- and [2.2.1.1]-‘Isopagodane’ dications: novel 4C/2e σ-bishomoaromatic dications† [PDF]

open access: green, 1999
G. K. Surya Prakash   +8 more
openalex   +2 more sources

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