Results 1 to 10 of about 34,642 (262)
A Glimpse of “Dicer Biology” Through the Structural and Functional Perspective
Frontiers in Molecular Biosciences, 2021 The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene regulation.
Mandar V Deshmukh
exaly +3 more sources
Lineage-specific expansions of the Dicer gene family in tardigrades [PDF]
BMC GenomicsBackground RNA interference (RNAi) is an important pathway for gene regulation and immunity. Dicer is a conserved RNAi pathway protein that is found in eukaryotes, with many species expressing multiple dicer gene copies.
Bethany Weinberg +3 more
doaj +2 more sources
Cell ReportsSummary: The activation of the DNA-damage response (DDR) enforces the transcriptional silencing of genes near DNA double-strand breaks (DSBs), a process called DSB-induced silencing in cis (DISC).
Francesca Esposito +12 more
doaj +2 more sources
DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. [PDF]
PLoS ONE, 2015 Mechanistic studies of RNA processing in the RNA-Induced Silencing Complex (RISC) have been hindered by lack of methods for continuous monitoring of enzymatic activity. "Quencherless" fluorogenic substrates of RNAi enzymes enable continuous monitoring of
Mark A Bernard +2 more
doaj +1 more source
Frontiers in Microbiology, 2022 RNA interference (RNAi) is divided into canonical, Dicer-dependent and non-canonical, Dicer-independent pathways according to Dicer protein dependency.
Hyunjun Lee +9 more
doaj +1 more source
Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage. [PDF]
PLoS Genetics, 2018 Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of micro (mi)RNA in the cytoplasm. Increasing evidence suggests that mammalian Dicer is also present and active in the nucleus.
Kaspar Burger, Monika Gullerova
doaj +1 more source
Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway
Clinical Medicine Insights: Oncology, 2023 Background: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression.
Xin Han +7 more
doaj +1 more source
Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
PLoS ONE, 2015 Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection.
Jhih-Si Chen +6 more
doaj +1 more source
Prognostic significance of deregulated dicer expression in breast cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers.
Emer Caffrey +9 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
doaj +1 more source