Results 1 to 10 of about 41,308 (256)
DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. [PDF]
PLoS ONE, 2015 Mechanistic studies of RNA processing in the RNA-Induced Silencing Complex (RISC) have been hindered by lack of methods for continuous monitoring of enzymatic activity. "Quencherless" fluorogenic substrates of RNAi enzymes enable continuous monitoring of
Mark A Bernard +2 more
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Frontiers in Microbiology, 2022 RNA interference (RNAi) is divided into canonical, Dicer-dependent and non-canonical, Dicer-independent pathways according to Dicer protein dependency.
Hyunjun Lee +9 more
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Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage. [PDF]
PLoS Genetics, 2018 Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of micro (mi)RNA in the cytoplasm. Increasing evidence suggests that mammalian Dicer is also present and active in the nucleus.
Kaspar Burger, Monika Gullerova
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A Glimpse of “Dicer Biology” Through the Structural and Functional Perspective
Frontiers in Molecular Biosciences, 2021 The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene regulation.
Sneha Paturi, Mandar V. Deshmukh
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Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway
Clinical Medicine Insights: Oncology, 2023 Background: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression.
Xin Han +7 more
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Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
PLoS ONE, 2015 Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection.
Jhih-Si Chen +6 more
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Prognostic significance of deregulated dicer expression in breast cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers.
Emer Caffrey +9 more
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Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
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Dicer-dependent biogenesis of small RNAs derived from 7SL RNA. [PDF]
PLoS ONE, 2012 It has been reported that decreased Dicer expression leads to Alu RNAs accumulation in human retinal pigmented epithelium cells, and Dicer may process the endogenous SINE/B1 RNAs (the rodent equivalent of the primate Alu RNAs) into small interfering RNAs
Yong-Feng Ren +7 more
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Up-regulated Dicer expression in patients with cutaneous melanoma. [PDF]
PLoS ONE, 2011 BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression.
Zhihai Ma +5 more
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