Results 1 to 10 of about 34,675 (262)
Lineage-specific expansions of the Dicer gene family in tardigrades [PDF]
BMC GenomicsBackground RNA interference (RNAi) is an important pathway for gene regulation and immunity. Dicer is a conserved RNAi pathway protein that is found in eukaryotes, with many species expressing multiple dicer gene copies.
Bethany Weinberg +3 more
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Cell ReportsSummary: The activation of the DNA-damage response (DDR) enforces the transcriptional silencing of genes near DNA double-strand breaks (DSBs), a process called DSB-induced silencing in cis (DISC).
Francesca Esposito +12 more
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DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. [PDF]
PLoS ONE, 2015 Mechanistic studies of RNA processing in the RNA-Induced Silencing Complex (RISC) have been hindered by lack of methods for continuous monitoring of enzymatic activity. "Quencherless" fluorogenic substrates of RNAi enzymes enable continuous monitoring of
Mark A Bernard +2 more
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Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage. [PDF]
PLoS Genetics, 2018 Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of micro (mi)RNA in the cytoplasm. Increasing evidence suggests that mammalian Dicer is also present and active in the nucleus.
Kaspar Burger, Monika Gullerova
doaj +1 more source
Frontiers in Microbiology, 2022 RNA interference (RNAi) is divided into canonical, Dicer-dependent and non-canonical, Dicer-independent pathways according to Dicer protein dependency.
Hyunjun Lee +9 more
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A Glimpse of “Dicer Biology” Through the Structural and Functional Perspective
Frontiers in Molecular Biosciences, 2021 The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene regulation.
Sneha Paturi, Mandar V. Deshmukh
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Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway
Clinical Medicine Insights: Oncology, 2023 Background: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression.
Xin Han +7 more
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Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies [PDF]
International Journal of Molecular Sciences, 2020 Gene expression dictates fundamental cellular processes and its de-regulation leads to pathological conditions. A key contributor to the fine-tuning of gene expression is Dicer, an RNA-binding protein (RBPs) that forms complexes and affects transcription by acting at the post-transcriptional level via the targeting of mRNAs by Dicer-produced small non ...
Eleni I. Theotoki +6 more
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The paradox of dicer in cancer [PDF]
Molecular & Cellular Oncology, 2016 Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage ...
Swahari, Vijay +2 more
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Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
PLoS ONE, 2015 Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection.
Jhih-Si Chen +6 more
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