Results 21 to 30 of about 34,675 (262)
Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
Frontiers in Molecular Biosciences, 2022 In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang +6 more
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Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. [PDF]
PLoS ONE, 2013 Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA ...
Yuanqing Yan +9 more
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Journal of International Medical Research, 2021 Objective This study explored the functional interactions between the long non-coding RNA DICER-AS1 and the cellular stress response 1 ( CSR1 ) gene in gastric cancer.
Junyan An, Xiaoling Guo, Bingli Yan
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MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells
Cells, 2023 MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways ...
Kimberley M. Reid +7 more
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Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein.
PLoS Genetics, 2016 Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishment ...
Christian Much +7 more
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BioTechniques, 2010 The cleavage of double-stranded RNA (dsRNA) molecules by Dicer is a critical step in silencing genes by the RNA induced silencing complex (RISC). The development of Dicer substrates as nucleic acid–based therapeutics brings about a need to rapidly ...
Jonathan P. DiNitto +2 more
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The molecular architecture of human Dicer [PDF]
Nature Structural & Molecular Biology, 2012 Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes. Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas that of the large and complex Dicer in metazoans is unknown. Here we describe a new domain localization strategy developed to determine the structure of human Dicer by EM.
Lau, Pick-Wei +5 more
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The role of Dicer protein partners in the processing of microRNA precursors.
PLoS ONE, 2011 One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska +2 more
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Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects
Molecular Metabolism, 2019 Objective: Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER ...
Beatriz A. Guerra +13 more
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Journal of Experimental & Clinical Cancer Research, 2019 Background CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the progression of intrahepatic ...
Yongqiang Qi +7 more
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