Results 21 to 30 of about 41,308 (256)
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. [PDF]
PLoS ONE, 2010 To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all ...
Therese Andersson +8 more
doaj +1 more source
eLife, 2021 Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic
Raushan K Singh +5 more
doaj +1 more source
Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
Frontiers in Molecular Biosciences, 2022 In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang +6 more
doaj +1 more source
The Cytoplasmic MicroRNA-Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis. [PDF]
Adv Sci (Weinh)The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Zeng Y +6 more
europepmc +2 more sources
Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. [PDF]
PLoS ONE, 2014 The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail.
Yue J Wang +6 more
doaj +1 more source
Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. [PDF]
PLoS ONE, 2013 Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA ...
Yuanqing Yan +9 more
doaj +1 more source
MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells
Cells, 2023 MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways ...
Kimberley M. Reid +7 more
doaj +1 more source
Journal of International Medical Research, 2021 Objective This study explored the functional interactions between the long non-coding RNA DICER-AS1 and the cellular stress response 1 ( CSR1 ) gene in gastric cancer.
Junyan An, Xiaoling Guo, Bingli Yan
doaj +1 more source
Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein.
PLoS Genetics, 2016 Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishment ...
Christian Much +7 more
doaj +1 more source
BioTechniques, 2010 The cleavage of double-stranded RNA (dsRNA) molecules by Dicer is a critical step in silencing genes by the RNA induced silencing complex (RISC). The development of Dicer substrates as nucleic acid–based therapeutics brings about a need to rapidly ...
Jonathan P. DiNitto +2 more
doaj +1 more source