Results 21 to 30 of about 34,642 (262)

Rescuing dicer Defects via Inhibition of an Anti-Dicing Nuclease

Cell Reports, 2014
Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity.
Ken Asada, Emanuele Canestrari, Xiuping Fu, Zhi Li, Edward Makowski, Yen-Ching Wu, Jeffrey K. Mito, David G. Kirsch, Jay Baraban, Zain Paroo   +9 more
doaj   +1 more source

Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. [PDF]

PLoS ONE, 2014
The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail.
Yue J Wang, Florencia McAllister, Jennifer M Bailey, Sherri-Gae Scott, Audrey M Hendley, Steven D Leach, Bidyut Ghosh   +6 more
doaj   +1 more source

The molecular architecture of human Dicer [PDF]

Nature Structural & Molecular Biology, 2012
Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes. Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas that of the large and complex Dicer in metazoans is unknown. Here we describe a new domain localization strategy developed to determine the structure of human Dicer by EM.
Lau, Pick-Wei, Guiley, Keelan Z., De, Nabanita, Potter, Clinton S., Carragher, Bridget, MacRae, Ian J.   +5 more
openaire   +2 more sources

Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein.

PLoS Genetics, 2016
Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishment ...
Christian Much, Tania Auchynnikava, Dinko Pavlinic, Andreas Buness, Juri Rappsilber, Vladimir Benes, Robin Allshire, Dónal O'Carroll   +7 more
doaj   +1 more source

Continuous fluorescence-based method for assessing Dicer cleavage efficiency reveals 3′ overhang nucleotide preference

BioTechniques, 2010
The cleavage of double-stranded RNA (dsRNA) molecules by Dicer is a critical step in silencing genes by the RNA induced silencing complex (RISC). The development of Dicer substrates as nucleic acid–based therapeutics brings about a need to rapidly ...
Jonathan P. DiNitto, Leyu Wang, Joe C. Wu   +2 more
doaj   +1 more source

The role of Dicer protein partners in the processing of microRNA precursors.

PLoS ONE, 2011
One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska, Julia Starega-Roslan, Wlodzimierz J Krzyzosiak   +2 more
doaj   +1 more source

Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

Molecular Metabolism, 2019
Objective: Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER ...
Beatriz A. Guerra, Bruna B. Brandão, Silas S. Pinto, Willian G. Salgueiro, Evandro A. De-Souza, Felipe C.G. Reis, Thiago M. Batista, Vanessa Cavalcante-Silva, Vânia D'Almeida, Beatriz A. Castilho, Everardo M. Carneiro, Adam Antebi, William T. Festuccia, Marcelo A. Mori   +13 more
doaj   +1 more source

Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs

Frontiers in Cell and Developmental Biology, 2022
Tendon is a fibrous connective tissue, that is, transmitting the forces that permit body movement. However, tendon/ligament biology is still not fully understood and especially, the role of miRNAs in tendon/ligament is sparse and uncharacterized in in ...
Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Tomoyuki Nakasa, Masakazu Ishikawa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Shigeru Miyaki, Nobuo Adachi   +19 more
doaj   +1 more source

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the progression of intrahepatic ...
Yongqiang Qi, Da Wang, Wenhua Huang, Bing Wang, Di Huang, Fei Xiong, Xiaoping Chen, Yongjun Chen   +7 more
doaj   +1 more source

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]

Open Biology, 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson, Andrew M. Lew, Mark M. W. Chong   +2 more
doaj   +1 more source