Results 11 to 20 of about 34,642 (262)
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies [PDF]
International Journal of Molecular Sciences, 2020 Gene expression dictates fundamental cellular processes and its de-regulation leads to pathological conditions. A key contributor to the fine-tuning of gene expression is Dicer, an RNA-binding protein (RBPs) that forms complexes and affects transcription by acting at the post-transcriptional level via the targeting of mRNAs by Dicer-produced small non ...
Eleni I. Theotoki +6 more
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The paradox of dicer in cancer [PDF]
Molecular & Cellular Oncology, 2016 Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage ...
Swahari, Vijay +2 more
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Journal of the American Society of Nephrology, 2008 We should occasionally stop, take a breath, and reflect about what is happening at the interface between medicine and science. Collectively, we are uncovering paradigms that are relevant to understanding disease at a frantic pace.
J J David, Ho, Philip A, Marsden
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Dicer-dependent biogenesis of small RNAs derived from 7SL RNA. [PDF]
PLoS ONE, 2012 It has been reported that decreased Dicer expression leads to Alu RNAs accumulation in human retinal pigmented epithelium cells, and Dicer may process the endogenous SINE/B1 RNAs (the rodent equivalent of the primate Alu RNAs) into small interfering RNAs
Yong-Feng Ren +7 more
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eLife, 2021 Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic
Raushan K Singh +5 more
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Up-regulated Dicer expression in patients with cutaneous melanoma. [PDF]
PLoS ONE, 2011 BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression.
Zhihai Ma +5 more
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Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
Frontiers in Molecular Biosciences, 2022 In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang +6 more
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The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat
Epigenetics, 2017 microRNAs (miRs) are small noncoding RNAs that regulate/fine tune many cellular protein networks by targeting mRNAs for either degradation or translational inhibition.
Nicholas C. Hoffend +2 more
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Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. [PDF]
PLoS ONE, 2010 To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all ...
Therese Andersson +8 more
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MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells
Cells, 2023 MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways ...
Kimberley M. Reid +7 more
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