Rescuing dicer Defects via Inhibition of an Anti-Dicing Nuclease
Cell Reports, 2014 Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity.
Ken Asada +9 more
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HIV-1 Tat interaction with Dicer: requirement for RNA [PDF]
Retrovirology, 2006 Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here,
Jeang Kuan-Teh, Bennasser Yamina
doaj +2 more sources
TWEAK Negatively Regulates Human Dicer
Non-Coding RNA, 2016 The ribonuclease Dicer plays a central role in the microRNA pathway by processing microRNA precursors (pre-microRNAs) into microRNAs, a class of 19- to 24-nucleotide non-coding RNAs that regulate expression of ≈60% of the genes in humans. To gain further
Marine Lambert +6 more
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Small RNA pathways in mammalian oocytes. [PDF]
FEBS Open BioThree distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Svoboda P, Pasulka J.
europepmc +2 more sources
RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops. [PDF]
Adv Sci (Weinh)This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Zhang X +13 more
europepmc +2 more sources
Fission yeast Dicer harbours a unique dsRBD that participates in the spatial organization of the RNAi pathway [PDF]
, 2011 The term RNAi describes a set of conserved pathways found in most eukaryotes. RNAi is involved in various cellular processes, ranging from the control of gene expression to the establishment of heterochromatic structures.
Emmerth, Stephan
core +1 more source
Dicer-processed small RNAs: Rules and exceptions
, 2022 S.35-46Canonical microRNAs are excised from their hairpin-shaped precursors by Dicer. In order to find possible exceptions to this rule and to identify additional substrates for Dicer processing we re-evaluate the small RNA sequencing data of the Dicer ...
Cakir, M. Volkan +3 more
core +1 more source
Effective Silencing of Dicer Decreases Spore Load of the Honey Bee Parasite Nosema ceranae [PDF]
, 2016 Nosema ceranae is an intracellular parasite that infects honey bee mid-gut epithelial cells. Previously, we identified microRNA-like small RNAs and found evidence for expression of the N. ceranae gene coding Dicer. The Dicer protein is critical for small
Neumann, Peter +4 more
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MicroRNAs regulate "de novo" DNA methylation and histone mRNA 3' end formation in mammalian cells [PDF]
, 2008 MicroRNAs (miRNAs) are known to have many important functions in mammalian cells. They can influence the expression of their target genes and in this way regulate the function of not only their primary targets, but also of the pathways and mechanisms ...
Sinkkonen, Lasse
core +1 more source
The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat
Epigenetics, 2017 microRNAs (miRs) are small noncoding RNAs that regulate/fine tune many cellular protein networks by targeting mRNAs for either degradation or translational inhibition.
Nicholas C. Hoffend +2 more
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