Results 11 to 20 of about 34,675 (262)
Prognostic significance of deregulated dicer expression in breast cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers.
Emer Caffrey +9 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
doaj +1 more source
Dicer-dependent biogenesis of small RNAs derived from 7SL RNA. [PDF]
PLoS ONE, 2012 It has been reported that decreased Dicer expression leads to Alu RNAs accumulation in human retinal pigmented epithelium cells, and Dicer may process the endogenous SINE/B1 RNAs (the rodent equivalent of the primate Alu RNAs) into small interfering RNAs
Yong-Feng Ren +7 more
doaj +1 more source
Journal of the American Society of Nephrology, 2008 We should occasionally stop, take a breath, and reflect about what is happening at the interface between medicine and science. Collectively, we are uncovering paradigms that are relevant to understanding disease at a frantic pace.
J J David, Ho, Philip A, Marsden
openaire +2 more sources
Up-regulated Dicer expression in patients with cutaneous melanoma. [PDF]
PLoS ONE, 2011 BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression.
Zhihai Ma +5 more
doaj +1 more source
The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat
Epigenetics, 2017 microRNAs (miRs) are small noncoding RNAs that regulate/fine tune many cellular protein networks by targeting mRNAs for either degradation or translational inhibition.
Nicholas C. Hoffend +2 more
doaj +1 more source
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. [PDF]
PLoS ONE, 2010 To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all ...
Therese Andersson +8 more
doaj +1 more source
eLife, 2021 Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic
Raushan K Singh +5 more
doaj +1 more source
Rescuing dicer Defects via Inhibition of an Anti-Dicing Nuclease
Cell Reports, 2014 Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to loss of miRNA-generating activity.
Ken Asada +9 more
doaj +1 more source
Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. [PDF]
PLoS ONE, 2014 The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail.
Yue J Wang +6 more
doaj +1 more source