Results 41 to 50 of about 41,308 (256)
Kras-driven pancreatic lesions are sensitive to Dicer gene dosage.
, 2014 (A–D) Brown staining indicates immunohistochemical labeling for Dicer (hemotoxylin counterstain, blue). (A) Wildtype pancreas. There is strong cytoplasmic labeling for Dicer in acinar cells. (B) Dicer-wt-Kras.
Jennifer M. Bailey (470774) +6 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Lineage-specific expansions of the Dicer gene family in tardigrades
BMC GenomicsBackground RNA interference (RNAi) is an important pathway for gene regulation and immunity. Dicer is a conserved RNAi pathway protein that is found in eukaryotes, with many species expressing multiple dicer gene copies.
Bethany Weinberg +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 RNA interference (RNAi) is a cellular process involving small RNAs that target and regulate complementary RNA transcripts. This phenomenon has well-characterized roles in regulating gene and transposon expression.
Chloe Girard +6 more
doaj +1 more source
Dicer loss accelerates Kras driven ADM.
, 2014 (A). Hematoxylin and Eosin (H&E) staining of 3 week old pancreas from DicerHet and DicerHomo mice. (A) acini, (D) duct, and (I) islets. Scale bar 100 µM.
Guido von Figura (229502) +10 more
core +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction. [PDF]
PLoS ONE, 2013 Dicer endonuclease, critical for maturation of miRNAs, is depleted in certain forms of cardiomyopathy which results in differential expression of certain microRNAs.
Sashwati Roy +7 more
doaj +1 more source
Dicer restrains medulloblastoma development.
, 2015 (A) Survival curves for Ptch1+/-; Cdkn2c+/- mice with different Dicer and Nestin-Cre genotypes. Dicerfloxed/+; Nestin-Cre+; (green line, n = 51) and Dicer+/+ (red line, n = 50).
Daisuke Kawauchi (757763) +7 more
core +1 more source
Evolution of Dicer and Argonaute orthologs in microsporidian parasites [PDF]
, 2018 Microsporidia are a group of intracellular parasites which infect animal hosts. The infection can broadly influence the hosts' metabolism, growth as well as immune responses.
Huang, Qiang, Huang Q
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source