Results 51 to 60 of about 41,308 (256)
FEBS Open Bio, 2020 MicroRNAs (miRNAs) are small noncoding RNA molecules that interact with target mRNAs at specific sites to induce cleavage of the mRNA or inhibit translation.
Akira Sato +8 more
doaj +1 more source
Structures of human Drosha and Giardia Dicer.
, 2019 Front view ribbon representation of the structure of (A) Drosha and (B) Dicer. The proteins are colored with similar colors for similar domains. Domains colors are as follow: N-terminal Platform domain (Drosha: cyan, Dicer: dark blue), putative PAZ-like ...
Rotem Aharoni (8108177) +1 more
core +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Characterization of a naturally occurring truncated Dicer
, 2015 Dicer is central to small RNA silencing pathways, thus playing an important role in physiological and pathological states. Recently, a number of mutations in dicer gene have been identified in diverse types of cancer, implicating Dicer in oncogenic ...
Mosca N +5 more
core +1 more source
Arthritis Care &Research, Accepted Article.Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein +3 more
wiley +1 more source
Cause or Effect: Misregulation of MicroRNA Pathways in Neurodegeneration
Frontiers in Neuroscience, 2012 During normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway.
Fen-Biao eGao, Eduardo eGascon
doaj +1 more source
Dicer-null MEFs are viable despite suppressed proliferation.
, 2012 (A) Adeno-Cre virus was able to infect MEFs at high efficiency, judged by co-expression of GFP signal. DicerΔ/Δ MEF generated from Dicerf/f MEF by Cre excision of Dicer gene had typical cellular morphology similar to wild-type (Dicer+/+) MEF. Boxed areas
Chryssa Kanellopoulou (156457) +6 more
core +1 more source
Automated Hand Flexor Tendon–Thickness Measurement in Systemic Sclerosis
Arthritis Care &Research, EarlyView.Objective Systemic sclerosis (SSc) can affect flexor tendons, contributing to hand function problems and reduced quality of life. Tendon changes are currently assessed with ultrasonography and measured manually, a time‐consuming process prone to interobserver variability.
Mark Greveling +4 more
wiley +1 more source
A comparative study of microRNAs in different stages of Eimeria tenella
Frontiers in Veterinary Science, 2022 Apicomplexan parasites have divergent biogenesis machinery for small RNA generation. Analysis has shown that parasites in Plasmodium and Cryptosporidium as well as many species in Leishmania or Trypanosoma do not have a complete machinery in small RNA ...
Lei Zhang +6 more
doaj +1 more source
Superimposition of Drosha and Dicer.
, 2019 Front (left) and side (right) views of superimposition of Drosha (sand) upon Dicer (deep blue). Connector domain of Drosha is colored firebrick and of Dicer green-forest.
Rotem Aharoni (8108177) +1 more
core +1 more source