Results 61 to 70 of about 34,675 (262)

Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects

Viruses, 2019
Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). Specifically, virally derived dsRNA is recognized and cleaved by the enzyme Dicer2 into short interfering RNAs ...
Dulce Santos, Lina Mingels, Elise Vogel, Luoluo Wang, Olivier Christiaens, Kaat Cappelle, Niels Wynant, Yannick Gansemans, Filip Van Nieuwerburgh, Guy Smagghe, Luc Swevers, Jozef Vanden Broeck   +11 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Flexible Wide Bandgap Electrode System for In situ Cell Sensing and Irreversible Electroporation

Advanced Materials Interfaces, EarlyView.
The paper reports the design and wafer‐level microfabrication of a long‐lived, flexible 3C‐SiC electrode capable of sensitive and in situ cell sensing, as well as electroporation ablation. The work demonstrates a biocompatible and durable electrode platform that can perform reliable electrical interfacing with biological tissues over extended periods ...
Minh Anh Huynh, Sharda Yadav, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway

Biomolecules, 2020
The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson
doaj   +1 more source

Flexible Implantable Silicon Carbide Multi‐Electrode Array (MEA) for Cell Multichannel Recording and Cell Ablation

Advanced Materials Technologies, EarlyView.
Flexible silicon carbide (SiC) microelectrode arrays enable high‐fidelity, multichannel cell extracellular recording and precise localized ablation. SiC has been extensively evaluated to persist long‐term in chronic physiological conditions while remaining robust, with excellent electrical and electrochemical stability.
Minh Anh Huynh, Matthew Barton, Sharda Yadav, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +4 more
wiley   +1 more source

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism

Frontiers in Molecular Biosciences, 2019
Our genome is constantly exposed to endogenous and exogenous sources of DNA damage resulting in various alterations of the genetic code. DNA double-strand breaks (DSBs) are considered one of the most cytotoxic lesions.
Kaspar Burger, Ruth F. Ketley, Monika Gullerova   +2 more
doaj   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways

The EMBO Journal
In mammalian somatic cells, the relative contribution of RNAi and the type I interferon response during viral infection is unclear. The apparent inefficiency of antiviral RNAi might be due to self-limiting properties and mitigating co-factors of the key ...
Morgane Baldaccini, Léa Gaucherand, Béatrice Chane-Woon-Ming, Mélanie Messmer, Floriane Gucciardi, Sébastien Pfeffer   +5 more
doaj   +1 more source

Coating‐Free Nanoscratching for Liquid‐Crystal Alignment on PCB‐Compatible Millimeter‐Wave Reflective Unit Cells

Advanced Materials Technologies, EarlyView.
Direct nanoscratching with a 500 nm diamond lapping film creates groove‐guided liquid‐crystal alignment interfaces on PCB‐compatible Cu‐patterned RF substrates within minutes, eliminating polymer coating and high‐temperature baking. The coating‐free process enables optical/molecular alignment validation and voltage‐programmable 28 GHz reflection‐phase ...
Junseok Ma, Ga‐Yeong Park, Geunjung Lee, Hyo‐Won Lee, Jong‐Won Yu, Dong Ki Yoon   +5 more
wiley   +1 more source

Deterministic Integration of Quantum Emitters and Optical Cavities in a Van Der Waals Crystal

Advanced Optical Materials, EarlyView.
The work demonstrates fabrication of Circular Bragg Grating (CBG) cavities with embedded emitters in hBN. The cavities are fabricated around a pre‐characterised quantum emitter. The integrated platform enables light matter interaction and access to brighter emitters and spins in hBN.
James Liddle‐Wesolowski, Otto Cranwell Schaeper, Nathan Coste, Benjamin Whitefield, Evan Williams, Helen Zhi Jie Zeng, Mehran Kianinia, Anastasiia Zalogina, Igor Aharonovich   +8 more
wiley   +1 more source