Results 1 to 10 of about 119,642 (302)
Specific interference by ingested dsRNA
Nature, 1998 A genetic interference phenomenon in the nematode Caenorhabditis elegans has been described in which expression of an individual gene can be specifically reduced by microinjecting a corresponding fragment of double-stranded (ds) RNA1. One striking feature of this process is a spreading effect: interference in a broad region of the animal is observed ...
Andrew Z Fire
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Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
Nature, 2022 Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA-silencing mechanism in many eukaryotes1,2. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), has an ...
Jia Wang, Nan Liu, Ying Huang
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Nature CommunicationsThe escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo +8 more
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Cellular origins of dsRNA, their recognition and consequences
Nature Reviews Molecular Cell Biology, 2021 Y Grace Chen, Sun Hur
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Cell, 2015 We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a type I interferon response ...
Katherine B Chiappinelli +2 more
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Application of Double-stranded RNA (dsRNA) Produced by E. coli HT115 (DE3) and Vector L4440 in Reverse Genetics Studies in Insects [PDF]
Journal of Genetic Resources, 2023 RNA interference is a cellular process for regulating gene expression by double-stranded RNA (dsRNA). In the past two decades, this cellular process has been used as a tool for the temporary knockdown of gene expression to study gene function in reverse ...
Roohollah Abbasi
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Double-stranded RNAs are promising adjuvants for enhancing immunogenicity of vaccines
Журнал микробиологии, эпидемиологии и иммунобиологии, 2023 Background. The most effective way to prevent infectious diseases is vaccination. Adjuvants contribute to the optimization of the immune response of vaccines.
Olga N. Kaplina +3 more
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The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors
Frontiers in Bioscience-Landmark, 2023 Toll-like receptor 3 (TLR3) is a prominent member of the Toll-like receptor (TLR) family and has the ability to recognize and bind intracellular double-stranded RNA (dsRNA).
Bin Han +7 more
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Инфекция и иммунитет, 2021 A search for new targeted therapeutic strategies based on examining immunopathogenetic mechanisms for emerging co-infections is relevant and may further contribute not only to optimizing choice of immunotropic drugs, but also to achieving positive ...
I. V. Nesterova +6 more
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Artificial nanovesicles for dsRNA delivery in spray‐induced gene silencing for crop protection
Plant Biotechnology Journal, 2023 Summary Spray‐induced gene silencing (SIGS) is an innovative and eco‐friendly technology where topical application of pathogen gene‐targeting RNAs to plant material can enable disease control.
Lulu Qiao +6 more
semanticscholar +1 more source