Results 11 to 20 of about 73,913 (251)
dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA [PDF]
Viruses, 2019 RNA viruses are a major source of emerging and re-emerging infectious diseases around the world. We developed a method to identify RNA viruses that is based on the fact that RNA viruses produce double-stranded RNA (dsRNA) while replicating. Purifying and
Carolyn J. Decker +10 more
doaj +2 more sources
Frontiers in Immunology, 2018 Viruses across genome types produce long dsRNA molecules during replication [viral (v-) dsRNA]. dsRNA is a potent signaling molecule and inducer of type I interferon (IFN), leading to the production of interferon-stimulated genes (ISGs), and a protective
Sarah J. Poynter +1 more
doaj +2 more sources
A Fish MDA5 Integrates Canonical RIG-I and MDA5 Ligand Recognition. [PDF]
Adv Sci (Weinh)These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Li W +7 more
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Studying the effect of double-stranded RNA upon activity of mouse splenocytes using flow cytometry
Медицинская иммунология, 2023 Ribonucleic acids (RNA), in particular, double-stranded RNAs, due to their ability to modulate innate immune responses, are of undoubted interest in view of their usage as vaccine adjuvants.
E. S. Tsyplenkova +2 more
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Stimulating effect of double-stranded yeast RNA on the activity of interferon system genes
Медицинская иммунология, 2021 Influence of double-stranded RNA (dsRNA) from Saccharomyces cerevisiae yeast upon expression levels of the macrophage genes encoding TLR3 receptor, interferons alpha and beta (IFNα, IFNβ), 2’,5’-oligoadenylate synthetase (OAS) and protein kinase R (PKR ...
A. V. Bateneva +3 more
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RNAi-Mediated Management of Whitefly Bemisia tabaci by Oral Delivery of Double-stranded RNAs
Proceedings, 2019 The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) is a significant global pest of economically important vegetable, fibre, and ornamental crops. Whiteflies directly damage the plants by piercing and sucking essential nutrients, indirectly through ...
Ritesh G Jain +2 more
doaj +1 more source
SID-1 is a dsRNA-Selective dsRNA-gated Channel [PDF]
, 2011 Systemic RNAi in Caenorhabditis elegans requires the widely conserved transmembrane protein SID-1 to transport RNAi silencing signals between cells. When expressed in Drosophila S2 cells, C.
Joseph D. Shih +3 more
core +2 more sources
Double-stranded RNA elements associated with the MVX disease of Agaricus bisporus [PDF]
, 2003 Double-stranded RNA (dsRNA) has been isolated from Agaricus bisporus fruit bodies exhibiting a wide range of disease symptoms. The symptoms which occurred singularly or in combination included; bare cropping areas on commercial beds (primordia disruption)
Adie, Bruce A. T. +4 more
core +1 more source
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]
, 2003 Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A. +25 more
core +1 more source
European Journal of Entomology, 2017 RNA interference (RNAi) technology uses dsRNAs to silence specific targeted genes by downregulating their expression. It has become a potent tool for functional and regulatory studies of insect genes and has potential to be applied for insect control ...
Saikat Kumar B. GHOSH +1 more
doaj +1 more source