Results 1 to 10 of about 2,513,493 (257)

Interaction of PKR with single-stranded RNA

Scientific Reports, 2017
Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
doaj   +2 more sources

siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]

PLoS ONE, 2011
RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter, Vishalakshi Krishnan, Troy A Lionberger, Nils G Walter   +3 more
doaj   +1 more source

Neurodegeneration, Heterochromatin, and Double-Stranded RNA

Journal of Experimental Neuroscience, 2019
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear.
Tassa K Saldi, Patrick K Gonzales, Thomas J LaRocca, Christopher D Link   +3 more
doaj   +1 more source

A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae

Viruses, 2019
Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined.
Angela M. Crabtree, Emily A. Kizer, Samuel S. Hunter, James T. Van Leuven, Daniel D. New, Matthew W. Fagnan, Paul A. Rowley   +6 more
doaj   +1 more source

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

Open Biology, 2021
Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo, Jung In Kim, Narumi Aoki Shioi, Shigenori Iwai, Isao Kuraoka   +4 more
doaj   +1 more source

Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. [PDF]

PLoS ONE, 2014
Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes ...
Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harrison   +5 more
doaj   +1 more source

A phagocytic route for uptake of double-stranded RNA in RNAi. [PDF]

PLoS ONE, 2011
RNA interference (RNAi) has a range of physiological functions including as a defence mechanism against viruses. To protect uninfected cells in a multicellular organism, not only a cell-autonomous RNAi response is required but also a systemic one ...
João J E Rocha, Viktor I Korolchuk, Iain M Robinson, Cahir J O'Kane   +3 more
doaj   +1 more source

Sensitivity and specificity of anti-double-stranded RNA immunofluorescence for universal detection of viral infection in respiratory specimens

Heliyon, 2021
Background: Emerging viruses could be detected before reaching pandemic level if universal viral detection screening was routinely used. Double-stranded RNA (dsRNA) is the only common antigen across most viral families.
Kornthara Kawang, Udsanee Naoudom, Ekasit Kowitdamrong, Stephen J. Kerr, Kiat Ruxrungtham, Voraphoj Nilaratanakul   +5 more
doaj   +1 more source

Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients. [PDF]

PLoS ONE, 2014
Potent RNase activities were found in the serum of mammals but the physiological function of the RNases was never well illustrated, largely due to the caveats in methods of RNase activity measurement.
Weiyan Huang, Mei Zhao, Na Wei, Xiaoxia Wang, Huqing Cao, Quan Du, Zicai Liang   +6 more
doaj   +1 more source

Reverse Genetics for Double-Stranded RNA Viruses

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2009
Resumen en inglès, ver archivo ...
H. Attoui, F. Mohd Jaafar, S. Maan, P. P.C. Mertens   +3 more
doaj   +1 more source