Results 31 to 40 of about 294,686 (309)
RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. [PDF]
, 2010 Ribonucleases play important roles in the RNA interference (RNAi) pathway. The Dicer endonuclease converts double-stranded (ds)RNA into small interfering (si)RNA and the Slicer endonuclease, as a component of the RNA induced silencing complex (RISC ...
Louise E. Kemp +9 more
core +1 more source
Genome Biology, 2023 Existing single-cell RNA sequencing (scRNA-seq) methods rely on reverse transcription (RT) and second-strand synthesis (SSS) to convert single-stranded RNA into double-stranded DNA prior to amplification, with the limited RT/SSS efficiency compromising ...
Jun Lyu, Chongyi Chen
doaj +1 more source
Interaction of PKR with single-stranded RNA
Scientific Reports, 2017 Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
doaj +1 more source
siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]
PLoS ONE, 2011 RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter +3 more
doaj +1 more source
Viruses, 2019 Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined.
Angela M. Crabtree +6 more
doaj +1 more source
Open Biology, 2021 Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo +4 more
doaj +1 more source
Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. [PDF]
PLoS ONE, 2014 Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes ...
Margo C Honeyman +5 more
doaj +1 more source
A phagocytic route for uptake of double-stranded RNA in RNAi. [PDF]
PLoS ONE, 2011 RNA interference (RNAi) has a range of physiological functions including as a defence mechanism against viruses. To protect uninfected cells in a multicellular organism, not only a cell-autonomous RNAi response is required but also a systemic one ...
João J E Rocha +3 more
doaj +1 more source
Heliyon, 2021 Background: Emerging viruses could be detected before reaching pandemic level if universal viral detection screening was routinely used. Double-stranded RNA (dsRNA) is the only common antigen across most viral families.
Kornthara Kawang +5 more
doaj +1 more source
Characterization of Supercoiled Double-Stranded RNA, and Comparison to Double-Stranded DNA [PDF]
Biophysical Journal, 2011 While the mechanical properties of double-stranded DNA have been intensely studied using various single molecule assays, much less is known about double-stranded RNA (dsRNA). dsRNA is important in Biology as it forms the hereditary material for a number of viruses, and is also central to the RNA mediated gene-silencing pathway.
Skinner, Gary M. +4 more
openaire +1 more source