Results 21 to 30 of about 260,168 (263)
Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Frontiers in Drug Discovery, 2023 Mitochondrial metabolites and their derivatives have been the focus of recent efforts to develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl fumarate (DMF) and metformin have anti-inflammatory properties and have been ...
Yukun Min, Luke A. J. O’Neill
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Mismatched Double-Stranded RNA [PDF]
Drugs in R & D, 2004 Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). Ampligen, currently under development by Hemispherx Biopharma in the US, acts on the immunological system through T-lymphocyte ...
openaire +2 more sources
Tracking Cryptosporidium parvum by Sequence Analysis of Small Double-Stranded RNA
Emerging Infectious Diseases, 2001 We sequenced a 173-nucleotide fragment of the small double-stranded viruslike RNA of Cryptosporidium parvum isolates from 23 calves and 38 humans. Sequence diversity was detected at 17 sites.
Lihua Xiao +3 more
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Genome Biology, 2023 Existing single-cell RNA sequencing (scRNA-seq) methods rely on reverse transcription (RT) and second-strand synthesis (SSS) to convert single-stranded RNA into double-stranded DNA prior to amplification, with the limited RT/SSS efficiency compromising ...
Jun Lyu, Chongyi Chen
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Interaction of PKR with single-stranded RNA
Scientific Reports, 2017 Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
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siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]
PLoS ONE, 2011 RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter +3 more
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Viruses, 2019 Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined.
Angela M. Crabtree +6 more
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Open Biology, 2021 Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo +4 more
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Action of Nucleases on Double‐Stranded RNA [PDF]
European Journal of Biochemistry, 1976 Double‐stranded RNAs from Penicillium chrysogenum virus have been treated with RNAse III, pancreatic RNAse A and RNAse T1 and the degradation of the RNAs has been studied under different conditions. It was found that only the two former enzymes cut across both strands, RNase T1 cannot cleave double strands.RNase III was shown to digest double‐stranded ...
V G, Edy +3 more
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Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. [PDF]
PLoS ONE, 2014 Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes ...
Margo C Honeyman +5 more
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