Results 21 to 30 of about 419,931 (303)
UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
Nature Communications, 2021 R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role
Greg H. P. Ngo +2 more
doaj +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2023 Scientific relevance. Innate immune activation in the early phases of COVID-19 infection and subsequent interferon induction may help control viral replication and protect cells not yet infected with SARS-CoV-2.
G. M. Ignatyev +5 more
doaj +1 more source
Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase [PDF]
, 1990 Transcription from the human immunodeficiency virus type 1 promoter gives rise to short cytoplasmic transcripts of approximately 60 nucleotides as well as to longer mRNAs.
Gunnery, S. +3 more
core +1 more source
Mismatched Double-Stranded RNA [PDF]
Drugs in R & D, 2004 Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). Ampligen, currently under development by Hemispherx Biopharma in the US, acts on the immunological system through T-lymphocyte ...
openaire +2 more sources
Supercoiling Double-Stranded RNA [PDF]
Biophysical Journal, 2010 Through a novel "polymerase-stall" labeling procedure, we have successfully generated torsionally constrained molecules of double-stranded RNA (dsRNA). We have anchored these molecules within a magnetic tweezers apparatus, and by rotating the magnets, induced both positive and negative supercoils within these molecules.
Skinner, Gary M. +3 more
openaire +1 more source
Assessment of RNAi-induced silencing in banana (Musa spp.) [PDF]
, 2015 In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements.
Cammue, B.P.A. +6 more
core +1 more source
Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies [PDF]
Open Biology, 2019 RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to ...
Alison Tayler +4 more
doaj +1 more source
New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
core +2 more sources
Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Frontiers in Drug Discovery, 2023 Mitochondrial metabolites and their derivatives have been the focus of recent efforts to develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl fumarate (DMF) and metformin have anti-inflammatory properties and have been ...
Yukun Min, Luke A. J. O’Neill
doaj +1 more source
Evidence that avian reovirus σNS is an RNA chaperone: implications for genome segment assortment. [PDF]
, 2015 Reoviruses are important human, animal and plant pathogens having 10-12 segments of double-stranded genomic RNA. The mechanisms controlling the assortment and packaging of genomic segments in these viruses, remain poorly understood.
Ault, J +3 more
core +1 more source