Results 41 to 50 of about 73,913 (251)
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins
Angewandte Chemie, EarlyView.Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng +7 more
wiley +2 more sources
dsRNA and dsRNA/LyoVec upregulate expression of the RLRs RIG-I and MDA5 in BSMCs.
, 2013 BSMC were treated with dsRNA or the RLR ligand dsRNA/LyoVec (dsRNA/LV) for 24 h. mRNA (A, C) and protein (B, D) expression of RIG-I (A, B) and MDA5 (C, D) was increased concentration-dependently.
Lena Uller (83922) +2 more
core +1 more source
Advanced Science, EarlyView.The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan +9 more
wiley +1 more source
Epigenetic modifications post dsRNA transfection.
, 2015 (A)Chromatin remodeling after S1, S5 or S9 dsRNA transfection. Significant reduction in MNase digestion 72 hours after S1 and S5 transfection while increase in the accessibilty after S9 transfection in HeLa cells.
Subrata Sinha (14350) +9 more
core +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Occupancy of the dsRNA within spherules.
, 2023 (A) Volume fraction of the dsRNA, assuming a radius of 1.2 nm and using individually measured spherule volumes measured in tomograms. Each dot represents one spherule and the bar shows the mean.
Lars-Anders Carlson (236630) +1 more
core +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Analysis of Expression Patterns of PcABCG5 Gene in Penaeus chinensis Under Saline-Alkali Stress
Progress in Fishery SciencesPenaeus chinensis is one of the most economically important species in northern China. Strong market demand requires the expansion of aquaculture production capacity of P. chinensis.
Yalun LI +5 more
doaj +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source