Results 41 to 50 of about 72,832 (284)

An Investigation of Innate Immune Response of Human Blood Macrophage to Sense and Antisense dsRNA

Trends in Peptide and Protein Sciences, 2016
Silencing of gene expression by siRNA (small interfering RNA) is a powerful approach used to study the genetic analysis and functional roles of mammalian genes.
Nasrin Mohajeri, Zarrin Sharifnia, Mojgan Bandehpour, Fatemeh Yarian, Amaneh Koochaki, Nariman Mosaffa, Kazem Parivar, Bahram Kazemi   +7 more
doaj   +1 more source

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]

, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
Kay S Childs, Richard E. Randall (190211), Randall, RE, Stephen Goodbourn (411674), Goodbourn, Stephen, Kay S. Childs (411673), Richard E. R, Goodbourn, S, Childs, Kay S., Childs Kay S., Richard E Randall, Randall Richard E., Randall, Richard E., Kay S. Childs, Stephen Goodbourn, Childs, KS, Goodbourn Stephen   +16 more
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RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
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Application of a dsRNAs-induced RNAi method for acetolactate synthase (ALS) gene silencing in Amaranthus hybridus L. [PDF]

, 2022
openRNAi is a natural gene silencing pathway that can be taken advantage of for weed control in agriculture. Since RNAi can be triggered by the application of exogenous dsRNA to induce PTGS, the aim of the study is to develop a method for ALS ...
ZANOVELLO, LAURA
core  

Mechanism of PKR Activation by dsRNA [PDF]

Journal of Molecular Biology, 2008
Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway. Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation reactions that activate the kinase. PKR then phosphorylates eukaryotic initiation factor 2alpha, thus inhibiting protein synthesis in virally infected cells.
Peter A, Lemaire, Eric, Anderson, Jeffrey, Lary, James L, Cole   +3 more
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dsRNA injection specifications in Bivalves

, 2021
Experimental conditions and specifications for dsRNA injection in bivalves for gene silencing assays. Data extracted from publications from 2009 to 2018.
Otto Heringer
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(A,B) RNA profiling (RNAseq analysis) of CYP3-dsRNA-derived RNAs in local and distal tissue of CYP3-dsRNA-treated barley leaves on Illumina HiSeq.

, 2016
Higher numbers of reads of CYP3-dsRNA-derived sRNAs were found in infected vs. non-infected leaves both in the sprayed (local [A]) and non-sprayed (semi-systemic [B]) leaf area at 6 dpi with strain Fg-IFA65.
John McMillan (3217584), Dagmar Biedenkopf (201484), Aline Koch (3217596), Vinitha Cardoza (3217605), Eltayb Abdellatef (3217602), Lennart Weber (479942), Alexandra Furch (3217590), Karl-Heinz Kogel (54116), Lukas Jelonek (839039), Alexander Goesmann (11354), Lukas Linicus (3217587), Tobias Mentzel (3217593), Jan Johannsmeier (3217581), Oliver Rossbach (3217599)   +13 more
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dsRNA in immunometabolism

Oncotarget, 2015
The worldwide prevalence of obesity has reached pandemic proportions, and with it have come other associated metabolic diseases, such as insulin resistance and type 2 diabetes (T2D). Intensive research has identified the frequent coexistence of obesity with a state of inflammation in metabolic tissues such as adipose tissue and liver [1].
openaire   +2 more sources

(A,B) Northern gel blot analysis of CYP3-dsRNA and CYP3-dsRNA-derived siRNA accumulation in local and distal (semi-systemic) barley leaf areas.

, 2016
(A) Detection of 791 nt long CYP3-dsRNA precursor in pooled leaf tissue from non-infected leaves using [α-32P]-dCTP labeled CYP3-dsRNA as probe. Local (L) and distal (semi-systemic [S]) leaf segments were sampled separately at the indicated times after ...
John McMillan (3217584), Dagmar Biedenkopf (201484), Aline Koch (3217596), Vinitha Cardoza (3217605), Eltayb Abdellatef (3217602), Lennart Weber (479942), Alexandra Furch (3217590), Karl-Heinz Kogel (54116), Lukas Jelonek (839039), Alexander Goesmann (11354), Lukas Linicus (3217587), Tobias Mentzel (3217593), Jan Johannsmeier (3217581), Oliver Rossbach (3217599)   +13 more
core   +1 more source

Formation of Double Stranded RNA Provokes Smooth Muscle Contractions and Structural Modifications in Bladder Ischemia

Research and Reports in Urology, 2022
Jing-Hua Yang,1 Zuohui Zhao,2 Wanting Niu,3 Han-Pil Choi,3 Kazem M Azadzoi4 1Department of Surgery, Boston University School of Medicine and Proteomics Laboratory, VA Boston Healthcare System, Boston, MA, USA; 2Department of Urology, Boston University ...
Yang JH, Zhao Z, Niu W, Choi HP, Azadzoi KM   +4 more
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