Results 1 to 10 of about 15,291 (116)

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

Cells, 2019
Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis.
Soo Jung Cho, Jong-Seok Moon, Choi Augustine M K   +2 more
exaly   +3 more sources

DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break

Cell Reports
Summary: The activation of the DNA-damage response (DDR) enforces the transcriptional silencing of genes near DNA double-strand breaks (DSBs), a process called DSB-induced silencing in cis (DISC).
Francesca Esposito, Ilaria Capozzo, Adelaide Riccardi, Ubaldo Gioia, Stefania Modafferi, Letizia Manfredi, Alessio Colantoni, Sara Tavella, Matteo Cabrini, Fabio Iannelli, Alessia di Lillo, Fabrizio d’Adda di Fagagna, Sofia Francia   +12 more
doaj   +2 more sources

Association of DROSHA Variants with Susceptibility and Outcomes in Childhood Acute Lymphoblastic Leukemia [PDF]

Current Issues in Molecular Biology
MicroRNAs are key regulators of lymphoid differentiation, exhibiting a pivotal role in acute lymphoblastic leukemia (ALL) biology and prognosis. The initial steps of canonical miRNA biogenesis involve the microprocessor complex processing the primary ...
Ioannis Kyriakidis, Iordanis Pelagiadis, Charalampos Pontikoglou, Helen A. Papadaki, Eftichia Stiakaki   +4 more
doaj   +2 more sources

High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism

Cells, 2021
Diabetes promotes an angiostatic phenotype in the microvascular endothelium of skeletal muscle and skin. Angiogenesis-related microRNAs (angiomiRs) regulate angiogenesis through the translational repression of pro- and anti-angiogenic genes.
Brian Lam, Emmanuel Nwadozi, Tara L. Haas, Olivier Birot, Emilie Roudier   +4 more
doaj   +1 more source

The differential expression and effects of Drosha on metamorphosis of Japanese flounder (paralichthys olivaceus)

Frontiers in Marine Science, 2022
Drosha is critical for producing mature microRNAs (miRNAs) from their precursor molecules and small interfering RNAs (siRNAs). Although Drosha has been well characterized in most vertebrate species, identifying the Japanese flounder Drosha has remained ...
Hongmei Zhang, Zhaobin Xu, Junxiao Xu, Zhenlin Wei, Zhiyi Shi   +4 more
doaj   +1 more source

DROSHA but not DICER is required for human haematopoietic stem cell function

Clinical & Translational Immunology, 2022
Objectives DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messenger (m)RNAs ...
Karen Gu, Carina Walpole, Shayarana Gooneratne, Xin Liu, Oscar L Haigh, Kristen J Radford, Mark MW Chong   +6 more
doaj   +1 more source

Essential role of the amino-terminal region of Drosha for the Microprocessor function

iScience, 2023
Summary: Drosha is a core component of the Microprocessor complex that cleaves primary-microRNAs (pri-miRNAs) to generate precursor-miRNA and regulates the expression of ∼80 ribosomal protein (RP) genes.
Amit Prabhakar, Song Hu, Jin Tang, Prajakta Ghatpande, Giorgio Lagna, Xuan Jiang, Akiko Hata   +6 more
doaj   +1 more source

miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival. [PDF]

PLoS ONE, 2013
miRNA biogenesis enzyme Drosha cleaves double-stranded primary miRNA by interacting with double-stranded RNA binding protein DGCR8 and processes primary miRNA into precursor miRNA to participate in the miRNA biogenesis pathway.
Pei Fan, Zixuan Chen, Peng Tian, Wen Liu, Yan Jiao, Yi Xue, Anindya Bhattacharya, Jianmin Wu, Meifen Lu, Yuqi Guo, Yan Cui, Weikuan Gu, Weiwang Gu, Junming Yue   +13 more
doaj   +1 more source

Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk. [PDF]

PLoS ONE, 2013
PURPOSE: miRNAs can regulate the biological processes, including differentiation, proliferation and apoptosis. DICER and DROSHA are two members of RNase III family, playing pivotal roles in the pathway of miRNAs biogenesis. In this study, we hypothesized
Lin Yuan, Haiyan Chu, Meilin Wang, Xiaojian Gu, Danni Shi, Lan Ma, Dongyan Zhong, Mulong Du, Pu Li, Na Tong, Guangbo Fu, Chao Qin, Changjun Yin, Zhengdong Zhang   +13 more
doaj   +1 more source

Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination. [PDF]

PLoS ONE, 2013
The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing.
Xiaoli Tang, Sicheng Wen, Dong Zheng, Lynne Tucker, Lulu Cao, Dennis Pantazatos, Steven F Moss, Bharat Ramratnam   +7 more
doaj   +1 more source