Results 1 to 10 of about 317 (89)

High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism

Cells, 2021
Diabetes promotes an angiostatic phenotype in the microvascular endothelium of skeletal muscle and skin. Angiogenesis-related microRNAs (angiomiRs) regulate angiogenesis through the translational repression of pro- and anti-angiogenic genes.
Brian Lam, Emmanuel Nwadozi, Tara L. Haas, Olivier Birot, Emilie Roudier   +4 more
doaj   +1 more source

The differential expression and effects of Drosha on metamorphosis of Japanese flounder (paralichthys olivaceus)

Frontiers in Marine Science, 2022
Drosha is critical for producing mature microRNAs (miRNAs) from their precursor molecules and small interfering RNAs (siRNAs). Although Drosha has been well characterized in most vertebrate species, identifying the Japanese flounder Drosha has remained ...
Hongmei Zhang, Zhaobin Xu, Junxiao Xu, Zhenlin Wei, Zhiyi Shi   +4 more
doaj   +1 more source

DROSHA but not DICER is required for human haematopoietic stem cell function

Clinical & Translational Immunology, 2022
Objectives DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messenger (m)RNAs ...
Karen Gu, Carina Walpole, Shayarana Gooneratne, Xin Liu, Oscar L Haigh, Kristen J Radford, Mark MW Chong   +6 more
doaj   +1 more source

Essential role of the amino-terminal region of Drosha for the Microprocessor function

iScience, 2023
Summary: Drosha is a core component of the Microprocessor complex that cleaves primary-microRNAs (pri-miRNAs) to generate precursor-miRNA and regulates the expression of ∼80 ribosomal protein (RP) genes.
Amit Prabhakar, Song Hu, Jin Tang, Prajakta Ghatpande, Giorgio Lagna, Xuan Jiang, Akiko Hata   +6 more
doaj   +1 more source

miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival. [PDF]

PLoS ONE, 2013
miRNA biogenesis enzyme Drosha cleaves double-stranded primary miRNA by interacting with double-stranded RNA binding protein DGCR8 and processes primary miRNA into precursor miRNA to participate in the miRNA biogenesis pathway.
Pei Fan, Zixuan Chen, Peng Tian, Wen Liu, Yan Jiao, Yi Xue, Anindya Bhattacharya, Jianmin Wu, Meifen Lu, Yuqi Guo, Yan Cui, Weikuan Gu, Weiwang Gu, Junming Yue   +13 more
doaj   +1 more source

Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk. [PDF]

PLoS ONE, 2013
PURPOSE: miRNAs can regulate the biological processes, including differentiation, proliferation and apoptosis. DICER and DROSHA are two members of RNase III family, playing pivotal roles in the pathway of miRNAs biogenesis. In this study, we hypothesized
Lin Yuan, Haiyan Chu, Meilin Wang, Xiaojian Gu, Danni Shi, Lan Ma, Dongyan Zhong, Mulong Du, Pu Li, Na Tong, Guangbo Fu, Chao Qin, Changjun Yin, Zhengdong Zhang   +13 more
doaj   +1 more source

Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination. [PDF]

PLoS ONE, 2013
The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing.
Xiaoli Tang, Sicheng Wen, Dong Zheng, Lynne Tucker, Lulu Cao, Dennis Pantazatos, Steven F Moss, Bharat Ramratnam   +7 more
doaj   +1 more source

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

RNA Biology, 2022
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu   +6 more
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Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer

Frontiers in Molecular Biosciences, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang, Fanming Yang, Fanzou Liu, Qiuhuan Tian, Min Hu, Peng Li, Yan Zeng   +6 more
doaj   +1 more source

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

Cells, 2019
Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis.
Soo Jung Cho, Kyoung Sook Hong, Ji Hun Jeong, Mihye Lee, Augustine M. K. Choi, Heather W. Stout-Delgado, Jong-Seok Moon   +6 more
doaj   +1 more source