Results 11 to 20 of about 17,302 (170)

Drosha promotes splicing of a pre-microRNA-like alternative exon.

PLoS Genetics, 2014
The ribonuclease III enzyme Drosha has a central role in the biogenesis of microRNA (miRNA) by binding and cleaving hairpin structures in primary RNA transcripts into precursor miRNAs (pre-miRNAs).
Mallory A Havens, Ashley A Reich, Michelle L Hastings   +2 more
doaj   +2 more sources

Unveiling isoleucyl-tRNA synthetase 2 as a novel driver of breast cancer via β-catenin pathway activation. [PDF]

J Cell Commun Signal
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Yang X, Wang Y, Yi Y, Yang Y, Wang H.
europepmc   +2 more sources

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

RNA Biology, 2022
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu   +6 more
doaj   +1 more source

Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer

Frontiers in Molecular Biosciences, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Xiaoxiao Zhang, Fanming Yang, Fanzou Liu, Qiuhuan Tian, Min Hu, Peng Li, Yan Zeng   +6 more
doaj   +1 more source

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]

Open Biology, 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson, Andrew M. Lew, Mark M. W. Chong   +2 more
doaj   +1 more source

Essential role of the amino-terminal region of Drosha for the Microprocessor function

, 2022
Summary: The ribonuclease (RNase) III enzyme Drosha enables processing of microRNA (miRNA) primary transcripts (pri-miRNAs) and control of ribosomal protein (RP) biogenesis by the Microprocessor.
Hata, Akiko, Tang, Jin, Jiang, Xuan, Prabhakar, Amit, Ghatpande, Prajakta, Hu, Song, Lagna, Giorgio   +6 more
core   +1 more source

Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway

Biomolecules, 2020
The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson
doaj   +1 more source

Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8 [PDF]

, 2022
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis.
Partin, Alexander Christian
core   +1 more source

Genetic Variants of MicroRNA and DROSHA Genes in Association With the Risk of Tuberculosis in the Amazon Population

Frontiers in Genetics, 2022
Tuberculosis (TB) is a chronic infection caused by Mycobacterium tuberculosis (Mtb) with high incidence and mortality. Studies reported that host genetic variants might be associated with the risk of tuberculosis.
Diana Feio da Veiga Borges Leal, Mayara Natália Santana da Silva, Lucas Favacho Pastana, Marianne Rodrigues Fernandes, Aidalucy do Socorro Costa de Athayde, Débora Christina Ricardo Fernandes Porchera, Cleonardo Augusto da Silva, Antônio André Conde Modesto, Paulo Pimentel De Assumpcão, Sidney Emanuel Batista dos Santos, Sidney Emanuel Batista dos Santos, Ney Pereira Carneiro dos Santos   +11 more
doaj   +1 more source

Structure of human DROSHA

, 2015
MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor.
Yeon-Gil Choi, Tuan Anh Nguyen, Sungchul Hohng, S. Chul Kwon, V. Narry Kim, Jae-Sung Woo, Myung Hyun Jo, Woo, Jae Sung, Kim, V. Narry, Choi, Yeon Gil, Choi, Yeon-Gil, Hohng, Sungchul, Nguyen, Tuan Anh, Woo, Jae-Sung, Jo, Myung Hyun, Kwon, S. Chul   +15 more
core   +2 more sources