Results 11 to 20 of about 15,397 (180)

DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break

Cell Reports
Summary: The activation of the DNA-damage response (DDR) enforces the transcriptional silencing of genes near DNA double-strand breaks (DSBs), a process called DSB-induced silencing in cis (DISC).
Francesca Esposito, Ilaria Capozzo, Adelaide Riccardi, Ubaldo Gioia, Stefania Modafferi, Letizia Manfredi, Alessio Colantoni, Sara Tavella, Matteo Cabrini, Fabio Iannelli, Alessia di Lillo, Fabrizio d’Adda di Fagagna, Sofia Francia   +12 more
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Drosha: a new tumor suppressor in pineoblastoma [PDF]

Genes & Development
To investigate the pathogenesis and target the vulnerability of human pineoblastoma, researchers have developed multiple genetically engineered mouse models that represent distinct molecular subtypes of the disease. In this issue ofGenes & Development, Fraire and colleagues (doi:10.1101/gad.352485.124) examined the roles of key microRNA (miRNA ...
Huang, Zhixuan, Ren, Xueli, Hu, Jian
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Association of DROSHA Variants with Susceptibility and Outcomes in Childhood Acute Lymphoblastic Leukemia [PDF]

Current Issues in Molecular Biology
MicroRNAs are key regulators of lymphoid differentiation, exhibiting a pivotal role in acute lymphoblastic leukemia (ALL) biology and prognosis. The initial steps of canonical miRNA biogenesis involve the microprocessor complex processing the primary ...
Ioannis Kyriakidis, Iordanis Pelagiadis, Charalampos Pontikoglou, Helen A. Papadaki, Eftichia Stiakaki   +4 more
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Structure of Human DROSHA [PDF]

Cell, 2016
MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor. Here, we report the X-ray structure of DROSHA in complex with the C-terminal helix of DGCR8. We find that DROSHA contains two DGCR8-binding sites, one
Kwon, S. Chul, Nguyen, Tuan Anh, Choi, Yeongil, Jo, Myunghyun, Hohng, Sungchul C., Kim, V. Narry, Woo, Jae-Sung   +6 more
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Drosha in Primary MicroRNA Processing [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2006
MicroRNA (miRNA)-mediated gene silencing is one of the major regulatory pathways in eukaryotes. Much effort has been made to identify the factors involved in the pathway, and our understanding of RNA silencing has significantly advanced in recent years.
Y, Lee, J, Han, K-H, Yeom, H, Jin, V N, Kim   +4 more
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Posttranscriptional Crossregulation between Drosha and DGCR8 [PDF]

Cell, 2009
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these ...
Han, Jinju, Pedersen, Jakob S, Kwon, S Chul, Belair, Cassandra D, Kim, Young-Kook, Yeom, Kyu-Hyeon, Yang, Woo-Young, Haussler, David, Blelloch, Robert, Kim, V Narry   +9 more
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Predicting Drosha and Dicer Cleavage Sites with DeepMirCut [PDF]

Frontiers in Molecular Biosciences, 2022
MicroRNAs are a class of small RNAs involved in post-transcriptional gene silencing with roles in disease and development. Many computational tools have been developed to identify novel microRNAs. However, there have been no attempts to predict cleavage sites for Drosha from primary sequence, or to identify cleavage sites using deep neural networks ...
Jimmy Bell, David A. Hendrix, David A. Hendrix   +2 more
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Drosha as an interferon-independent antiviral factor [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Virus infections must be combated at a cellular level. The strategies used to inhibit virus differ dramatically when comparing plants and insects to mammals. Here, we identify an evolutionary conserved antiviral response that is independent of these known defenses.
Jillian S, Shapiro, Sonja, Schmid, Lauren C, Aguado, Leah R, Sabin, Ari, Yasunaga, Jaehee V, Shim, David, Sachs, Sara, Cherry, Benjamin R, tenOever   +8 more
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Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology [PDF]

Cells, 2021
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders, which are characterized by accumulation of somatic mutations. The acquired mutation burden is suggested to define the pathway and consequent phenotype of the pathology.
Dmitrii S. Bug, Artem V. Tishkov, Ivan S. Moiseev, Yuri B. Porozov, Natalia V. Petukhova   +4 more
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Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer [PDF]

New England Journal of Medicine, 2008
We studied Dicer and Drosha, components of the RNA-interference machinery, in ovarian cancer.We measured messenger RNA (mRNA) levels of Dicer and Drosha in specimens of invasive epithelial ovarian cancer from 111 patients, using a quantitative reverse-transcriptase-polymerase-chain-reaction assay, and compared the results with clinical outcomes ...
Merritt, W.M., Lin, Y.G., Han, L.Y., Karnat, Aa., Spannuth, W.A., Schmandt, R., Urbauer, D., Pennacchio, L.A., Cheng, J.-F., Nick, A.M., Deavers, M.T., Mourad-Seidan, A., Wang, H., Mueller, P., Lenburg, M.E., Gray, J.W., Mok, S., Birrer, M.J., Lopez-Berestein, G., Coleman, R.L., Bar-Eli, M., Sood, A.K.   +21 more
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