Results 1 to 10 of about 31,524 (103)

Network Regulation of microRNA Biogenesis and Target Interaction [PDF]

Cells, 2023
MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression. Canonical miRNAs are generated through the two-step DROSHA- and DICER-mediated processing of primary miRNA (pri-miRNA) transcripts with optimal or suboptimal features ...
Hiroshi Suzuki, Shintaro Komatsu
exaly   +4 more sources

Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway [PDF]

Biomolecules, 2020
The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson, Meerson Ari
exaly   +4 more sources

microRNA biogenesis and stabilization in plants [PDF]

Fundamental Research, 2023
MicroRNAs (miRNAs) are short endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level in a broad range of eukaryotic species.
Ye Xu, Xuemei Chen
doaj   +2 more sources

A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viral pathogenesis [PDF]

Nature Communications
Liquid-liquid phase separation (LLPS) regulates diverse biological functions by mediating the assembly of biomolecular condensates. However, it remains unclear how host LLPS is targeted by viruses during infection.
Jing Zou, Shuai Zhang, Ying Chen, Chun He, Xin Pan, Yimin Zhang, Jianwei Xu, Lijia Zheng, Hongxin Guan, Ming Wu, Dongqi Xie, Yinghua Ji, Xianyang Fang, Yi Li, Shou-wei Ding, Xiaofeng Fang, Shanshan Zhao, Jianguo Wu   +17 more
doaj   +2 more sources

Regulatory role of RNA-binding proteins in microRNA biogenesis [PDF]

Frontiers in Molecular Biosciences
MicroRNAs (miRNAs) are small non-coding RNAs that silence gene expression through their interaction with complementary sequences in the 3′ untranslated regions (UTR) of target mRNAs. miRNAs undergo a series of steps during their processing and maturation,
Claire Hynes, Pavan Kumar Kakumani
doaj   +2 more sources

MicroRNA biogenesis and variability

Biomolecular Concepts, 2013
MicroRNAs (miRNAs) are cell-endogenous small noncoding RNAs that, through RNA interference, are involved in the posttranscriptional regulation of mRNAs.
Jesus Garcia Lopez, MIGUEL Angel Brieno-Enriquez, Jesus Del Mazo   +2 more
exaly   +2 more sources

MicroRNA Biogenesis, Gene Regulation Mechanisms, and Availability in Foods [PDF]

Non-Coding RNA
MicroRNAs (miRNAs) are small, non-coding RNAs that control gene expression by degrading or repressing mRNA translation into proteins. Research recently suggested that food-derived miRNAs are bioavailable and may be absorbed in the gastrointestinal tract (
Amilton S. de Mello, Bradley S. Ferguson, Erica L. Shebs-Maurine, Francine M. Giotto   +3 more
doaj   +2 more sources

DNA methylation directs microRNA biogenesis in mammalian cells [PDF]

Nature Communications, 2019
Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA ...
Ohad Glaich, Shivang Parikh, Rachel E. Bell, Keren Mekahel, Maya Donyo, Yodfat Leader, Ronna Shayevitch, Danna Sheinboim, Sivan Yannai, Dror Hollander, Ze’ev Melamed, Galit Lev-Maor, Gil Ast, Carmit Levy   +13 more
doaj   +2 more sources

PLK1 Regulates MicroRNA Biogenesis through Drosha Phosphorylation [PDF]

International Journal of Molecular Sciences, 2023
Charlotte Bevan, Molly Taylor, Claire Fletcher   +2 more
exaly   +2 more sources

The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases [PDF]

International Journal of Molecular Sciences, 2023
Yijuang Chern, Yao-Ming Chang, Chang Yao-Ming   +2 more
exaly   +2 more sources