Results 21 to 30 of about 31,514 (218)
microRNA Biogenesis and Turnover in Plants [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2012 microRNAs (miRNAs) are short RNAs that regulate gene expression in eukaryotes. The biogenesis and turnover of miRNAs determine their spatiotemporal accumulation within tissues. miRNA biogenesis is a multistep process that entails transcription, processing, nuclear export, and formation of the miRNA-ARGONAUTE complex.
K, Rogers, X, Chen
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MicroRNA biogenesis: regulating the regulators [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2012 MicroRNAs (miRNAs) function as 21-24 nucleotide guide RNAs that use partial base-pairing to recognize target messenger RNAs and repress their expression. As a large fraction of protein-coding genes are under miRNA control, production of the appropriate level of specific miRNAs at the right time and in the right place is integral to most gene regulatory
Emily F, Finnegan, Amy E, Pasquinelli
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Mechanisms of control of microRNA biogenesis [PDF]
Journal of Biochemistry, 2010 MicroRNAs (miRNAs) are a class of ∼22 nt non-coding RNAs that control diverse biological functions in animals, plants and unicellular eukaryotes by promoting degradation or inhibition of translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated.
Brandi N, Davis-Dusenbery, Akiko, Hata
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MicroRNAs: Biogenesis and Molecular Functions [PDF]
Brain Pathology, 2008 AbstractSmall regulatory RNAs are essential and ubiquitous riboregulators that are the key mediators of RNA interference (RNAi). They include microRNAs (miRNAs) and short‐interfering RNAs (siRNAs), classes of ∼22 nucleotide RNAs. miRNAs and siRNAs bind to Argonaute proteins and form effector complexes that regulate gene expression; in animals, this ...
Xuhang, Liu +2 more
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Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
Cell Communication and Signaling, 2009 microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses.
Davis Brandi N, Hata Akiko
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Interplay between RNA interference and heat shock response systems in Drosophila melanogaster [PDF]
Open Biology, 2016 The genome expression pattern is strongly modified during the heat shock response (HSR) to form an adaptive state. This may be partly achieved by modulating microRNA levels that control the expression of a great number of genes that are embedded within ...
S. Yu Funikov +9 more
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The MicroRNA Family Gets Wider: The IsomiRs Classification and Role
Frontiers in Cell and Developmental Biology, 2021 MicroRNAs (miRNAs or miRs) are the most characterized class of non-coding RNAs and are engaged in many cellular processes, including cell differentiation, development, and homeostasis.
Luisa Tomasello +3 more
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Regulation of cardiac microRNAs by serum response factor
Journal of Biomedical Science, 2011 Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in cardiac hypertrophy has not been well ...
Wei Jeanne Y +3 more
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Cepred: predicting the co-expression patterns of the human intronic microRNAs with their host genes. [PDF]
PLoS ONE, 2009 Identifying the tissues in which a microRNA is expressed could enhance the understanding of the functions, the biological processes, and the diseases associated with that microRNA.
Dong Wang +5 more
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MicroRNA biogenesis and cellular proliferation [PDF]
Translational Research, 2015 Given the fundamental roles of microRNAs (miRNAs) in physiological, developmental, and pathologic processes, we hypothesized that genes involved in miRNA biogenesis contribute to human complex traits. For 13 such genes, we evaluated the relationship between transcription and 2 classes of complex traits, namely cellular growth and sensitivity to various
Divya, Lenkala +4 more
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