Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway [PDF]
Biomolecules, 2020 The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson
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DNA methylation directs microRNA biogenesis in mammalian cells [PDF]
Nature Communications, 2019 Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA ...
Ohad Glaich +13 more
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PLK1 Regulates MicroRNA Biogenesis through Drosha Phosphorylation [PDF]
International Journal of Molecular Sciences, 2023 Claire E Fletcher +2 more
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The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2023 Yao-Ming Chang +2 more
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Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development [PDF]
International Journal of Molecular Sciences, 2021 Yue Feng
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Antioxidants, 2023 Ischemic cardiomyopathy (ICM) is associated with abnormal microRNA expression levels that involve an altered gene expression profile. However, little is known about the underlying causes of microRNA disruption in ICM and whether microRNA maturation is ...
Lorena Pérez-Carrillo +10 more
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MicroRNA Biogenesis and Cancer [PDF]
Cancer Research, 2005 Abstract MicroRNAs (miRNA) are a recently discovered family of short non–protein-coding RNAs that negatively regulate gene expression. Recent studies of miRNAs highlight a requirement for cell viability. Posttranscriptional silencing of target genes by miRNAs occurs either by targeting specific cleavage of homologous mRNAs, or by ...
Richard I, Gregory, Ramin, Shiekhattar
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MicroRNA clustering on the biogenesis of suboptimal microRNAs [PDF]
Applied Biological Chemistry, 2021 AbstractMost microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures ...
Sehee Park, Igojo Kang, Chanseok Shin
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The role of microRNAs in learning and long-term memory
Вавиловский журнал генетики и селекции, 2020 The mechanisms of long-term memory formation and ways to improve it (in the case of its impairment) remain an extremely difficult problem yet to be solved. Over the recent years, much attention has been paid to microRNAs in this regard.
L. N. Grinkevich
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Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis [PDF]
Терапевтический архив, 2018 Aim. To study the expression level of the genes DROSHA and DICER in peripheral blood leukocytes (PBL) of patients with sarcoidosis of the lungs Materials and methods.
I E Malysheva +3 more
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