Results 1 to 10 of about 183 (85)
A Review of IsomiRs in Colorectal Cancer
Non-coding RNA, 2023 As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template ...
Bruce Boman, Boman Bruce M
exaly +3 more sources
RNA Biology, 2022 microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through translational repression and mRNA destabilization. During canonical miRNA biogenesis, several miRNA isoforms, or isomiRs, are produced from a single precursor miRNA ...
Ganesh Panzade +2 more
exaly +2 more sources
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role
Frontiers in Cell and Developmental Biology, 2021 MicroRNAs (miRNAs or miRs) are the most characterized class of non-coding RNAs and are engaged in many cellular processes, including cell differentiation, development, and homeostasis.
Rosario Distefano +2 more
exaly +3 more sources
isomiRTar: a comprehensive portal of pan-cancer 5′-isomiR targeting [PDF]
PeerJ, 2022 Inaccurate cleavage of pri- and pre-miRNA hairpins by Drosha and Dicer results in the generation of miRNA isoforms known as isomiRs. isomiRs with 5′-end variations (5′-isomiRs) create a new dimension in miRNA research since they have different seed ...
Stepan Nersisyan +5 more
doaj +2 more sources
Identification and Elucidation of the Protective isomiRs in Lung Cancer Patient Prognosis
Frontiers in Genetics, 2021 MicroRNAs (miRNAs) are approximately 20–22 nucleotides in length, which are well known to participate in the post-transcriptional modification. The mature miRNAs were observed to be varied on 5′ or 3′ that raise another term—the isoforms of mature miRNAs
Fu-Mei Hsieh +3 more
doaj +1 more source
Biogenesis and biological implications of isomiRs in mammals- a review [PDF]
ExRNA, 2019 Background: IsomiRs, the sequence-variants of microRNA (miRNA), are characterized by variation at the 3′- and/or 5′-end(s) of canonical miRNA-sequence as a result of nucleotide addition or deletion or substitution.
Jasdeep Kaur Dhanoa +4 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns.
Tingming Liang, Leng Han, Li Guo
doaj +1 more source
A comprehensive survey of miRNA repertoire and 3' addition events in the placentas of patients with pre-eclampsia from high-throughput sequencing. [PDF]
PLoS ONE, 2011 BackgroundTo gain insight into potential roles of isomiR spectrum and isomiRs with 3' additions in pre-eclampsia, we performed a comprehensive survey of miRNA repertoire and 3' addition events from placental samples with different degrees of pre ...
Li Guo +7 more
doaj +1 more source
Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma
Computational and Structural Biotechnology Journal, 2021 Cholangiocarcinomas (CCAs) are tumors that arise from the cholangiocytes. Although some genes have been shown with important roles in pathological process, interactions or cross-talks among different RNAs are important to understand the detailed ...
Li Guo +11 more
doaj +1 more source
BMC Bioinformatics, 2021 Background Next generation sequencing has allowed the discovery of miRNA isoforms, termed isomiRs. Some isomiRs are derived from imprecise processing of pre-miRNA precursors, leading to length variants.
Jose Francisco Sanchez Herrero +3 more
doaj +1 more source