Results 1 to 10 of about 129 (84)

A novel approach for a joint analysis of isomiR and mRNA expression data reveals features of isomiR targeting in breast cancer

Frontiers in Genetics, 2022
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples.
Diana Maltseva, Alexander Tonevitsky, Stepán Nersisyan   +2 more
exaly   +3 more sources

A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia

BMC Genomics, 2018
Background MicroRNA (miRNA) profiling is an important step in studying biological associations and identifying marker candidates. miRNA exists in isoforms, called isomiRs, which may exhibit distinct properties.
Douglas Mahoney, Thomas Smyrk, John Kisiel   +2 more
exaly   +3 more sources

miRglmm: a generalized linear mixed model of isomiR-level counts improves estimation of miRNA-level differential expression and uncovers variable differential expression between isomiRs

Genome Biology
MicroRNA-seq data is produced by aligning small RNA sequencing reads of different microRNA transcript isoforms, called isomiRs, to known microRNAs. Aggregation to microRNA-level counts discards information and violates core assumptions of differential ...
Matthew N Mccall, Marc Halushka, Baran Andrea M   +2 more
exaly   +2 more sources

New characteristics of MiRNA and IsomiR interactions with mRNA

Scientific Reports
Studying the interactions between microRNAs/isomiRs and mRNAs is crucial due to their fundamental roles in gene regulation and disease. Although many isomiRs have been identified, the analysis of their interactions with mRNAs remains in its early stages.
Haiyan Hu, Li Xiaoman
exaly   +2 more sources

Circulating extracellular vesicle isomiR signatures predict therapy response in patients with multiple myeloma

Cell Reports Medicine
Summary: Multiple myeloma (MM) is a plasma cell neoplasm characterized by high inter- and intra-patient clonal heterogeneity, leading to high variability in therapeutic responses.
Dirk Pegtel
exaly   +3 more sources

isomiRTar: a comprehensive portal of pan-cancer 5′-isomiR targeting [PDF]

PeerJ, 2022
Inaccurate cleavage of pri- and pre-miRNA hairpins by Drosha and Dicer results in the generation of miRNA isoforms known as isomiRs. isomiRs with 5′-end variations (5′-isomiRs) create a new dimension in miRNA research since they have different seed ...
Stepan Nersisyan, Aleksandra Gorbonos, Alexey Makhonin, Anton Zhiyanov, Maxim Shkurnikov, Alexander Tonevitsky   +5 more
doaj   +2 more sources

Extensive downregulation of immune gene expression by microRNA-140-3p 5′ isomiR in an in vitro model of osteoarthritis

Osteoarthritis and Cartilage Open, 2021
Objective: MicroRNA-140-3p is the most prevalent form of canonical miR-140 in native chondrocytes. IsomiRs are sequence variants of microRNAs with potentially distinct functionalities.
Rua Nader Al-Modawi, Jan E. Brinchmann, Tommy A. Karlsen   +2 more
doaj   +1 more source

IsomiR_Window: a system for analyzing small-RNA-seq data in an integrative and user-friendly manner

BMC Bioinformatics, 2021
Background IsomiRs are miRNA variants that vary in length and/or sequence when compared to their canonical forms. These variants display differences in length and/or sequence, including additions or deletions of one or more nucleotides (nts) at the 5 ...
Ana M. Vasconcelos, Maria Beatriz Carmo, Beatriz Ferreira, Inês Viegas, Margarida Gama-Carvalho, António Ferreira, Andreia J. Amaral   +6 more
doaj   +1 more source

Coupling miR/isomiR and mRNA Expression Signatures Unveils New Molecular Layers of Endometrial Receptivity

Life, 2021
Embryo implantation depends on endometrial receptivity (ER). To achieve ER, the preparation of the uterine lining requires controlled priming by ovarian hormones and the expression of numerous genes in the endometrial tissue.
Maria Nikolova, Mladen Naydenov, Ilias Glogovitis, Apostol Apostolov, Merli Saare, Nageswara Boggavarapu, Andres Salumets, Vesselin Baev, Galina Yahubyan   +8 more
doaj   +1 more source

Biogenesis and biological implications of isomiRs in mammals- a review [PDF]

ExRNA, 2019
Background: IsomiRs, the sequence-variants of microRNA (miRNA), are characterized by variation at the 3′- and/or 5′-end(s) of canonical miRNA-sequence as a result of nucleotide addition or deletion or substitution.
Jasdeep Kaur Dhanoa, Ramneek Verma, R. S. Sethi, Jaspreet Singh Arora, C. S. Mukhopadhyay   +4 more
doaj   +1 more source