MicroRNA isomiRs reveal novel pathways linked to disease activity and fibrosis in MASLD [PDF]
Clinical and Molecular HepatologyBackground/Aims MicroRNA (miRNA) isoforms (isomiRs) broaden the regulatory landscape of canonical miRNAs, but their role in metabolic dysfunction-associated steatotic liver disease (MASLD) remains unknown.
Christian Brion +14 more
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Dynamic shifts in isomiR profiles during parasite maturation of Fasciola hepatica [PDF]
RNA BiologyWe investigated the isomiR profiles of the parasitic worm Fasciola hepatica across three developmental stages: newly excysted juveniles (NEJ), juveniles (JUV), and adults.
Dayna Sais +8 more
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Integrative genetic and genomic networks identify microRNA associated with COPD and ILD [PDF]
Scientific Reports, 2023 Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are clinically and molecularly heterogeneous diseases. We utilized clustering and integrative network analyses to elucidate roles for microRNAs (miRNAs) and miRNA isoforms ...
Ana B. Pavel +17 more
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IsomiR stoichiometry changes as disease biomarkers [PDF]
Molecular Therapy: Nucleic AcidsDespite substantial research interest over the past decade, microRNAs (miRNAs) have not yet succeeded in reaching their potential as non-invasive diagnostic biomarkers.
Alexandra L. McAllan +3 more
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MicroRNAs and Cancer Racial Disparities [PDF]
WIREs RNA, Volume 16, Issue 5, September/October 2025.MicroRNAs and cancer racial disparities. Race/ethnicity‐specific regulation of microRNAs at multiple levels (epigenetics, copy number, single‐nucleotide polymorphisms, and circulating or exosome secretion) provides a genetic basis for cancer racial disparities. ABSTRACT Cancer remains one of the leading causes of death worldwide.
Dan Zhao, Yifei Wang
wiley +2 more sources
IsomiRome analysis reveals dysregulation of 5’ isomiRs during SARS-CoV-2 infection [PDF]
Computational and Structural Biotechnology JournalAnnotated canonical miRNAs (anomiRs) are critical regulators of COVID-19 pathogenesis. Their 5′ isomiR counterparts, which harbor a shifted 5’ end and an altered seed region relative to cognate anomiRs, represent an essential yet understudied component ...
Ming-Ju Amy Lyu +7 more
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Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression. [PDF]
PLoS GeneticsMicroRNAs (miRNAs) are essential regulators of gene expression, yet few comprehensive databases exist for miRNA expression in non-model species, limiting our ability to characterize their roles in gene regulation, development, and disease.
Jonah N Cullen +34 more
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A Comprehensive Analysis of miRNA/isomiR Expression with Gender Difference. [PDF]
PLoS ONE, 2016 Although microRNAs (miRNAs) have been widely studied as epigenetic regulation molecules, fewer studies focus on the gender difference at the miRNA and isomiR expression levels.
Li Guo +3 more
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A comprehensive survey of miRNA repertoire and 3' addition events in the placentas of patients with pre-eclampsia from high-throughput sequencing. [PDF]
PLoS ONE, 2011 BackgroundTo gain insight into potential roles of isomiR spectrum and isomiRs with 3' additions in pre-eclampsia, we performed a comprehensive survey of miRNA repertoire and 3' addition events from placental samples with different degrees of pre ...
Li Guo +7 more
doaj +1 more source
Scientific Reports, 2022 MicroRNAs (miRNAs) are non-coding small RNAs which play a critical role in the regulation of gene expression in cells. It is known that miRNAs are often expressed as multiple isoforms, called isomiRs, which may have alternative regulatory functions ...
Christopher Michael Smith +1 more
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