Results 31 to 40 of about 1,011 (123)
RNA Biology, 2022 microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through translational repression and mRNA destabilization. During canonical miRNA biogenesis, several miRNA isoforms, or isomiRs, are produced from a single precursor miRNA ...
Ganesh Panzade +4 more
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Plant IsomiR Atlas: Large Scale Detection, Profiling, and Target Repertoire of IsomiRs in Plants
Frontiers in Plant Science, 2019 microRNAs (miRNAs) play an important role as key regulators controlling the post-transcriptional events in plants across development, abiotic and biotic stress, tissue polarity and also in defining the evolutionary basis of the origin of the post ...
Kun Yang +4 more
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BMC Bioinformatics, 2017 Background MicroRNAs carry out post-transcriptional gene regulation in animals by binding to the 3' untranslated regions of mRNAs, causing their degradation or translational repression. MicroRNAs influence many biological functions, and dysregulation can
Daniel Amsel +2 more
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Flexible pri-miRNA structures enable tunable production of 5’ isomiRs
RNA Biology, 2022 The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros +6 more
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Tumor classification and biomarker discovery based on the 5’isomiR expression level
BMC Cancer, 2019 Background The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation.
Shengqin Wang +3 more
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Andrology, EarlyView.ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu +8 more
wiley +1 more source
Concordant and discordant regulation of target genes by miR-31 and its isoforms. [PDF]
PLoS ONE, 2013 It has been shown that imprecise cleavage of a primary or precursor RNA by Drosha or Dicer, respectively, may yield a group of microRNA (miRNA) variants designated as "isomiR".
Yu-Tzu Chan +6 more
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Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
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Acta Physiologica, Volume 242, Issue 9, September 2026.ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson +3 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2020 Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns.
Tingming Liang, Leng Han, Li Guo
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