Results 51 to 60 of about 1,011 (123)

Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis

Cell Death and Disease, 2021
Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades.
Emi Dika, Elisabetta Broseghini, Elisa Porcellini, Martina Lambertini, Mattia Riefolo, Giorgio Durante, Phillipe Loher, Roberta Roncarati, Cristian Bassi, Cosimo Misciali, Massimo Negrini, Isidore Rigoutsos, Eric Londin, Annalisa Patrizi, Manuela Ferracin   +14 more
doaj   +1 more source

Population variation in miRNAs and isomiRs and their impact on human immunity to infection

Genome Biology, 2020
Background MicroRNAs (miRNAs) are key regulators of the immune system, yet their variation and contribution to intra- and inter-population differences in immune responses is poorly characterized.
Maxime Rotival, Katherine J. Siddle, Martin Silvert, Julien Pothlichet, Hélène Quach, Lluis Quintana-Murci   +5 more
doaj   +1 more source

How error correction affects polymerase chain reaction deduplication: A survey based on unique molecular identifier datasets of short reads

Quantitative Biology, Volume 13, Issue 3, September 2025.
Abstract Next‐generation sequencing data are widely utilised for various downstream applications in bioinformatics and numerous techniques have been developed for PCR‐deduplication and error‐correction to eliminate bias and errors introduced during the sequencing.
Pengyao Ping, Tian Lan, Shuquan Su, Wei Liu, Jinyan Li   +4 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, Volume 599, Issue 13, Page 1821-1851, July 2025.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Distinctive profile of IsomiR expression and novel microRNAs in rat heart left ventricle.

PLoS ONE, 2013
MicroRNAs (miRNAs) are single-stranded non-coding RNAs that negatively regulate target gene expression through mRNA cleavage or translational repression. There is mounting evidence that they play critical roles in heart disease.
Mary K McGahon, Janet M Yarham, Aideen Daly, Jasenka Guduric-Fuchs, Lyndsey J Ferguson, David A Simpson, Anthony Collins   +6 more
doaj   +1 more source

Examining the Role of Matrix Metalloproteinase‐2 and MicroRNAs Regulation in Breast Cancer

The Breast Journal, Volume 2025, Issue 1, 2025.
Matrix metalloproteinase (MMPs) is a class of zinc‐dependent enzymes that play an important role in the invasion and metastasis of cancer cells and have different types. MMP‐2 is one of the important enzymes of this family. MicroRNAs (miRNAs) are noncoding RNAs that are involved in the regulation of gene expression of many enzymes and factors in the ...
Elmira Aboutalebi Vand Beilankouhi, Niloufar Kheradi, Yosra Vaez-Gharamaleki, Salomeh Roshani, Sana Abbasi, Reza Safaralizadeh, Mohammad Valilo, Guan-Jun Yang   +7 more
wiley   +1 more source

Beta cell 5'-shifted isomiRs are candidate regulatory hubs in type 2 diabetes. [PDF]

PLoS ONE, 2013
Next-generation deep sequencing of small RNAs has unveiled the complexity of the microRNA (miRNA) transcriptome, which is in large part due to the diversity of miRNA sequence variants ("isomiRs").
Jeanette Baran-Gale, Emily E Fannin, C Lisa Kurtz, Praveen Sethupathy   +3 more
doaj   +1 more source

Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study

Epilepsia, Volume 65, Issue 11, Page 3406-3420, November 2024.
Abstract Objective Structural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary prevention. However, development of preventive treatments has been challenged by a lack of biomarkers for identifying the subset of individuals with the highest risk of epilepsy after the ...
Erwin A. van Vliet, Mirte Scheper, James D. Mills, Noora Puhakka, Kinga Szydlowska, Manuela Ferracin, Francesca Lovisari, Marie Soukupova, Silvia Zucchini, Prashant K. Srivastava, Michael R. Johnson, Katarzyna Lukasiuk, Jan A. Gorter, Eleonora Aronica, Asla Pitkänen, Michele Simonato   +15 more
wiley   +1 more source

Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods

BMC Genomics, 2019
Background RNA sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging.
Carrie Wright, Anandita Rajpurohit, Emily E. Burke, Courtney Williams, Leonardo Collado-Torres, Martha Kimos, Nicholas J. Brandon, Alan J. Cross, Andrew E. Jaffe, Daniel R. Weinberger, Joo Heon Shin   +10 more
doaj   +1 more source

A comprehensive overview of bull sperm-borne small non-coding RNAs and their diversity across breeds

Epigenetics & Chromatin, 2020
Background Mature sperm carry thousands of RNAs, including mRNAs, lncRNAs, tRNAs, rRNAs and sncRNAs, though their functional significance is still a matter of debate. Growing evidence suggests that sperm RNAs, especially sncRNAs, are selectively retained
Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Jean-Philippe Perrier, Sébastien Fritz, Chrystelle Le Danvic, Mekki Boussaha, Hélène Kiefer, Hélène Jammes, Laurent Schibler   +11 more
doaj   +1 more source