Results 1 to 10 of about 468,820 (359)
miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer
Genes, 2023 MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to messenger RNAs. miRNAs are important regulators of gene expression, and their dysregulation is implicated in many human ...
Bruce F Smith, Payal Agarwal
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Adipose-derived circulating miRNAs regulate gene expression in other tissues
Nature, 2017 Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Here we show that mice with an adipose-tissue-specific knockout of the microRNA (miRNA)-processing enzyme Dicer (ADicerKO),
Thomas Thomou +2 more
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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Nature Communications, 2013 Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to ...
Cristina Gutiérrez-Vázquez +1 more
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Journal of Extracellular Vesicles, 2019 Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients’ survival rate and quality of life. Although the potential role for small extracellular vesicles (sEVs) in early detection of many diseases has been ...
Li Min, Shengtao Zhu, Zheng Zhang
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An integrated expression atlas of miRNAs and their promoters in human and mouse
Nature Biotechnology, 2017 MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs and their promoters ...
Imad Abugessaisa +2 more
exaly +2 more sources
Functional Roles of lncRNAs in Recurrent Pregnancy Loss: A Review Study [PDF]
International Journal of Fertility and Sterility, 2023 Recurrent pregnancy loss (RPL) or recurrent miscarriage is the failure of pregnancy before 20-24 weeks that influencesaround 2-5% of couples. Several genetic, immunological, environmental and physical factors may influenceRPL.
Shirin Azizidoost +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 The adult neurogenic niches are complex multicellular systems, receiving regulatory input from a multitude of intracellular, juxtacrine, and paracrine signals and biological pathways. Within the niches, adult neural stem cells (aNSCs) generate astrocytic
Amber Penning +7 more
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Frontiers in Bioscience-Landmark, 2023 The endothelium, an essential component of the vascular system, plays a critical role in the inflammatory response. Under pro-inflammatory stimuli, endothelial cells undergo activation and dysfunction, leading to the release of inflammatory mediators and
Nadia Calabriso +5 more
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miRNAs in Cancer (Review of Literature)
International Journal of Molecular Sciences, 2022 MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs.
B. Smolarz +4 more
semanticscholar +1 more source
The role of Exosomal miRNAs in cancer
Journal of Translational Medicine, 2022 Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2018). Exosomal miRNAs modulate processes that
Chuanyun Li +8 more
semanticscholar +1 more source