Results 41 to 50 of about 365,273 (304)

The Activation of PI3K/AKT/mTOR Signaling Pathway in Response to Cabazitaxel Treatment in Metastatic Castration-Resistant Prostate Cancer Cells

open access: yesEuropean Journal of Biology, 2021
Objective: Despite advances in treatment approaches, metastatic castration-resistant prostate cancer (mCRPC) remains a clinical challenge to treat. Cabazitaxel (Cab), a third-line chemotherapy option for mCRPC, exhibits limited efficiency due to the ...
Işıl Ezgi Eryılmaz   +4 more
doaj   +1 more source

Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]

open access: yes, 2017
Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio   +3 more
core   +1 more source

Plasma Extracellular Vesicle miRNA Profiles Distinguish Chronic Obstructive Pulmonary Disease Exacerbations and Disease Severity

open access: yesInternational Journal of COPD, 2022
Hannah E O’Farrell, Rayleen V Bowman, Kwun M Fong, Ian A Yang Faculty of Medicine, the University of Queensland, Brisbane, QLD, AustraliaCorrespondence: Hannah E O’Farrell, Faculty of Medicine, the University of Queensland, Brisbane, QLD, Australia, Tel +
O'Farrell HE   +3 more
doaj  

Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. [PDF]

open access: yes, 2016
A comprehensive genomic and proteomic, computational, and physiological approach was employed to examine the (previously unexplored) role of microRNAs (miRNAs) as regulators of internal anal sphincter (IAS) smooth muscle contractile phenotype and basal ...
Addya, Sankar   +6 more
core   +3 more sources

Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty

open access: yesExperimental Gerontology, 2019
Frailty is a geriatric syndrome that leads not only to the loss of physical functions, but also to a generalized decline of the organism and a high risk of disability and dependency. Frailty's detection and management represent important goals for current gerontology.
Iryna, Rusanova   +7 more
openaire   +2 more sources

Comprehensive Analysis of a Competing Endogenous RNA Co-Expression Network in Chronic Obstructive Pulmonary Disease

open access: yesInternational Journal of COPD, 2023
Jingwei Wang,1,2,* Bowen Xia,3,* Ruimin Ma,1 Qiao Ye1,2 1Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Occupational Medicine and Toxicology ...
Wang J, Xia B, Ma R, Ye Q
doaj  

A Collection of Pre-mRNA Splicing Mutants in Arabidopsis thaliana

open access: yesG3: Genes, Genomes, Genetics, 2020
To investigate factors influencing pre-mRNA splicing in plants, we conducted a forward genetic screen using an alternatively-spliced GFP reporter gene in Arabidopsis thaliana.
Tatsuo Kanno   +7 more
doaj   +1 more source

miRVine: a microRNA expression atlas of grapevine based on small RNA sequencing [PDF]

open access: yes, 2015
We analyzed 70 small RNA libraries, prepared from berries, inflorescences, tendrils, buds, carpels, stamens and other samples at different developmental stages.
Belli Kullan, Jayakumar   +10 more
core   +3 more sources

Deficient Regulatory Innate Lymphoid Cells and Differential Expression of miRNAs in Acute Myeloid Leukemia Quantified by Next Generation Sequence

open access: yesCancer Management and Research, 2020
Jifeng Yu, Yingmei Li, Yue Pan, Yu Liu, Haizhou Xing, Xinsheng Xie, Dingming Wan, Zhongxing Jiang Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People’s Republic of ChinaCorrespondence: Jifeng Yu;
Yu J   +7 more
doaj  

A review on miRNAs as new biomarkers for colorectal cancer [PDF]

open access: yesJournal of Advanced Biomedical Sciences, 2019
Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important.
Kiyanoush Mohammadi, Reza Safaralizadeh
doaj  

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