Results 11 to 20 of about 365,273 (304)
Cancers, 2021 Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed +2 more
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Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions [PDF]
BioMed Research International, 2014 MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA
Guo, Li +4 more
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The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer [PDF]
Frontiers in Oncology, 2015 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and
Xin eQin +4 more
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Expression of miRNA-451 and miRNA-885 in Meningiomas
In Vivo, 2023 Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation.
Ozgur, Baran +12 more
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Mitochondrial Quality Control: the Role in Cardiac Injury
Frontiers in Bioscience-Landmark, 2022 The heart is a highly energy-dependent organ, and most of its energy is provided by mitochondrial oxidative phosphorylation. Therefore, maintaining a well-functioning mitochondrial population is of paramount importance for cardiac homeostasis, since ...
Grażyna Sygitowicz, Dariusz Sitkiewicz
doaj +1 more source
Serum micrornas as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma [PDF]
, 2016 The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and specific biomarkers, as is the early diagnosis of cholangiocarcinoma (CC), a complication of PSC.
Alpini, Gianfranco +17 more
core +2 more sources
Random walks on mutual microRNA-target gene interaction network improve the prediction of disease-associated microRNAs [PDF]
, 2017 Background: MicroRNAs (miRNAs) have been shown to play an important role in pathological initiation, progression and maintenance. Because identification in the laboratory of disease-related miRNAs is not straightforward, numerous network-based methods ...
Dinh-Toi Chu, Dinh-Toi Chu +4 more
core +2 more sources
Deciphering miRNAs’ Action through miRNA Editing [PDF]
International Journal of Molecular Sciences, 2019 MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. The outcome of a myriad of physiological processes and pathologies, including cancer, cardiovascular and metabolic diseases, relies ...
Correia De Sousa, Marta +4 more
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miRNA biomarkers in colon cancer liver metastasis: a preliminary analysis
结直肠肛门外科, 2022 [Objectives] To identify miRNAs associated with colon cancer liver metastasis and their influences on survival. [Methods] The study compared the miRNAs data sets of primary colon cancer tissues and liver metastasis tissues from colon cancer patients with
Fu Tianhao +8 more
doaj +1 more source
Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14 [PDF]
Animal Bioscience, 2023 Objective This study aims to evaluate the target genes of gga-miR-20a-5p and the regulated immune responses in the chicken macrophage cell line, HD11, by the exosome-mediated delivery of miR-20a-5p.
Yeojin Hong +5 more
doaj +1 more source