Results 41 to 50 of about 1,011 (123)

EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases

Biomedicines, 2022
MicroRNAs (miRNAs) are synthesized through a canonical pathway and play a role in human diseases, such as cancers and cardiovascular, neurodegenerative, psychiatric, and chronic inflammatory diseases.
Yasuko Arao, Mika Nakayama, Yoshiko Tsuji, Yumiko Hamano, Chihiro Otsuka, Andrea Vecchione, Ken Ofusa, Hideshi Ishii   +7 more
doaj   +1 more source

A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion. [PDF]

PLoS ONE, 2014
miRNAs are key regulatory small non-coding RNAs involved in critical steps of melanoma tumorigenesis; however, the relationship between sequence specific variations at the 5' or 3' termini (isomiR) of a miRNA and cancer phenotype remains unclear.
Sankhiros Babapoor, Elizabeth Fleming, Rong Wu, Soheil S Dadras   +3 more
doaj   +1 more source

isomiRs–Hidden Soldiers in the miRNA Regulatory Army, and How to Find Them?

Biomolecules, 2020
Numerous studies on microRNAs (miRNA) in cancer and other diseases have been accompanied by diverse computational approaches and experimental methods to predict and validate miRNA biological and clinical significance as easily accessible disease ...
Ilias Glogovitis, Galina Yahubyan, Thomas Würdinger, Danijela Koppers-Lalic, Vesselin Baev   +4 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

An isomiR expression panel based novel breast cancer classification approach using improved mutual information

BMC Medical Genomics, 2018
Background Gene expression-based profiling has been used to identify biomarkers for different breast cancer subtypes. However, this technique has many limitations.
Chaowang Lan, Hui Peng, Eileen M. McGowan, Gyorgy Hutvagner, Jinyan Li   +4 more
doaj   +1 more source

Extracellular Vesicle Properties and Functions Are Defined by the Originating Cell's Fitness Status

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Recent studies have focused on the role of dying cells in modulating immune function and shaping the local microenvironment. Apoptotic cells release various extracellular vesicles (EVs), such as exosomes and microvesicles, and form apoptotic bodies through membrane blebbing.
Stephanie Leyk, Imke Liebold, Clarissa Lanzloth, Ulricke Richardt, Johan M. Kux, Christoph Kilian, Manuela Moritz, Antonia Gocke, Simon Meyer, Katharina Höhn, Barbara Honecker, Helmut Haas, Marius Böttcher, Sören Weidemann, Simon Kind, Hartmut Schlüter, Nahla Galal Metwally, Lorenz Adlung, Pablo J. Sáez, Thomas Jacobs, Klaus Ruckdeschel, Lidia Bosurgi   +21 more
wiley   +1 more source

Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma

Computational and Structural Biotechnology Journal, 2021
Cholangiocarcinomas (CCAs) are tumors that arise from the cholangiocytes. Although some genes have been shown with important roles in pathological process, interactions or cross-talks among different RNAs are important to understand the detailed ...
Li Guo, Yuyang Dou, Yifei Yang, Shiqi Zhang, Yihao Kang, Lulu Shen, Lihua Tang, Yaodong Zhang, Changxian Li, Jun Wang, Tingming Liang, Xiangcheng Li   +11 more
doaj   +1 more source

Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection

Journal of Extracellular Biology, Volume 4, Issue 12, December 2025.
ABSTRACT Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune‐related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological ...
Humberto Doriguêtto Gravina, Ricardo Cardoso Castro, Ana Margarida Gonçalves, Julia Oliveira Lima, Fabrícia Heloísa Cavicchioli Sugiyama, Brenda Cavalin Moreira, Mateus da Silva Matias Antunes, Caroline Fontanari, Valdes Roberto Bollela, Yann Yves Lamarre, Fausto Almeida, Simone Kashima, Margarida Saraiva, Nuno Osório, Fabiani Gai Frantz   +14 more
wiley   +1 more source

A Review of IsomiRs in Colorectal Cancer

Non-Coding RNA, 2023
As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template ...
Molly A. Lausten, Bruce M. Boman
doaj   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, Volume 15, Issue 11, Page 1726-1737, November 2025.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source