Results 21 to 30 of about 1,011 (123)

An exploration of evolution, maturation, expression and function relationships in mir-23 ∼ 27 ∼ 24 cluster. [PDF]

PLoS ONE, 2014
The study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23 ∼ 27 ∼ 24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene ...
Tingming Liang, JiaFeng Yu, Chang Liu, Li Guo   +3 more
doaj   +1 more source

Skeletal muscle‐enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer‐independent manner

The FEBS Journal, Volume 290, Issue 24, Page 5692-5703, December 2023., 2023
MicroRNAs (miRNAs) are small noncoding RNAs that control essential cellular processes. For several decades, the molecular mechanisms underlying the functions and biogenesis of miRNAs have been clarified, whereas the molecular dynamics of miRNAs remain poorly understood.
Satoshi Oikawa, Shuaibang Yuan, Yoshio Kato, Takayuki Akimoto   +3 more
wiley   +1 more source

MicroRNA 4407 modulates nodulation in soybean by repressing a root‐specific ISOPENTENYLTRANSFERASE (GmIPT3)

New Phytologist, Volume 240, Issue 3, Page 1034-1051, November 2023., 2023
Summary MicroRNAs (miRNAs) are important regulators of plant biological processes, including soybean nodulation. One miRNA, miR4407, was identified in soybean roots and nodules. However, the function of miR4407 in soybean is still unknown. MiR4407, unique to soybean, positively regulates lateral root emergence and root structures and represses a root ...
Kejing Fan, Zhili Wang, Ching‐Ching Sze, Yongchao Niu, Fuk‐Ling Wong, Man‐Wah Li, Hon‐Ming Lam   +6 more
wiley   +1 more source

A deep learning method for miRNA/isomiR target detection

Scientific Reports, 2022
Accurate identification of microRNA (miRNA) targets at base-pair resolution has been an open problem for over a decade. The recent discovery of miRNA isoforms (isomiRs) adds more complexity to this problem.
Amlan Talukder, Wencai Zhang, Xiaoman Li, Haiyan Hu   +3 more
doaj   +1 more source

Entropy-based model for miRNA isoform analysis. [PDF]

PLoS ONE, 2015
MiRNAs have been widely studied due to their important post-transcriptional regulatory roles in gene expression. Many reports have demonstrated the evidence of miRNA isoform products (isomiRs) in high-throughput small RNA sequencing data.
Shengqin Wang, Jing Tu, Lei Wang, Zuhong Lu   +3 more
doaj   +1 more source

MicroRNA Isoforms Contribution to Melanoma Pathogenesis

Non-Coding RNA, 2021
Cutaneous melanoma (CM) is the most lethal tumor among skin cancers, and its incidence is constantly increasing. A deeper understanding of the molecular processes guiding melanoma pathogenesis could improve diagnosis, treatment and prognosis.
Elisabetta Broseghini, Emi Dika, Eric Londin, Manuela Ferracin   +3 more
doaj   +1 more source

A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy.

PLoS ONE, 2022
Hydrosalpinx is a chronic inflammatory condition with high recurrence rate, and it is reported among female population having fallopian tubal factor infertility.
Zhengyi Cao, Bo Xu, Yan Wu, Kang Luan, Xin Du   +4 more
doaj   +1 more source

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Scientific Reports, 2020
Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct
Angelica Giuliani, Eric Londin, Manuela Ferracin, Emanuela Mensà, Francesco Prattichizzo, Deborah Ramini, Fiorella Marcheselli, Rina Recchioni, Maria Rita Rippo, Massimiliano Bonafè, Isidore Rigoutsos, Fabiola Olivieri, Jacopo Sabbatinelli   +12 more
doaj   +1 more source

Paired-end small RNA sequencing reveals a possible overestimation in the isomiR sequence repertoire previously reported from conventional single read data analysis

BMC Bioinformatics, 2021
Background Next generation sequencing has allowed the discovery of miRNA isoforms, termed isomiRs. Some isomiRs are derived from imprecise processing of pre-miRNA precursors, leading to length variants.
Jose Francisco Sanchez Herrero, Raquel Pluvinet, Antonio Luna de Haro, Lauro Sumoy   +3 more
doaj   +1 more source

Integrated Analysis of Large-Scale Omics Data Revealed Relationship Between Tissue Specificity and Evolutionary Dynamics of Small RNAs in Maize (Zea mays)

Frontiers in Genetics, 2020
The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood.
Yu Xu, Ting Zhang, Ting Zhang, Yuchen Li, Zhenyan Miao, Zhenyan Miao   +5 more
doaj   +1 more source