Targetome profile of hsa-miR-93-5p is resistant to isoform formation in prostate adenocarcinoma [PDF]
PeerJMicroRNAs (miRNAs) and their isoforms, known as isomiRs, are important regulators of tumorigenesis that act as post-transcriptional modulators of gene expression.
Anton Zhiyanov +4 more
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MicroRNA isomiRs reveal novel pathways linked to disease activity and fibrosis in MASLD [PDF]
Clinical and Molecular HepatologyBackground/Aims MicroRNA (miRNA) isoforms (isomiRs) broaden the regulatory landscape of canonical miRNAs, but their role in metabolic dysfunction-associated steatotic liver disease (MASLD) remains unknown.
Christian Brion +14 more
doaj +2 more sources
New characteristics of MiRNA and IsomiR interactions with mRNA [PDF]
Scientific ReportsStudying the interactions between microRNAs/isomiRs and mRNAs is crucial due to their fundamental roles in gene regulation and disease. Although many isomiRs have been identified, the analysis of their interactions with mRNAs remains in its early stages.
Matthew Weston +3 more
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IsomiRome analysis reveals dysregulation of 5’ isomiRs during SARS-CoV-2 infection [PDF]
Computational and Structural Biotechnology JournalAnnotated canonical miRNAs (anomiRs) are critical regulators of COVID-19 pathogenesis. Their 5′ isomiR counterparts, which harbor a shifted 5’ end and an altered seed region relative to cognate anomiRs, represent an essential yet understudied component ...
Ming-Ju Amy Lyu +7 more
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MicroRNAs and Cancer Racial Disparities [PDF]
WIREs RNA, Volume 16, Issue 5, September/October 2025.MicroRNAs and cancer racial disparities. Race/ethnicity‐specific regulation of microRNAs at multiple levels (epigenetics, copy number, single‐nucleotide polymorphisms, and circulating or exosome secretion) provides a genetic basis for cancer racial disparities. ABSTRACT Cancer remains one of the leading causes of death worldwide.
Dan Zhao, Yifei Wang
wiley +2 more sources
Examining the Role of Matrix Metalloproteinase‐2 and MicroRNAs Regulation in Breast Cancer [PDF]
The Breast Journal, Volume 2025, Issue 1, 2025.Matrix metalloproteinase (MMPs) is a class of zinc‐dependent enzymes that play an important role in the invasion and metastasis of cancer cells and have different types. MMP‐2 is one of the important enzymes of this family. MicroRNAs (miRNAs) are noncoding RNAs that are involved in the regulation of gene expression of many enzymes and factors in the ...
Elmira Aboutalebi Vand Beilankouhi +7 more
wiley +2 more sources
Dynamic shifts in isomiR profiles during parasite maturation of Fasciola hepatica [PDF]
RNA BiologyWe investigated the isomiR profiles of the parasitic worm Fasciola hepatica across three developmental stages: newly excysted juveniles (NEJ), juveniles (JUV), and adults.
Dayna Sais +8 more
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IsomiR stoichiometry changes as disease biomarkers [PDF]
Molecular Therapy: Nucleic AcidsDespite substantial research interest over the past decade, microRNAs (miRNAs) have not yet succeeded in reaching their potential as non-invasive diagnostic biomarkers.
Alexandra L. McAllan +3 more
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Combinatorial Analysis of miRNAs and tRNA Fragments as Potential Biomarkers for Cancer Patients in Liquid Biopsies [PDF]
Non-Coding RNABackground: Liquid biopsy has gained significant attention as a non-invasive method for cancer detection and monitoring. IsomiRs and tRNA-derived fragments (tRFs) are small non-coding RNAs that arise from non-canonical microRNA (miRNAs) processing and ...
Ilias Glogovitis +7 more
doaj +2 more sources
The subcellular distribution of miRNA isoforms, tRNA-derived fragments, and rRNA-derived fragments depends on nucleotide sequence and cell type [PDF]
BMC BiologyBackground MicroRNA isoforms (isomiRs), tRNA-derived fragments (tRFs), and rRNA-derived fragments (rRFs) represent most of the small non-coding RNAs (sncRNAs) found in cells.
Tess Cherlin +11 more
doaj +2 more sources