Results 31 to 40 of about 1,529 (123)

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells, 2019
Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast, Paul H.A. Quax, A. Yaël Nossent   +2 more
doaj   +1 more source

IsomiR_Window: a system for analyzing small-RNA-seq data in an integrative and user-friendly manner

BMC Bioinformatics, 2021
Background IsomiRs are miRNA variants that vary in length and/or sequence when compared to their canonical forms. These variants display differences in length and/or sequence, including additions or deletions of one or more nucleotides (nts) at the 5 ...
Ana M. Vasconcelos, Maria Beatriz Carmo, Beatriz Ferreira, Inês Viegas, Margarida Gama-Carvalho, António Ferreira, Andreia J. Amaral   +6 more
doaj   +1 more source

A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia

BMC Genomics, 2018
Background MicroRNA (miRNA) profiling is an important step in studying biological associations and identifying marker candidates. miRNA exists in isoforms, called isomiRs, which may exhibit distinct properties.
Chung Wah Wu, Jared M. Evans, Shengbing Huang, Douglas W. Mahoney, Brian A. Dukek, William R. Taylor, Tracy C. Yab, Thomas C. Smyrk, Jin Jen, John B. Kisiel, David A. Ahlquist   +10 more
doaj   +1 more source

5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

Journal of Experimental & Clinical Cancer Research, 2022
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner   +19 more
doaj   +1 more source

Research Note: IsomiRs of chicken miR-146b-5p are activated upon Salmonella enterica serovar Enteritidis infection

Poultry Science, 2022
: In order to enrich the knowledge of chicken transcriptomic response to Salmonella enterica serovar Enteritidis infection, 2-day-old chicks were orally inoculated with this bacteria (1.0 × 108 cfu/mL), and then the cecum tissues of 3 days post ...
Geng Hu, Liying Liu, Xiuxiu Miao, Yanan Zhao, Xianyao Li   +4 more
doaj   +1 more source

MicroRNA biogenesis and variability

Biomolecular Concepts, 2013
MicroRNAs (miRNAs) are cell-endogenous small noncoding RNAs that, through RNA interference, are involved in the posttranscriptional regulation of mRNAs.
García-López Jesús, Brieño-Enríquez Miguel A., del Mazo Jesús   +2 more
doaj   +1 more source

Coupling miR/isomiR and mRNA Expression Signatures Unveils New Molecular Layers of Endometrial Receptivity

Life, 2021
Embryo implantation depends on endometrial receptivity (ER). To achieve ER, the preparation of the uterine lining requires controlled priming by ovarian hormones and the expression of numerous genes in the endometrial tissue.
Maria Nikolova, Mladen Naydenov, Ilias Glogovitis, Apostol Apostolov, Merli Saare, Nageswara Boggavarapu, Andres Salumets, Vesselin Baev, Galina Yahubyan   +8 more
doaj   +1 more source

A comparative analysis of single cell small RNA sequencing data reveals heterogeneous isomiR expression and regulation

Scientific Reports, 2022
MicroRNAs (miRNAs) are non-coding small RNAs which play a critical role in the regulation of gene expression in cells. It is known that miRNAs are often expressed as multiple isoforms, called isomiRs, which may have alternative regulatory functions ...
Christopher Michael Smith, Gyorgy Hutvagner   +1 more
doaj   +1 more source

Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma.

PLoS ONE, 2020
BACKGROUND:MicroRNA (miR)s are promising diagnostic biomarkers of cancer. Recent next generation sequencer (NGS) studies have found that isoforms of micro RNA (isomiR) circulate in the bloodstream similarly to mature micro RNA (miR). We hypothesized that
Yuta Ibuki, Yukie Nishiyama, Yasuhiro Tsutani, Manabu Emi, Yoichi Hamai, Morihito Okada, Hidetoshi Tahara   +6 more
doaj   +1 more source

An isomiR expression panel based novel breast cancer classification approach using improved mutual information

BMC Medical Genomics, 2018
Background Gene expression-based profiling has been used to identify biomarkers for different breast cancer subtypes. However, this technique has many limitations.
Chaowang Lan, Hui Peng, Eileen M. McGowan, Gyorgy Hutvagner, Jinyan Li   +4 more
doaj   +1 more source