Results 41 to 50 of about 1,529 (123)

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Comparative miRomics of Salt-Tolerant and Salt-Sensitive Rice

Journal of Integrative Bioinformatics, 2017
Increase in soil salt causes osmotic and ionic stress to plants, which inhibits their growth and productivity. Rice production is also hampered by salinity and the effect of salt is most severe at the seedling and reproductive stages. Salainity tolerance
Goswami Kavita, Tripathi Anita, Sanan-Mishra Neeti   +2 more
doaj   +1 more source

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk. [PDF]

PLoS ONE, 2018
Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases.
Mercedes Rubio, Mariona Bustamante, Carles Hernandez-Ferrer, Dietmar Fernandez-Orth, Lorena Pantano, Yaris Sarria, Maria Piqué-Borras, Kilian Vellve, Silvia Agramunt, Ramon Carreras, Xavier Estivill, Juan R Gonzalez, Alfredo Mayor   +12 more
doaj   +1 more source

A deep learning method for miRNA/isomiR target detection

Scientific Reports, 2022
Accurate identification of microRNA (miRNA) targets at base-pair resolution has been an open problem for over a decade. The recent discovery of miRNA isoforms (isomiRs) adds more complexity to this problem.
Amlan Talukder, Wencai Zhang, Xiaoman Li, Haiyan Hu   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Extracellular Vesicle Properties and Functions Are Defined by the Originating Cell's Fitness Status

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Recent studies have focused on the role of dying cells in modulating immune function and shaping the local microenvironment. Apoptotic cells release various extracellular vesicles (EVs), such as exosomes and microvesicles, and form apoptotic bodies through membrane blebbing.
Stephanie Leyk, Imke Liebold, Clarissa Lanzloth, Ulricke Richardt, Johan M. Kux, Christoph Kilian, Manuela Moritz, Antonia Gocke, Simon Meyer, Katharina Höhn, Barbara Honecker, Helmut Haas, Marius Böttcher, Sören Weidemann, Simon Kind, Hartmut Schlüter, Nahla Galal Metwally, Lorenz Adlung, Pablo J. Sáez, Thomas Jacobs, Klaus Ruckdeschel, Lidia Bosurgi   +21 more
wiley   +1 more source

Hi-fidelity discrimination of isomiRs using G-quadruplex gatekeepers. [PDF]

PLoS ONE, 2017
Core microRNA (miRNA) sequences exist as populations of variants called isomiRs made up of different lengths and nucleotide compositions. In particular, the short sequences of miRNA make single-base isomiR mismatches very difficult to be discriminated ...
Nianjia Seow, Renzo A Fenati, Ashley R Connolly, Amanda V Ellis   +3 more
doaj   +1 more source

A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy.

PLoS ONE, 2022
Hydrosalpinx is a chronic inflammatory condition with high recurrence rate, and it is reported among female population having fallopian tubal factor infertility.
Zhengyi Cao, Bo Xu, Yan Wu, Kang Luan, Xin Du   +4 more
doaj   +1 more source

Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection

Journal of Extracellular Biology, Volume 4, Issue 12, December 2025.
ABSTRACT Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune‐related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological ...
Humberto Doriguêtto Gravina, Ricardo Cardoso Castro, Ana Margarida Gonçalves, Julia Oliveira Lima, Fabrícia Heloísa Cavicchioli Sugiyama, Brenda Cavalin Moreira, Mateus da Silva Matias Antunes, Caroline Fontanari, Valdes Roberto Bollela, Yann Yves Lamarre, Fausto Almeida, Simone Kashima, Margarida Saraiva, Nuno Osório, Fabiani Gai Frantz   +14 more
wiley   +1 more source