Results 31 to 40 of about 31,514 (218)

microRNA biogenesis and senescence

Aging, 2013
Peer ...
Gómez-Cabello, Daniel, Adrados, Isabel, Palmero, Ignacio   +2 more
openaire   +3 more sources

MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review

Frontiers in Molecular Neuroscience, 2013
The 22q11.2 deletion is the strongest known genetic risk factor for schizophrenia. Research has implicated microRNA-mediated dysregulation in 22q11.2 deletion syndrome (22q11.2DS) schizophrenia risk.
Andreas J. eForstner, Andreas J. eForstner, Franziska eDegenhardt, Franziska eDegenhardt, Gerhard eSchratt, Markus M. eNöthen, Markus M. eNöthen   +6 more
doaj   +1 more source

Hormonal Regulation of MicroRNA Biogenesis [PDF]

Molecular Cell, 2009
In this issue of Molecular Cell, Yamagata et al. (2009) provide insight into the complex posttranscriptional regulation of miRNA biogenesis by showing that the processing of a subset of miRNAs is inhibited by the estrogen receptor.
Macias, Sara, Michlewski, Gracjan, Cáceres, Javier F.   +2 more
openaire   +2 more sources

Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma [PDF]

PeerJ
Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress
Elena N. Voropaeva, Yuriy L. Orlov, Anastasia B. Loginova, Olga B. Seregina, Vladimir N. Maksimov, Tatiana I. Pospelova   +5 more
doaj   +2 more sources

MicroRNA-directed siRNA biogenesis in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2010
RNA interference (RNAi) is a post-transcriptional silencing process, triggered by double-stranded RNA (dsRNA), leading to the destabilization of homologous mRNAs. A distinction has been made between endogenous RNAi-related pathways and the exogenous RNAi
Régis L Corrêa, Florian A Steiner, Eugene Berezikov, René F Ketting   +3 more
doaj   +1 more source

The miR-17 ∼ 92a cluster of microRNAs is required for the fitness of Foxp3+ regulatory T cells. [PDF]

PLoS ONE, 2014
By genetic inactivation of key microRNA biogenesis enzymes, we and others have previously demonstrated the critical requirement of the microRNA pathway for the differentiation and function of Foxp3(+) regulatory T cells.
Jarrod P J Skinner, Ashleigh A Keown, Mark M W Chong   +2 more
doaj   +1 more source

Efficiency and specificity in microRNA biogenesis [PDF]

Nature Structural & Molecular Biology, 2012
Primary microRNA cleavage by the Drosha-Dgcr8 'Microprocessor' complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues.
Barad, Omer, Mann, Mati, Chapnik, Elik, Shenoy, Archana, Blelloch, Robert, Barkai, Naama, Hornstein, Eran   +6 more
openaire   +2 more sources

MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi

BMC Genomics, 2012
Background MicroRNAs play a vital role in the regulation of gene expression and have been identified in every animal with a sequenced genome examined thus far, except for the placozoan Trichoplax. The genomic repertoires of metazoan microRNAs have become
Maxwell Evan K, Ryan Joseph F, Schnitzler Christine E, Browne William E, Baxevanis Andreas D   +4 more
doaj   +1 more source

microPrimer: the biogenesis and function of microRNA [PDF]

Development, 2005
Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes.
Du, Tingting, Zamore, Phillip D.
openaire   +3 more sources

MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes. [PDF]

PLoS ONE, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that affect the post-transcriptional regulation of various biological pathways. To date, it is not fully understood how miRNAs regulate mitochondrial biogenesis.
Linyuan Shen, Lei Chen, Shunhua Zhang, Jingjing Du, Lin Bai, Yi Zhang, Yanzhi Jiang, Xuewei Li, Jinyong Wang, Li Zhu   +9 more
doaj   +1 more source