Results 31 to 40 of about 31,660 (233)
Cepred: predicting the co-expression patterns of the human intronic microRNAs with their host genes. [PDF]
PLoS ONE, 2009 Identifying the tissues in which a microRNA is expressed could enhance the understanding of the functions, the biological processes, and the diseases associated with that microRNA.
Dong Wang +5 more
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MicroRNA biogenesis and cellular proliferation [PDF]
Translational Research, 2015 Given the fundamental roles of microRNAs (miRNAs) in physiological, developmental, and pathologic processes, we hypothesized that genes involved in miRNA biogenesis contribute to human complex traits. For 13 such genes, we evaluated the relationship between transcription and 2 classes of complex traits, namely cellular growth and sensitivity to various
Divya, Lenkala +4 more
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microRNA biogenesis and senescence
Aging, 2013 Peer ...
Gómez-Cabello, Daniel +2 more
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MicroRNA biogenesis pathways in cancer [PDF]
Nature Reviews Cancer, 2015 MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of
Shuibin, Lin, Richard I, Gregory
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Frontiers in Molecular Neuroscience, 2013 The 22q11.2 deletion is the strongest known genetic risk factor for schizophrenia. Research has implicated microRNA-mediated dysregulation in 22q11.2 deletion syndrome (22q11.2DS) schizophrenia risk.
Andreas J. eForstner +6 more
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Hormonal Regulation of MicroRNA Biogenesis [PDF]
Molecular Cell, 2009 In this issue of Molecular Cell, Yamagata et al. (2009) provide insight into the complex posttranscriptional regulation of miRNA biogenesis by showing that the processing of a subset of miRNAs is inhibited by the estrogen receptor.
Macias, Sara +2 more
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Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma [PDF]
PeerJHere, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress
Elena N. Voropaeva +5 more
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MicroRNA-directed siRNA biogenesis in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2010 RNA interference (RNAi) is a post-transcriptional silencing process, triggered by double-stranded RNA (dsRNA), leading to the destabilization of homologous mRNAs. A distinction has been made between endogenous RNAi-related pathways and the exogenous RNAi
Régis L Corrêa +3 more
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The miR-17 ∼ 92a cluster of microRNAs is required for the fitness of Foxp3+ regulatory T cells. [PDF]
PLoS ONE, 2014 By genetic inactivation of key microRNA biogenesis enzymes, we and others have previously demonstrated the critical requirement of the microRNA pathway for the differentiation and function of Foxp3(+) regulatory T cells.
Jarrod P J Skinner +2 more
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Efficiency and specificity in microRNA biogenesis [PDF]
Nature Structural & Molecular Biology, 2012 Primary microRNA cleavage by the Drosha-Dgcr8 'Microprocessor' complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues.
Barad, Omer +6 more
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