Results 1 to 10 of about 2,736,514 (278)
Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation. [PDF]
PLoS ONE, 2015 Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic
Frederique Zindy +7 more
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eLife, 2020 Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to ...
Januka S Athukoralage +5 more
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Transcriptional control of an essential ribozyme in Drosophila reveals an ancient evolutionary divide in animals. [PDF]
PLoS Genetics, 2015 Ribonuclease P (RNase P) is an essential enzyme required for 5'-maturation of tRNA. While an RNA-free, protein-based form of RNase P exists in eukaryotes, the ribonucleoprotein (RNP) form is found in all domains of life.
Sathiya N Manivannan +3 more
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Sinorhizobium meliloti RNase III: Catalytic Features and Impact on Symbiosis
Frontiers in Genetics, 2018 Members of the ribonuclease (RNase) III family of enzymes are metal-dependent double-strand specific endoribonucleases. They are ubiquitously found and eukaryotic RNase III-like enzymes include Dicer and Drosha, involved in RNA processing and RNA ...
Margarida Saramago +4 more
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Structural determinants of Arabidopsis thaliana Hyponastic leaves 1 function in vivo. [PDF]
PLoS ONE, 2014 MicroRNAs have turned out to be important regulators of gene expression. These molecules originate from longer transcripts that are processed by ribonuclease III (RNAse III) enzymes. Dicer proteins are essential RNAse III enzymes that are involved in the
Paula Burdisso +5 more
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DICER1 syndrome and thyroid disease
Journal of Pediatric Surgery Case Reports, 2016 DICER1, a member of the ribonuclease III (RNase III) family, is known to play an important role in the post-transcriptional regulation of gene expression and germline mutations have been associated with a familial tumor susceptibility syndrome.
Michael Canfarotta +4 more
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Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals. [PDF]
PLoS Genetics, 2015 Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and biochemical annotations of the signals required for
Jules Gagnon +4 more
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MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]
Open Biology, 2013 The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson +2 more
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Microorganisms, 2022 Carocin S2 is a bacteriocin with a low molecular weight generated by Pectobacterium carotovorum subsp. carotovorum 3F3 strain. The caroS2K gene, which is found in the genomic DNA alongside the caroS2I gene, which codes for an immunity protein, encodes ...
Ping-Chen Chung +6 more
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Poly(A)-Specific Ribonuclease Mediates 3′-End Trimming of Argonaute2-Cleaved Precursor MicroRNAs
Cell Reports, 2013 MicroRNAs (miRNAs) are typically generated as ∼22-nucleotide double-stranded RNAs via the processing of precursor hairpins by the ribonuclease III enzyme Dicer, after which they are loaded into Argonaute (Ago) proteins to form an RNA-induced silencing ...
Mayuko Yoda +6 more
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