Results 31 to 40 of about 2,736,514 (278)
International Journal of Endocrinology, 2020 As a type III ribonuclease (RNase III) specifically cleaving double-stranded RNA substrates into short fragments, Dicer is indispensable in a range of physi/pathologic processes, e.g., nutrient deprivation, hypoxia, or DNA damage.
Xiaohui Tong +3 more
doaj +1 more source
Noncatalytic assembly of ribonuclease III with double-stranded RNA. [PDF]
Structure, 2004 Ribonuclease III (RNase III) represents a family of double-stranded RNA (dsRNA) endonucleases. The simplest bacterial enzyme contains an endonuclease domain (endoND) and a dsRNA binding domain (dsRBD). RNase III can affect RNA structure and gene expression in either of two ways: as a dsRNA-processing enzyme that cleaves dsRNA, or as a dsRNA binding ...
J. Błaszczyk +5 more
semanticscholar +3 more sources
Cells, 2019 Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis.
Soo Jung Cho +6 more
doaj +1 more source
A stepwise model for double‐stranded RNA processing by ribonuclease III [PDF]
Molecular Microbiology, 2007 SummaryRNA interference is mediated by small interfering RNAs produced by members of the ribonuclease III (RNase III) family represented by bacterial RNase III and eukaryotic Rnt1p, Drosha and Dicer. For mechanistic studies, bacterial RNase III has been a valuable model system for the family.
J. Gan +5 more
semanticscholar +3 more sources
Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location
BMC Genomics, 2002 Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase III orthologue has been implicated in
Nicholson Rhonda H +2 more
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Ribonuclease III Processing of Coaxially Stacked RNA Helices [PDF]
Journal of Biological Chemistry, 1999 The RNase III family of endoribonucleases participates in maturation and decay of cellular and viral transcripts by processing of double-stranded RNA. RNase III degradation is inherent to most antisense RNA-regulated gene systems in Escherichia coli. In the hok/sok system from plasmid R1, Sok antisense RNA targets the hok mRNA for RNase III-mediated ...
Franch, T., Thisted, T., Gerdes, K.
openaire +4 more sources
The microRNA-processing enzyme Dicer is essential for thyroid function. [PDF]
PLoS ONE, 2011 Dicer is a type III ribonuclease required for the biogenesis of microRNAs (miRNAs), a class of small non-coding RNAs regulating gene expression at the post-transcriptional level.
Daniela Frezzetti +8 more
doaj +1 more source
PLoS Pathogens, 2022 The exogenous small interfering RNA (exo-siRNA) pathway is a key antiviral mechanism in the Aedes aegypti mosquito, a widely distributed vector of human-pathogenic arboviruses.
Rommel J Gestuveo +10 more
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Phylogenetic analysis of the endoribonuclease Dicer family. [PDF]
PLoS ONE, 2014 Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level.
Zeqian Gao +4 more
doaj +1 more source
Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence
bioRxiv, 2020 Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) second messengers in response to viral infection of bacteria and archaea, potentiating an immune response by binding and activating ancillary effector nucleases such as Csx1.
Aleksei Samolygo +3 more
semanticscholar +1 more source