Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation. [PDF]
Sci Rep, 2016 Ribonuclease III (RNase III) is a conserved, gene-regulatory bacterial endonuclease that cleaves double-helical structures in diverse coding and noncoding RNAs.
Gone S +3 more
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The production of extracellular proteins is regulated by ribonuclease III via two different pathways in Staphylococcus aureus. [PDF]
PLoS ONE, 2011 Staphylococcus aureus ribonuclease III belongs to the enzyme family known to degrade double-stranded RNAs. It has previously been reported that RNase III cannot influence cell growth but regulates virulence gene expression in S. aureus.
Yu Liu +8 more
doaj +3 more sources
Ribonuclease III mechanisms of double-stranded RNA cleavage. [PDF]
Wiley Interdiscip Rev RNA, 2014 Double‐stranded(ds) RNA has diverse roles in gene expression and regulation, host defense, and genome surveillance in bacterial and eukaryotic cells.
Nicholson AW.
europepmc +4 more sources
Combined computational and experimental analysis of a complex of ribonuclease III and the regulatory macrodomain protein, YmdB [PDF]
Proteins: Structure, Function and Bioinformatics, 2015 Ribonuclease III is a conserved bacterial endonuclease that cleaves double‐stranded(ds) structures in diverse coding and noncoding RNAs. RNase III is subject to multiple levels of control that in turn confer global post‐transcriptional regulation.
Mercedes Alfonso-Prieto +2 more
exaly +3 more sources
A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA. [PDF]
Nucleic Acids Res, 2021 Members of the ribonuclease III (RNase III) family regulate gene expression by processing double-stranded RNA (dsRNA). This family includes eukaryotic Dicer and Drosha enzymes that generate small dsRNAs in the RNA interference (RNAi) pathway.
Cánovas-Márquez JT +7 more
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The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate. [PDF]
Nucleic Acids Res, 2016 Members of the ribonuclease III (RNase III) family regulate gene expression by triggering the degradation of double stranded RNA (dsRNA). Hundreds of RNase III cleavage targets have been identified and their impact on RNA maturation and stability is now ...
Comeau MA, Lafontaine DA, Abou Elela S.
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The Functional Cycle of Rnt1p: Five Consecutive Steps of Double-Stranded RNA Processing by a Eukaryotic RNase III. [PDF]
Structure, 2017 SUMMARY Double-stranded RNA (dsRNA)-specific ribonuclease III (RNase III) proteins are required for RNA maturation and gene regulation. The mechanism of prokaryotic RNase IIIs has been well characterized, but how eukaryotic RNase IIIs (exemplified by ...
Song H +5 more
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Nature Communications, 2021 Type III CRISPR-Cas systems recognize and cleave target RNAs and produce signalling molecules. Here the authors discover that both processes are governed by a flexible seed region, ultimately resulting in SCOPE, a SARSCoV-2 diagnostic assay with atto ...
Jurre A. Steens +12 more
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Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system [PDF]
The EMBO JournalType III CRISPR systems generate cyclic oligoadenylate (cOA, 3 to 6 AMPs) messengers upon detecting viral RNA, activating downstream effectors to defend against viral infection.
Ruyi Shi +4 more
doaj +2 more sources
Characterization of Aquifex aeolicus ribonuclease III and the reactivity epitopes of its pre-ribosomal RNA substrates. [PDF]
Nucleic Acids Res, 2011 Ribonuclease III cleaves double-stranded (ds) structures in bacterial RNAs and participates in diverse RNA maturation and decay pathways. Essential insight on the RNase III mechanism of dsRNA cleavage has been provided by crystallographic studies of the ...
Shi Z +3 more
europepmc +2 more sources