Results 21 to 30 of about 16,723 (215)

Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology [PDF]

Cells, 2021
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders, which are characterized by accumulation of somatic mutations. The acquired mutation burden is suggested to define the pathway and consequent phenotype of the pathology.
Dmitrii S. Bug, Artem V. Tishkov, Ivan S. Moiseev, Yuri B. Porozov, Natalia V. Petukhova   +4 more
openaire   +3 more sources

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

RNA Biology, 2022
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu   +6 more
doaj   +1 more source

Drosha as an interferon-independent antiviral factor [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Virus infections must be combated at a cellular level. The strategies used to inhibit virus differ dramatically when comparing plants and insects to mammals. Here, we identify an evolutionary conserved antiviral response that is independent of these known defenses.
Jillian S, Shapiro, Sonja, Schmid, Lauren C, Aguado, Leah R, Sabin, Ari, Yasunaga, Jaehee V, Shim, David, Sachs, Sara, Cherry, Benjamin R, tenOever   +8 more
openaire   +2 more sources

Predicting Drosha and Dicer Cleavage Sites with DeepMirCut [PDF]

Frontiers in Molecular Biosciences, 2022
MicroRNAs are a class of small RNAs involved in post-transcriptional gene silencing with roles in disease and development. Many computational tools have been developed to identify novel microRNAs. However, there have been no attempts to predict cleavage sites for Drosha from primary sequence, or to identify cleavage sites using deep neural networks ...
Jimmy Bell, David A. Hendrix, David A. Hendrix   +2 more
openaire   +3 more sources

HIF1 and DROSHA are involved in MMACHC repression in hypoxia

Biochimica et Biophysica Acta (BBA) - General Subjects, 2022
The MMACHC gene encodes for an enzyme involved in intracellular vitamin B12 metabolism, and autosomal recessive defects in MMACHC represent the most common disorder of intracellular vitamin B12 metabolism. Recent studies have identified increased levels of reactive oxygen species in cells and tissues with MMACHC dysfunction, suggesting a role for ...
Kiessling, Eva, Peters, Florian, Ebner, Lynn J A, Merolla, Luca, Samardzija, Marijana, Baumgartner, Matthias R, Grimm, Christian, Froese, D Sean   +7 more
openaire   +3 more sources

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]

Open Biology, 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson, Andrew M. Lew, Mark M. W. Chong   +2 more
doaj   +1 more source

Methylation of DROSHA and DICER as a Biomarker for the Detection of Lung Cancer [PDF]

Cancers, 2021
Background: Lung cancer is the leading cause of cancer-related deaths. Early diagnosis may improve the prognosis. Methods: Using quantitative methylation-specific real-time PCR (qMSP-PCR), we assessed the methylation status of two genes (in two subsequent regions according to locations in their promoter sequences) related to carcinogenesis, DICER and ...
Michał Szczyrek, Anna Grenda, Barbara Kuźnar-Kamińska, Paweł Krawczyk, Marek Sawicki, Halina Batura-Gabryel, Radosław Mlak, Aneta Szudy-Szczyrek, Tomasz Krajka, Andrzej Krajka, Janusz Milanowski   +10 more
openaire   +2 more sources

The evidence for a microRNA product of human DROSHA gene [PDF]

RNA Biology, 2017
MicroRNAs are short RNA molecules that regulate function and stability of a large subset of eukaryotic mRNAs. In the main pathway of microRNA biogenesis, a short "hairpin" is excised from a primary transcript by ribonuclease DROSHA, followed by additional nucleolytic processing by DICER and inclusion of the mature microRNA into the RNA-induced ...
Peter, Mechtler, Sydney, Johnson, Hannah, Slabodkin, Amir B, Cohanim, Leonid, Brodsky, Eugene S, Kandel   +5 more
openaire   +2 more sources

Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway

Biomolecules, 2020
The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson
doaj   +1 more source

Genetic Variants of MicroRNA and DROSHA Genes in Association With the Risk of Tuberculosis in the Amazon Population

Frontiers in Genetics, 2022
Tuberculosis (TB) is a chronic infection caused by Mycobacterium tuberculosis (Mtb) with high incidence and mortality. Studies reported that host genetic variants might be associated with the risk of tuberculosis.
Diana Feio da Veiga Borges Leal, Mayara Natália Santana da Silva, Lucas Favacho Pastana, Marianne Rodrigues Fernandes, Aidalucy do Socorro Costa de Athayde, Débora Christina Ricardo Fernandes Porchera, Cleonardo Augusto da Silva, Antônio André Conde Modesto, Paulo Pimentel De Assumpcão, Sidney Emanuel Batista dos Santos, Sidney Emanuel Batista dos Santos, Ney Pereira Carneiro dos Santos   +11 more
doaj   +1 more source