Results 21 to 30 of about 17,302 (170)
Brazilian Journal of Medical and Biological Research, 2022 The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis.
I. Ormenezi +5 more
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Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Pre-eclampsia is a serious problem of pregnancy that is associated with proteinuria and increased blood pressure in the second half of pregnancy. It is one of the three leading causes of maternal and fetal mortality. Dysregulated expression
Roghayeh Dargahi +3 more
doaj +1 more source
Drosha Regulates Gene Expression Independently of RNA Cleavage Function
Cell Reports, 2013 Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically binds promoter-proximal ...
Natalia Gromak +6 more
doaj +1 more source
RNA Biology, 2022 The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both ...
Sudhaker Dharavath +2 more
doaj +1 more source
The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility
Clinical and Experimental Hypertension, 2018 Purpose: Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The aim of this study
Mahnaz Rezaei +6 more
doaj +1 more source
Drosha enhances exon 5 splicing.
, 2014 (A) Radiolabelled RT-PCR analysis of endogenous eIF4H splicing, and expression of Drosha, DGCR8, DICER and a loading control, GAPDH, in HEK-293T control cells or following transfection with Drosha, Dicer or TN Drosha. (B) Quantitation of exon 5 splicing.
Mallory A. Havens (558474) +2 more
core +1 more source
Structures of human Drosha and Giardia Dicer.
, 2019 Front view ribbon representation of the structure of (A) Drosha and (B) Dicer. The proteins are colored with similar colors for similar domains. Domains colors are as follow: N-terminal Platform domain (Drosha: cyan, Dicer: dark blue), putative PAZ-like ...
Rotem Aharoni (8108177) +1 more
core +1 more source
Acetylation and Ubiquitination regulate Drosha protein level.
, 2013 All experiments were repeated three times with similar results ...
Dennis Pantazatos (451804) +7 more
core +1 more source
DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs
Molecular Therapy: Nucleic Acids, 2018 RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNAmiR) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNAmiR-containing recombinant vectors and hypothesized that this could be due ...
Hee Ho Park +8 more
doaj +1 more source
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy [PDF]
, 2018 Dysregulated miRNA expression and mutation of genes involved in miRNA biogenesis have been reported in motor neuron diseases including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
Brecht, Johanna +44 more
core +1 more source