Results 1 to 10 of about 9,673 (191)

DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex

Frontiers in Neuroscience, 2018
DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these
Federica Marinaro, Davide De Pietri Tonelli, Tanja Vogel   +2 more
exaly   +4 more sources

From DGCR8 expression analysis to diseased pathways in 22q11.2 deletion syndrome [PDF]

Frontiers in Immunology
22q11.2 deletion syndrome (22q11.2DS) is the most prevalent microdeletion disorder, distinguished by markedly diverse clinical manifestations, with its underlying molecular mechanisms not yet fully elucidated.
Valentina Boz, Marianna Di Rosa, Alessia Pin, Eleonora De Martino, Flavio Faletra, Flavio Faletra, Francesco Baldo, Andrea Magnolato, Erica Valencic, Erica Valencic   +9 more
doaj   +5 more sources

DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair [PDF]

Scientific Reports
Ultraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions.
Takaaki Watanabe, Daiyu Yoshinami, Hiroyuki Yamasaki, Yukiko Tanaka, Masato Ohtsuka, Toshiyasu Taniguchi   +5 more
doaj   +4 more sources

Upregulation of DGCR8, a Candidate Predisposing to Schizophrenia in Han Chinese, Contributes to Phenotypic Deficits and Neuronal Migration Delay

Frontiers in Psychiatry, 2022
DiGeorge Syndrome Critical Region Gene 8 (DGCR8) is a key component of the microprocessor complex governing the maturation of most microRNAs, some of which participate in schizophrenia and neural development.
Weidong Li, Guang He, Yi Shi
exaly   +3 more sources

Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development

Frontiers in Genetics, 2020
Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic Dgcr8
Christopher Cheng, Kathy W Y Sham
exaly   +3 more sources

Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions [PDF]

JCI Insight
Germline and somatic changes in DICER1 and DGCR8 microprocessors confer risk of developing benign and malignant thyroid lesions, yet the molecular events driving malignant transformation remain unclear.
Anne-Sophie Chong, Carla Roca, Paula Morales-Sánchez, Eduard Dorca, Verónica Barea, Ignacio Ruz-Caracuel, Pablo Valderrabano, Carlota Rovira, Cristina Jou, Dorothée Bouron-Dal Soglio, Rebecca D. Chernock, Giovana T. Torrezan, Marc Pusztaszeri, José M. Cameselle-Teijeiro, Xavier Matias-Guiu, Clara V. Alvarez, Héctor Salvador, Jonathan D. Wasserman, Luis Javier Leandro-García, William D. Foulkes, Eduardo Andrés-León, Paula Casano-Sancho, Barbara Rivera   +22 more
doaj   +2 more sources

Dynamic phosphorylation of DGCR8 regulates embryonic stem cell differentiation and microprocessor function [PDF]

Frontiers in Cell and Developmental Biology
The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how
Ka Weng Leong, Ka Weng Leong, Lawrence Mok, Karen Gu, Karen Gu, Jonathan S. Oakhill, Jonathan S. Oakhill, Mark M. W. Chong, Mark M. W. Chong   +8 more
doaj   +2 more sources

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing

Cell Reports, 2017
Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA ...
Jen-Wei Huang, Bruce E Clurman, Toshiyasu Taniguchi   +2 more
exaly   +3 more sources

Risk Factors for Melanoma Survival: DGCR8 as a Predictive Factor for Mortality in Young Patients [PDF]

Acta Dermato-Venereologica
MicroRNA-processing enzymes – Dicer and DGCR8 – have been found to be dysregulated in melanoma. This study investigated whether these microRNA-processing enzymes could be used as risk factors for mortality.
Fabiola Schafer, Enrique Bellolio, Tatiana Sepúlveda, Mirta Espinoza, Juan-Jose Orellana, Miguel Angel Villaseca, Rodrigo Miranda   +6 more
doaj   +2 more sources

DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity [PDF]

European Thyroid Journal
This review examines the emerging roles of DICER1 and DGCR8, key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology.
Lia Rodrigues, Rui Sousa Martins, Valdemar Máximo, Paula Soares, Joao Vinagre, Vania Nosé, Sule Canberk   +6 more
doaj   +2 more sources