From DGCR8 expression analysis to diseased pathways in 22q11.2 deletion syndrome [PDF]
Frontiers in Immunology22q11.2 deletion syndrome (22q11.2DS) is the most prevalent microdeletion disorder, distinguished by markedly diverse clinical manifestations, with its underlying molecular mechanisms not yet fully elucidated.
Valentina Boz +9 more
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Frontiers in Psychiatry, 2022 DiGeorge Syndrome Critical Region Gene 8 (DGCR8) is a key component of the microprocessor complex governing the maturation of most microRNAs, some of which participate in schizophrenia and neural development.
Shiqing Chen, Zhenming Guo, Weibo Niu
exaly +4 more sources
DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity [PDF]
European Thyroid JournalThis review examines the emerging roles of DICER1 and DGCR8, key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology.
Lia Rodrigues +6 more
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Risk Factors for Melanoma Survival: DGCR8 as a Predictive Factor for Mortality in Young Patients [PDF]
Acta Dermato-VenereologicaMicroRNA-processing enzymes – Dicer and DGCR8 – have been found to be dysregulated in melanoma. This study investigated whether these microRNA-processing enzymes could be used as risk factors for mortality.
Fabiola Schafer +6 more
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DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair [PDF]
Scientific ReportsUltraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions.
Takaaki Watanabe +5 more
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CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway [PDF]
European Journal of Medical ResearchIntroduction Hepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments.
Zhiying Xu +6 more
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Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8. [PDF]
Nucleic Acids ResThe type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune responses.
Gázquez-Gutiérrez A +15 more
europepmc +2 more sources
Frontiers in Genetics, 2020 Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic Dgcr8
Kathy W Y Sham +2 more
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LncRNA FENDRR is involved in the progression and cisplatin resistance of non-small cell lung cancer via binding to DGCR8. [PDF]
Int J Clin Exp PatholOBJECTIVES Overcoming chemoresistance is a major therapeutic challenge to improve patient's outcome, and lncRNAs are involved in the carcinogenesis and progression of NSCLC.
Wang YJ +5 more
europepmc +2 more sources
Exosome-Mediated miRNA Delivery Restores Early Differentiation and Survival Programs in DGCR8-Deficient Mouse Embryonic Stem Cells. [PDF]
Int J Mol SciPluripotent stem cell (PSC) differentiation is orchestrated by intricate autocrine and paracrine signaling networks. Among these, exosomes, key components of the cellular secretome, are implicated as crucial mediators of intercellular communication via ...
Ha TW +10 more
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