Results 1 to 10 of about 8,581 (127)
Frontiers in Genetics, 2020 Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic Dgcr8
Christopher H K Cheng +2 more
exaly +3 more sources
DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing
Cell Reports, 2017 Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA ...
, Bruce Clurman, Toshiyasu Taniguchi
exaly +3 more sources
Frontiers in Psychiatry, 2022 DiGeorge Syndrome Critical Region Gene 8 (DGCR8) is a key component of the microprocessor complex governing the maturation of most microRNAs, some of which participate in schizophrenia and neural development.
Yan Bi +40 more
doaj +1 more source
Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. [PDF]
PLoS ONE, 2012 Human DiGeorge Critical Region 8 (DGCR8) is an essential microRNA (miRNA) processing factor that is activated via direct interaction with Fe(III) heme. In order for DGCR8 to bind heme, it must dimerize using a dimerization domain embedded within its heme-
Rachel Senturia +5 more
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Establishing a human embryonic stem cell clone with a heterozygous mutation in the DGCR8 gene
Stem Cell Research, 2021 DiGeorge Syndrome (DGS) Critical Region 8 (DGCR8) is a primary candidate gene in they DGS. The DGCR8 microprocessor complex subunit is an essential cofactor in the canonical miRNA biogenesis which is involved in diverse cellular functions such as cell ...
Dóra Reé +9 more
doaj +1 more source
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria
Life Science Alliance, 2021 Lack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.
Barbara Killy +9 more
doaj +1 more source
The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response
Frontiers in Immunology, 2022 We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T cell-
Patrick Daum +10 more
doaj +1 more source
Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile
Cell Reports, 2013 During miRNA biogenesis, the microprocessor complex (MC), which is composed minimally of Drosha, an RNase III enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary miRNA (pri-miRNA) in order to release the pre-miRNA stem-loop ...
Kristina M. Herbert +4 more
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Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Pre-eclampsia is a serious problem of pregnancy that is associated with proteinuria and increased blood pressure in the second half of pregnancy. It is one of the three leading causes of maternal and fetal mortality. Dysregulated expression
Roghayeh Dargahi +3 more
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Frontiers in Neuroscience, 2018 DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these
Nadin Hoffmann +4 more
doaj +1 more source