Results 21 to 30 of about 9,673 (191)
Primary MicroRNA Processing Assay Reconstituted Using Recombinant Drosha and DGCR8 [PDF]
, 2013 In animals, the Microprocessor complex cleaves primary transcripts of microRNAs (pri-miRNAs) to produce precursor microRNAs in the nucleus. The core components of Microprocessor include the Drosha ribonuclease and its RNA-binding partner protein DiGeorge
Ian Barr +5 more
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The role of DGCR8 in mammalian pluripotency and innate immunity [PDF]
, 2022 DGCR8 is an RNA-binding protein involved in canonical micro (mi)RNA biogenesis as part of the nuclear microprocessor complex. While absence of DGCR8 in mammals is lethal, DGCR8 hemizygosity is observed in 22q11.2 deletion syndrome (22q11.2DS), the ...
Knol, Lisanne Iris
core +3 more sources
Scientific Reports, 2018 DiGeorge syndrome chromosomal region 8 (DGCR8), a double-stranded-RNA-binding protein, participates in the miRNA biogenesis pathway and contributes to miRNA maturation by interacting with the RNAase III enzyme Drosha in cell nuclei.
Yanan Zou +9 more
doaj +2 more sources
Disrupted miRNA Biogenesis Machinery Reveals Common Molecular Pathways and Diagnostic Potential in MDS and AML [PDF]
BiomedicinesBackground: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal stem cell disorders in which disrupted post-transcriptional regulation contributes to aberrant hematopoiesis and leukemic transformation.
Kenan Çevik +5 more
doaj +2 more sources
Regulation of the microprocessor by post-translational modifications [PDF]
Frontiers in Cell and Developmental BiologyThe Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong +3 more
doaj +2 more sources
The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin [PDF]
Cell Reports, 2014 Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-
Jen Quick-Cleveland +5 more
doaj +2 more sources
The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesThe microRNAs have been implicated in the development and function of the inner ear, especially in contribution to hearing. However, the impact of idiopathic sudden sensorineural hearing loss (SSNHL) on expression of miRNA biogenesis-related ...
Soon Yong Han +4 more
doaj +4 more sources
International Journal of General Medicine, 2020 Emad Babakhanzadeh,1,2,* Ali Khodadadian,1,* Majid Nazari,1 Masoud Dehghan Tezerjani,1 Seyed Mohsen Aghaei,1 Sina Ghasemifar,1 Mehdi Hosseinnia,3 Mahta Mazaheri1,4 1Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd ...
Ali Khodadadian +2 more
exaly +2 more sources
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex [PDF]
Cell, 2006 SummaryThe Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary transcripts (pri-miRNAs).
Han, JJ +21 more
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ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8 [PDF]
Nucleic Acids Research, 2020 The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and dsRNA-binding DGCR8.
Wang, Suman +35 more
core +4 more sources