Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile
Cell Reports, 2013 During miRNA biogenesis, the microprocessor complex (MC), which is composed minimally of Drosha, an RNase III enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary miRNA (pri-miRNA) in order to release the pre-miRNA stem-loop ...
Kristina M. Herbert +4 more
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Noncanonical function of DGCR8 controls mESC exit from pluripotency [PDF]
Journal of Cell Biology, 2017 Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive.
Yu, Jian +16 more
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Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. [PDF]
PLoS ONE, 2012 Human DiGeorge Critical Region 8 (DGCR8) is an essential microRNA (miRNA) processing factor that is activated via direct interaction with Fe(III) heme. In order for DGCR8 to bind heme, it must dimerize using a dimerization domain embedded within its heme-
Rachel Senturia +5 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background RNA binding proteins (RBPs)—regulated gene expression play a vital role in various pathological processes, including the progression of cancer. However, the role of RBP in hepatocellular carcinoma (HCC) remains much unknown.
Shuang Tao +8 more
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DGCR8-dependent microRNA biogenesis is essential for skin development [PDF]
Proceedings of the National Academy of Sciences, 2009 MicroRNAs play important roles in animal development. Numerous conditional knockout (cKO) studies of Dicer have been performed to interrogate the functions of microRNA during mammalian development.
Sander, C. +10 more
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Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA
Molecular Cell, 2020 Summary Metazoan microRNAs require specific maturation steps initiated by Microprocessor, comprised of Drosha and DGCR8. Lack of structural information for the assembled complex has hindered understanding how Microprocessor recognizes primary microRNA ...
Kaiming Zhang +2 more
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The role of DGCR8 in mammalian pluripotency and innate immunity [PDF]
, 2022 DGCR8 is an RNA-binding protein involved in canonical micro (mi)RNA biogenesis as part of the nuclear microprocessor complex. While absence of DGCR8 in mammals is lethal, DGCR8 hemizygosity is observed in 22q11.2 deletion syndrome (22q11.2DS), the ...
Knol, Lisanne Iris
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DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis [PDF]
Journal of Clinical Investigation, 2020 Data source: Supplementary materials, https://pmc.ncbi.nlm.nih.gov/articles/instance/7269565/bin/jci-130-130206-s223.pdfBACKGROUND. DICER1 is the only miRNA biogenesis component associated with an inherited tumor syndrome, featuring multinodular goiter ...
Apellaniz Ruiz, M. +5 more
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A non-canonical role for HIF-1α: redirecting DGCR8 to the RNA exosome for snoRNA degradation and translational modulation. [PDF]
Nucleic Acids ResThe RNA exosome complex (EC) is a multi-protein complex responsible for RNA surveillance. Guided by specific adaptor factors, the EC recognizes RNA species as substrates for processing or degradation.
Li JN +6 more
europepmc +2 more sources
Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma
CellsMicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for ...
Lia Rodrigues +3 more
semanticscholar +5 more sources