Results 11 to 20 of about 8,581 (127)

Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions [PDF]

JCI Insight
Germline and somatic changes in DICER1 and DGCR8 microprocessors confer risk of developing benign and malignant thyroid lesions, yet the molecular events driving malignant transformation remain unclear.
Anne-Sophie Chong, Carla Roca, Paula Morales-Sánchez, Eduard Dorca, Verónica Barea, Ignacio Ruz-Caracuel, Pablo Valderrabano, Carlota Rovira, Cristina Jou, Dorothée Bouron-Dal Soglio, Rebecca D. Chernock, Giovana T. Torrezan, Marc Pusztaszeri, José M. Cameselle-Teijeiro, Xavier Matias-Guiu, Clara V. Alvarez, Héctor Salvador, Jonathan D. Wasserman, Luis Javier Leandro-García, William D. Foulkes, Eduardo Andrés-León, Paula Casano-Sancho, Barbara Rivera   +22 more
doaj   +2 more sources

From DGCR8 expression analysis to diseased pathways in 22q11.2 deletion syndrome [PDF]

Frontiers in Immunology
22q11.2 deletion syndrome (22q11.2DS) is the most prevalent microdeletion disorder, distinguished by markedly diverse clinical manifestations, with its underlying molecular mechanisms not yet fully elucidated.
Valentina Boz, Marianna Di Rosa, Alessia Pin, Eleonora De Martino, Flavio Faletra, Flavio Faletra, Francesco Baldo, Andrea Magnolato, Erica Valencic, Erica Valencic   +9 more
doaj   +2 more sources

Risk Factors for Melanoma Survival: DGCR8 as a Predictive Factor for Mortality in Young Patients [PDF]

Acta Dermato-Venereologica
MicroRNA-processing enzymes – Dicer and DGCR8 – have been found to be dysregulated in melanoma. This study investigated whether these microRNA-processing enzymes could be used as risk factors for mortality.
Fabiola Schafer, Enrique Bellolio, Tatiana Sepúlveda, Mirta Espinoza, Juan-Jose Orellana, Miguel Angel Villaseca, Rodrigo Miranda   +6 more
doaj   +2 more sources

DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity [PDF]

European Thyroid Journal
This review examines the emerging roles of DICER1 and DGCR8, key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology.
Lia Rodrigues, Rui Sousa Martins, Valdemar Máximo, Paula Soares, Joao Vinagre, Vania Nosé, Sule Canberk   +6 more
doaj   +2 more sources

DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair [PDF]

Scientific Reports
Ultraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions.
Takaaki Watanabe, Daiyu Yoshinami, Hiroyuki Yamasaki, Yukiko Tanaka, Masato Ohtsuka, Toshiyasu Taniguchi   +5 more
doaj   +2 more sources

Disrupted miRNA Biogenesis Machinery Reveals Common Molecular Pathways and Diagnostic Potential in MDS and AML [PDF]

Biomedicines
Background: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal stem cell disorders in which disrupted post-transcriptional regulation contributes to aberrant hematopoiesis and leukemic transformation.
Kenan Çevik, Mustafa Ertan Ay, Anıl Tombak, Özlem İzci Ay, Ümit Karakaş, Mehmet Emin Erdal   +5 more
doaj   +2 more sources

Regulation of the microprocessor by post-translational modifications [PDF]

Frontiers in Cell and Developmental Biology
The Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong, Ka Weng Leong, Mark M. W. Chong, Mark M. W. Chong   +3 more
doaj   +2 more sources

CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway [PDF]

European Journal of Medical Research
Introduction Hepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments.
Zhiying Xu, Wei Shi, Jialun Ren, Qifei Zou, Mingming Fan, Yiran Li, Dong Jiang   +6 more
doaj   +2 more sources

DGCR8/miR-106 Axis Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinomas by Downregulating RUNX3

Frontiers in Medicine, 2020
Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignant tumor worldwide, and the radiotherapy effect is strongly associated with human papillomavirus (HPV) infection. Therefore, the aim of our study was to analyze the
Chunlin Zhang, Hangqi Chen, Zeyi Deng, Dan Long, Li Xu, Zhaohui Liu   +5 more
doaj   +1 more source

Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.

PLoS ONE, 2009
BackgroundThe Microprocessor, containing the RNA binding protein Dgcr8 and RNase III enzyme Drosha, is responsible for processing primary microRNAs to precursor microRNAs.
Archana Shenoy, Robert Blelloch
doaj   +1 more source