Results 11 to 20 of about 10,226 (209)
DGCR8 Microprocessor Subunit Mutation and Expression Deregulation in Thyroid Lesions
International Journal of Molecular Sciences, 2022 DGCR8 emerged recently as miRNAs biogenesis pathway protein with a highlighted role in thyroid disease. This study aimed to characterize this miRNA biogenesis component, in particular the p.(E518K) mutation and DGCR8 expression in a series of thyroid ...
Lia Rodrigues +2 more
exaly +6 more sources
Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis [PDF]
Nature Communications, 2019 DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 ...
Liping Deng +14 more
doaj +4 more sources
The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response [PDF]
Frontiers in Immunology, 2022 We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T cell-
Patrick Daum +10 more
doaj +3 more sources
Frontiers in Neuroscience, 2018 DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these
Federica Marinaro +2 more
exaly +4 more sources
The Drosha-DGCR8 complex in primary microRNA processing. [PDF]
Genes & Development, 2004 RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to generate mature miRNAs.
Jinju Han +5 more
semanticscholar +4 more sources
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects. [PDF]
Nucleic Acids ResThe 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 22qDS is caused by a microdeletion in one chromosome 22, including DGCR8, an essential gene for microRNA ...
Colomer-Boronat A +15 more
europepmc +5 more sources
DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing [PDF]
Cell Reports, 2017 Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA ...
Yong Chi +2 more
exaly +4 more sources
Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs [PDF]
Nature Communications, 2017 Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular ...
Alexander C. Partin +5 more
doaj +4 more sources
Crystal structure of human DGCR8 core
Nature Structural & Molecular Biology, 2018 A complex of Drosha with DGCR8 ( or its homolog Pasha) cleaves primary microRNA ( pri- miRNA) substrates into precursor miRNA and initiates the microRNA maturation process.
Sohn, SY +5 more
core +5 more sources
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor [PDF]
Nature Structural & Molecular Biology, 2012 The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking immunoprecipitation (HITS-CLIP) we
Cáceres, Javier F. +14 more
core +7 more sources