Results 11 to 20 of about 9,673 (191)
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor [PDF]
Nature Structural & Molecular Biology, 2012 The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking immunoprecipitation (HITS-CLIP) we
Cáceres, Javier F. +14 more
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Crystal structure of human DGCR8 core
Nature Structural & Molecular Biology, 2018 A complex of Drosha with DGCR8 ( or its homolog Pasha) cleaves primary microRNA ( pri- miRNA) substrates into precursor miRNA and initiates the microRNA maturation process.
Sohn, SY +5 more
core +5 more sources
Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile
Cell Reports, 2013 During miRNA biogenesis, the microprocessor complex (MC), which is composed minimally of Drosha, an RNase III enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary miRNA (pri-miRNA) in order to release the pre-miRNA stem-loop ...
Kristina M. Herbert +4 more
doaj +2 more sources
Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. [PDF]
PLoS ONE, 2012 Human DiGeorge Critical Region 8 (DGCR8) is an essential microRNA (miRNA) processing factor that is activated via direct interaction with Fe(III) heme. In order for DGCR8 to bind heme, it must dimerize using a dimerization domain embedded within its heme-
Rachel Senturia +5 more
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Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis [PDF]
Nature Communications, 2019 DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 ...
Liping Deng +14 more
doaj +3 more sources
DGCR8-dependent microRNA biogenesis is essential for skin development [PDF]
Proceedings of the National Academy of Sciences, 2009 MicroRNAs play important roles in animal development. Numerous conditional knockout (cKO) studies of Dicer have been performed to interrogate the functions of microRNA during mammalian development.
Sander, C. +10 more
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The Drosha-DGCR8 complex in primary microRNA processing [PDF]
Genes & Development, 2004 RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to generate mature miRNAs.
Yeom, Kyu-Hyun +17 more
core +3 more sources
DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis [PDF]
Journal of Clinical Investigation, 2020 Data source: Supplementary materials, https://pmc.ncbi.nlm.nih.gov/articles/instance/7269565/bin/jci-130-130206-s223.pdfBACKGROUND. DICER1 is the only miRNA biogenesis component associated with an inherited tumor syndrome, featuring multinodular goiter ...
Apellaniz Ruiz, M. +5 more
core +4 more sources
Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia [PDF]
BMC Medical Genetics, 2019 Background PE (preeclampsia) is a heterogeneous disorder with early onset PE (EOPE) and late onset PE (LOPE) subtypes. Associations between maternal miRNAs biosynthesis genes polymorphisms and risk of PE have been previously observed. However, the impact
Xin Huang +4 more
doaj +3 more sources
The UGU-recognizing mechanism of DGCR8
, 2019 Human Microprocessor is a trimeric complex, composed of a RNase Ill - Drosha and the DGCR8 (DiGeorge syndrome chromosomal region 8) dimer, that processes primary microRNAs (pri-miRNAs) to initiate microRNA (miRNA) biogenesis.
Dang, Thi Lieu
core +3 more sources