Regulation of the microprocessor by post-translational modifications [PDF]
Frontiers in Cell and Developmental BiologyThe Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong +3 more
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International Journal of General Medicine, 2020 Emad Babakhanzadeh,1,2,* Ali Khodadadian,1,* Majid Nazari,1 Masoud Dehghan Tezerjani,1 Seyed Mohsen Aghaei,1 Sina Ghasemifar,1 Mehdi Hosseinnia,3 Mahta Mazaheri1,4 1Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd ...
Babakhanzadeh E +7 more
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Life, 2021 The chromosome 22q11.21 copy number variant (CNV) is a vital risk factor that can be a genetic predisposition to neurodevelopmental disorders (NDD). As the 22q11.21 CNV affects multiple genes, causal disease genes and mechanisms affected are still poorly
Liang Chen +4 more
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The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesThe microRNAs have been implicated in the development and function of the inner ear, especially in contribution to hearing. However, the impact of idiopathic sudden sensorineural hearing loss (SSNHL) on expression of miRNA biogenesis-related ...
Soon Yong Han +4 more
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Noncanonical functions of microRNA pathway enzymes – Drosha, DGCR8, Dicer and Ago proteins
FEBS Letters, 2018 MicroRNAs (miRNAs) are small regulatory noncoding RNAs that are generated in the canonical RNA interference (RNAi) pathway. Drosha, DiGeorge syndrome critical region 8 (DGCR8) and Dicer are key players in miRNA biogenesis.
Sheng Kai Pong, Monika Gullerova
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ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8 [PDF]
Nucleic Acids Research, 2020 The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and dsRNA-binding DGCR8.
S. -. Kwon +11 more
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Correction: RNA‑binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non‑canonical role of DGCR8 in mRNA localization. [PDF]
J Exp Clin Cancer ResTao S +8 more
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DGCR8-dependent control of antiviral immunity in human cells [PDF]
The type I interferon (IFN) pathway is tightly regulated to prevent undesired consequences, such as inflammation and autoimmunity. Several regulatory mechanisms control the optimal levels of type I IFNs and proinflammatory cytokines.
Chin, Priscilla Sze-Ya
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Establishing a human embryonic stem cell clone with a heterozygous mutation in the DGCR8 gene
Stem Cell Research, 2021 DiGeorge Syndrome (DGS) Critical Region 8 (DGCR8) is a primary candidate gene in they DGS. The DGCR8 microprocessor complex subunit is an essential cofactor in the canonical miRNA biogenesis which is involved in diverse cellular functions such as cell ...
Dóra Reé +9 more
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DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria
Life Science Alliance, 2021 Lack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.
Barbara Killy +9 more
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