Results 41 to 50 of about 9,673 (191)
Frontiers in Medicine, 2020 Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignant tumor worldwide, and the radiotherapy effect is strongly associated with human papillomavirus (HPV) infection. Therefore, the aim of our study was to analyze the
Chunlin Zhang +5 more
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Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8 [PDF]
, 2022 MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis.
Partin, Alexander Christian
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PLoS ONE, 2009 BackgroundThe Microprocessor, containing the RNA binding protein Dgcr8 and RNase III enzyme Drosha, is responsible for processing primary microRNAs to precursor microRNAs.
Archana Shenoy, Robert Blelloch
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Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase. Most scaRNAs, the RNA component of scaRNPs, accumulate in CBs.
Douglas M. McLaurin +3 more
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Stem Cell Reports, 2017 Summary: Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8−/− or Dicer−/– embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells.
Zhong Liu +12 more
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WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex
Life Science Alliance, 2021 WBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.
Hossein Tabatabaeian +4 more
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Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures [PDF]
Biophysical Journal, 2020 Although conformational dynamics of RNA molecules are potentially important in microRNA (miRNA) processing, the role of the protein binding partners in facilitating the requisite structural changes is not well understood. In previous work, we and others have demonstrated that nonduplex structural elements and the conformational flexibility they support
Suzette A. Pabit +5 more
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Redox Biology, 2020 The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic ...
Yi-deun Jung +14 more
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Noncanonical function of DGCR8 controls mESC exit from pluripotency [PDF]
Journal of Cell Biology, 2017 Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the exit from the pluripotency state.
Daniel Cirera-Salinas +5 more
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, 2014 a) box plots showing a decreased DGCR8 mRNA levels in subjects with 22q11DS compared to TD and b) DGCR8 protein expression levels measured by Western blot analysis shows a significant decrease in 22q11DS individuals when compared to TD controls.
Blythe Durbin-Johnson (185037) +9 more
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