Results 51 to 60 of about 10,226 (209)
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. [PDF]
Cell, 2006 The Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary transcripts (pri-miRNAs). Here we propose a model for this process that is based upon evidence from both computational and biochemical analyses. A typical metazoan pri-miRNA consists of a stem of approximately 33 bp, with a terminal
Jinju Han +9 more
semanticscholar +4 more sources
PeerJ, 2023 Oral squamous cell carcinoma (OSCC) is the 11th most prevalent tumor worldwide. Despite advantages of therapeutic approaches, the 5-year survival rate of patients with OSCC is less than 50%.
Xiaoxu Li +5 more
semanticscholar +1 more source
Post-transcriptional control of DGCR8 expression by the Microprocessor [PDF]
RNA, 2009 The Microprocessor, comprising the RNase III Drosha and the double-stranded RNA binding protein DGCR8, is essential for microRNA (miRNA) biogenesis. In the miRNA processing pathway certain hairpin structures within primary miRNA (pri-miRNA) transcripts are specifically cleaved by the Microprocessor to release ∼60–70-nucleotide precursor miRNA (pre ...
Robinson, Triboulet +3 more
openaire +2 more sources
Versatility of DGCR8 controls stem cell fate [PDF]
Cell Cycle, 2017 MicroRNAs (miRNA) are a class of small non-coding RNAs, which control the expression of protein coding genes via translational repression and/or mRNA degradation.
D. Cirera-Salinas, M. Bodak, C. Ciaudo
openaire +3 more sources
Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1 [PDF]
Cancer Research, 2010 Abstract The ING family of tumor suppressor proteins controls several cellular functions relevant to antitumor protection, such as cell cycle control, apoptosis, senescence, or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognition of histone marks and ...
Gómez-Cabello, Daniel +5 more
openaire +3 more sources
Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Pre-eclampsia is a serious problem of pregnancy that is associated with proteinuria and increased blood pressure in the second half of pregnancy. It is one of the three leading causes of maternal and fetal mortality. Dysregulated expression
Roghayeh Dargahi +3 more
doaj +1 more source
Frontiers in Medicine, 2020 Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignant tumor worldwide, and the radiotherapy effect is strongly associated with human papillomavirus (HPV) infection. Therefore, the aim of our study was to analyze the
Chunlin Zhang +5 more
doaj +1 more source
Cancer Research Communications, 2023 miRNA biogenesis is a cellular process that produces mature miRNAs from their primary transcripts, pri-miRNAs, via two RNAse III enzyme complexes: the Drosha-DGCR8 microprocessor complex in the nucleus and the Dicer-TRBP complex in the cytoplasm ...
Yanping Li +5 more
semanticscholar +1 more source
PLoS ONE, 2009 BackgroundThe Microprocessor, containing the RNA binding protein Dgcr8 and RNase III enzyme Drosha, is responsible for processing primary microRNAs to precursor microRNAs.
Archana Shenoy, Robert Blelloch
doaj +1 more source
Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase. Most scaRNAs, the RNA component of scaRNPs, accumulate in CBs.
Douglas M. McLaurin +3 more
openaire +3 more sources