Results 51 to 60 of about 9,673 (191)

DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions [PDF]

, 2023
Deregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of
Rodrigues, Lia, Vinagre, João, Canberk, Sule, Macedo, Sofia, Soares, Paula   +4 more
core   +2 more sources

Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

Neural Development, 2011
Background Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism.
Barker Alison J, Hsu Ruby, Schofield Claude M, Gertz Caitlyn C, Blelloch Robert, Ullian Erik M   +5 more
doaj   +1 more source

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing

, 2006
DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes.
Suh, Mi Ra, Kim, V. Narry, Han, Jinju, Yeom, Kyu-Hyeon, Lee, Yoontae   +4 more
core   +1 more source

Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming

Stem Cell Reports, 2015
MicroRNAs (miRNAs) are important regulators of reprogramming of somatic cells into induced pluripotent stem cells (iPSCs); however, it is unclear whether miRNAs are required for reprogramming and whether miRNA activity as a whole facilitates ...
Zhong Liu, Maria Skamagki, Kitai Kim, Rui Zhao   +3 more
doaj   +1 more source

Analysis of heme iron coordination in DGCR8: The heme-binding component of the microprocessor complex [PDF]

, 2016
DGCR8 is the RNA-binding partner of the nuclease Drosha. Their complex (the “Microprocessor”) is essential for processing of long, primary microRNAs (pri-miRNAs) in the nucleus. Binding of heme to DGCR8 is essential for pri-miRNA processing. On the basis
Yilin Liu (1991839), Myles R. Cheesman (1353777), Fisher, Karl, David Leys (1328622), Justin M. Bradley (2137579), Karl Fisher (1740823), Rigby, Stephen E. J., Bradley, Justin M., Kincaid, James R., James R. Kincaid (1313820), Kazimierz Czarnecki (1928854), Cheesman, Myles R., Liu, Yilin, Czarnecki, Kazimierz, Stephen E. J. Rigby (110349), Leys, David, Munro, Andrew W., Hazel M. Girvan (3093705), Andrew W. Munro (237207), Girvan, Hazel M.   +19 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Spatiotemporal 22q11.21 Protein Network Implicates DGCR8-Dependent MicroRNA Biogenesis as a Risk for Late Fetal Cortical Development in Psychiatric Diseases

Life, 2021
The chromosome 22q11.21 copy number variant (CNV) is a vital risk factor that can be a genetic predisposition to neurodevelopmental disorders (NDD). As the 22q11.21 CNV affects multiple genes, causal disease genes and mechanisms affected are still poorly
Liang Chen, Wenxiang Cai, Weidi Wang, Zhe Liu, Guan-Ning Lin   +4 more
doaj   +1 more source

Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice [PDF]

, 2017
DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm.
김형범
core   +1 more source

A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183–182 Families in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Summary: Dgcr8 knockout cells provide a great means to understand the function of microRNAs (miRNAs) in vitro and in vivo. Current strategies to study miRNA function in Dgcr8 knockout cells depend on transient transfection of chemically synthesized miRNA
Xi-Wen Wang, Jing Hao, Wen-Ting Guo, Le-Qi Liao, Si-Yue Huang, Xiangpeng Guo, Xichen Bao, Miguel A. Esteban, Yangming Wang   +8 more
doaj   +1 more source

MGP_HNSC32: A H&E Morphology‐Derived 32‐Gene Prognostic Signature in Head and Neck Squamous Cell Carcinoma

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits substantial molecular and morphological heterogeneity, yet current morphology‐based prognostic models often lack biological interpretability. We developed a transformer‐based computational framework (CTransPath) to virtually predict gene expression directly from hematoxylin and eosin (H&E ...
Di Zhao, Zhiheng Huang, Jing Xu, Zheng Zhang, Jochen Hess, Bohai Feng   +5 more
wiley   +1 more source